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Open AccessArticle
Diabetes Mellitus and Gynecological and Inflammation Disorders Increased the Risk of Pregnancy Loss in a Population Study
by
Chun-Gu Cheng
Chun-Gu Cheng 1,2,†,
Sheng-Hua Su
Sheng-Hua Su 3,†,
Wu-Chien Chien
Wu-Chien Chien 4,5,
Ryan Chen
Ryan Chen 6,
Chi-Hsiang Chung
Chi-Hsiang Chung 4,5 and
Chun-An Cheng
Chun-An Cheng 7,*
1
Department of Emergency Medicine, Taoyuan Armed Forces General Hospital, Taoyuan 32549, Taiwan
2
Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
3
Department of Pulmonary Medicine, Cheng-Hsin General Hospital, Taipei 11220, Taiwan
4
School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan
5
Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
6
Upper School, Taipei American School, Taipei 111039, Taiwan
7
Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Life 2024, 14(7), 903; https://doi.org/10.3390/life14070903 (registering DOI)
Submission received: 16 June 2024
/
Revised: 11 July 2024
/
Accepted: 18 July 2024
/
Published: 19 July 2024
Abstract
(1) Background: Diabetes mellitus (DM) induces oxidative stress and inflammation with negative effect on pregnancy outcomes. This study aimed to determine whether DM increases the risk of pregnancy loss and to identify other potential risk factors; (2) Methods: We identified female patients diagnosed with DM from 2000–2015 in the Taiwanese National Health Insurance Research Database according to the International Classification of Diseases, Ninth Edition, Clinical Modification (ICD-9 CM) code 250. The event was pregnancy loss, defined as ICD-9 CM codes 630–639, which was tracked until 31 December 2015. The control group included 4-fold more non-DM female patients who were matched for age and disease severity. Multivariate Cox regression was employed to determine the risk factors associated with pregnancy loss; (3) Results: The hazard ratio (HR) for the risk of pregnancy loss due to DM was 1.407 (95% confidence interval: 1.099–1.801, p = 0.007), and the risk factors for older age, gynecological disorders and inflammation disorders were included. (4) Conclusions: The study concluded that women with DM have a greater risk of experiencing pregnancy loss. Healthcare providers should proactively manage and educate diabetic patients to reduce their risk of pregnancy loss. Understanding other probable risk factors can help in developing targeted interventions and support systems for women to improve pregnancy outcomes.
Share and Cite
MDPI and ACS Style
Cheng, C.-G.; Su, S.-H.; Chien, W.-C.; Chen, R.; Chung, C.-H.; Cheng, C.-A.
Diabetes Mellitus and Gynecological and Inflammation Disorders Increased the Risk of Pregnancy Loss in a Population Study. Life 2024, 14, 903.
https://doi.org/10.3390/life14070903
AMA Style
Cheng C-G, Su S-H, Chien W-C, Chen R, Chung C-H, Cheng C-A.
Diabetes Mellitus and Gynecological and Inflammation Disorders Increased the Risk of Pregnancy Loss in a Population Study. Life. 2024; 14(7):903.
https://doi.org/10.3390/life14070903
Chicago/Turabian Style
Cheng, Chun-Gu, Sheng-Hua Su, Wu-Chien Chien, Ryan Chen, Chi-Hsiang Chung, and Chun-An Cheng.
2024. "Diabetes Mellitus and Gynecological and Inflammation Disorders Increased the Risk of Pregnancy Loss in a Population Study" Life 14, no. 7: 903.
https://doi.org/10.3390/life14070903
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