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Open AccessArticle
Evaluation of Biocomposite Cements for Bone Defect Repair in Rat Models
by
Alina Ioana Ardelean
Alina Ioana Ardelean 1
,
Sorin Marian Mârza
Sorin Marian Mârza 2,*,
Raluca Marica
Raluca Marica 3,*
,
Mădălina Florina Dragomir
Mădălina Florina Dragomir 1
,
Alina Oana Rusu-Moldovan
Alina Oana Rusu-Moldovan 4,
Mărioara Moldovan
Mărioara Moldovan 5
,
Paula Maria Pașca
Paula Maria Pașca 6 and
Liviu Oana
Liviu Oana 1
1
Department of Veterinary Surgery, Faculty of Veterinary Medicine, University of Agricultura Sciencies and Veterinary Medicine, 3–5 Manastur Street, 400372 Cluj-Napoca, Romania
2
Department of Veterinary Imagistics, Faculty of Veterinary Medicine, University of Agricultura Sciencies and Veterinary Medicine, 3–5 Manastur Street, 400372 Cluj-Napoca, Romania
3
Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Agricultura Sciencies and Veterinary Medicine, 3–5 Manastur Street, 400372 Cluj-Napoca, Romania
4
Department of Surgery III, Institute of Oncology “Prof. Dr. Alexandru Trestioreanu”, 022328 Bucharest, Romania
5
Raluca Ripan Institute for Research in Chemistry, Babeș-Bolyai University, 30 Fantanele Street, 400294 Cluj-Napoca, Romania
6
Clinics Department, Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 700489 Iasi, Romania
*
Authors to whom correspondence should be addressed.
Life 2024, 14(9), 1097; https://doi.org/10.3390/life14091097 (registering DOI)
Submission received: 1 August 2024
/
Revised: 24 August 2024
/
Accepted: 28 August 2024
/
Published: 30 August 2024
Abstract
Repairing or reconstructing significant bone defects is typically challenging. In the present study, two composite cements were used as scaffolds in a sub-critical femoral defect in rats. A control group and two experimental batches were used to compare the outcomes. This research aimed to investigate the osteogenic potential and toxicological tolerance of the bioproducts through histopathology and computed tomography imaging analysis at 14, 28, 56, and 90 days post-implantation. The biomaterials used in the investigation consisted of a 65% bioactive salinized inorganic filler and a 25% weight organic matrix. The organic part of the biomaterial was composed of Bis-GMA (bisphenol A-glycidyl methacrylate), UDMA (urethane dimethacrylate), HEMA (2-Hydroxyethyl methacrylate), and TEGDMA (triethylene glycol dimethacrylate), while the inorganic filler was composed of silica, barium glass, hydroxyapatite, and fluor aluminosilicate glass. The first findings of this research are encouraging, revealing that there is a slight difference between the groups treated with biomaterials, but it might be an effective approach for managing bone abnormalities. Material C1 exhibited a faster bone defect healing time compared to material C2, where bone fractures occurred in some individuals. It is unclear if the fractures were caused by the presence of the biomaterial C2 or whether additional variables were to blame. By the end of the research, the mice appeared to tolerate the biomaterials without exhibiting any inflammatory or rejection responses.
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MDPI and ACS Style
Ardelean, A.I.; Mârza, S.M.; Marica, R.; Dragomir, M.F.; Rusu-Moldovan, A.O.; Moldovan, M.; Pașca, P.M.; Oana, L.
Evaluation of Biocomposite Cements for Bone Defect Repair in Rat Models. Life 2024, 14, 1097.
https://doi.org/10.3390/life14091097
AMA Style
Ardelean AI, Mârza SM, Marica R, Dragomir MF, Rusu-Moldovan AO, Moldovan M, Pașca PM, Oana L.
Evaluation of Biocomposite Cements for Bone Defect Repair in Rat Models. Life. 2024; 14(9):1097.
https://doi.org/10.3390/life14091097
Chicago/Turabian Style
Ardelean, Alina Ioana, Sorin Marian Mârza, Raluca Marica, Mădălina Florina Dragomir, Alina Oana Rusu-Moldovan, Mărioara Moldovan, Paula Maria Pașca, and Liviu Oana.
2024. "Evaluation of Biocomposite Cements for Bone Defect Repair in Rat Models" Life 14, no. 9: 1097.
https://doi.org/10.3390/life14091097
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