Mediastinal Metastasis Isolated in Ovarian Cancer: A Systematic Review
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Sources
2.2. Study Selection Criteria
2.3. Selected Studies
2.4. Literature Review
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Thomakos, N.; Diakosavvas, M.; Machairiotis, N.; Fasoulakis, Z.; Zarogoulidis, P.; Rodolakis, A. Rare Distant Metastatic Disease of Ovarian and Peritoneal Carcinomatosis: A Review of the Literature. Cancers 2019, 11, 1044. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Hamaji, M.; Yamaguchi, K.; Koyasu, S.; Date, H. Thoracoscopic Resection of Fluorodeoxyglucose-Avid Mediastinal Lymph Nodes Associated with Advanced Ovarian Carcinoma. Thorac. Cardiovasc. Surg. 2019, 67, 692–696. [Google Scholar] [CrossRef] [PubMed]
- Scarci, M.; Attia, R.; Routledge, T.; King, J. A rare case of high-grade serous ovarian epithelial carcinoma presenting as an isolated cystic mediastinal mass: A case report and brief review of the literature. Ann. R. Coll. Surg. Engl. 2010, 92, W57–W58. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Dueño, S.; Stein, R.; Jamal, M.; Lewis, G.; Hew, K. Metastasis of serous ovarian carcinoma to the breast: A case report and review of the literature. J. Med. Case Rep. 2024, 18, 127. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Georgescu, M.T.; Georgescu, D.E.; Georgescu, T.F.; Serbanescu, L.G. Changing the Prognosis of Metastatic Cervix Uteri Adenosquamous Carcinoma through a Multimodal Approach: A Case Report. Case Rep. Oncol. 2020, 13, 1545–1551. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Chan, J.K.; Chow, S.; Bhowmik, S.; Mann, A.; Kapp, D.S.; Coleman, R.L. Metastatic gynecologic malignancies: Advances in treatment and management. Clin. Exp. Metastasis 2018, 35, 521–533. [Google Scholar] [CrossRef] [PubMed]
- Dhillon, S.S.; Harris, K.; Pokharel, S.; Yendamuri, S. Calcified Mediastinal Metastasis of Ovarian Cancer Mimicking Broncholithiasis. J. Bronchol. Interv. Pulmonol. 2016, 23, 229–231. [Google Scholar] [CrossRef] [PubMed]
- Blanchard, P.; Plantade, A.; Pagès, C.; Afchain, P.; Louvet, C.; Tournigand, C.; de Gramont, A. Isolated lymph node relapse of epithelial ovarian carcinoma: Outcomes and prognostic factors. Gynecol. Oncol. 2007, 104, 41–45. [Google Scholar] [CrossRef] [PubMed]
- Oguchi, M.; Higashi, K.; Taniguchi, M.; Tamamura, H.; Okimura, T.; Yamamoto, I. Calcified mediastinal metastases from ovarian cancer imaged with Tc-99m MDP SPECT. Clin. Nucl. Med. 1998, 23, 479–481. [Google Scholar] [CrossRef] [PubMed]
- Moran, C.A.; Suster, S.; Silva, E.G. Low-grade serous carcinoma of the ovary metastatic to the anterior mediastinum simulating multilocular thymic cysts: A clinicopathologic and immunohistochemical study of 3 cases. Am. J. Surg. Pathol. 2005, 29, 496–499. [Google Scholar] [CrossRef] [PubMed]
- Montero, C.A.; Gimferrer, J.M.; Baldo, X.; Ramirez, J. Mediastinal metastasis of ovarian carcinoma. Eur. J. Obstet. Gynecol. Reprod. Biol. 2000, 91, 199–200. [Google Scholar] [CrossRef] [PubMed]
- Inoue, E.; Yotsumoto, T.; Inoue, Y.; Fukami, T.; Kitani, M.; Hirano, Y.; Nagase, M.; Morio, Y. Mediastinal metastasis from ovarian serous carcinoma 29 years after initial treatment. Respir. Med. Case Rep. 2020, 29, 101003. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Zannoni, G.F.; Vellone, V.G.; Distefano, M.G.; Fadda, G.; Scambia, G. Ovarian serous carcinoma presenting with mediastinal lymphadenopathy 20 months before the intraabdominal mass: Role of immunohistochemistry. Gynecol. Oncol. 2007, 104, 497–500. [Google Scholar] [CrossRef] [PubMed]
- Sołek, J.M.; Zielińska, A.; Sobczak, M.; Czernek, U.; Kubiak, R.; Kordek, R.; Jesionek-Kupnicka, D. Serous borderline tumor with distant mediastinal metastasis? An Exceptional presentation of ovarian tumor. Pol. J. Pathol. 2021, 72, 272–276. [Google Scholar] [CrossRef] [PubMed]
- Miura, H.; Miura, J.; Goto, S.; Yamamoto, T. Ovarian serous carcinoma in which mediastinal recurrence of the cancer was resected 16 years after surgery: A case report. Respirol. Case Rep. 2022, 10, e0988. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Nasioudis, D.; Ko, E.M.; Haggerty, A.F.; Giuntoli, R.L.; Burger, R.A.; Morgan, M.A.; Latif, N.A. Isolated distant lymph node metastases in ovarian cancer. Should a new substage be created? Gynecol. Oncol. Rep. 2019, 28, 86–90. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Zang, R.Y.; Zhang, Z.Y.; Cai, S.M.; Tang, M.Q.; Chen, J.; Li, Z.T. Epithelial ovarian cancer presenting initially with extraabdominal or intrahepatic metastases: A preliminary report of 25 cases and literature review. Am. J. Clin. Oncol. 2000, 23, 416–419. [Google Scholar] [CrossRef] [PubMed]
- Deng, K.; Yang, C.; Tan, Q.; Song, W.; Lu, M.; Zhao, W.; Lou, G.; Li, Z.; Li, K.; Hou, Y. Sites of distant metastases and overall survival in ovarian cancer: A study of 1481 patients. Gynecol. Oncol. 2018, 150, 460–465. [Google Scholar] [CrossRef] [PubMed]
- Hjerpe, E.; Staf, C.; Dahm-Kähler, P.; Stålberg, K.; Bjurberg, M.; Holmberg, E.; Borgfeldt, C.; Tholander, B.; Hellman, K.; Kjølhede, P.; et al. Lymph node metastases as only qualifier for stage IV serous ovarian cancer confers longer survival than other sites of distant disease—A Swedish Gynecologic Cancer Group (SweGCG) study. Acta Oncol. 2018, 57, 331–337. [Google Scholar] [CrossRef] [PubMed]
- Pergialiotis, V.; Androutsou, A.; Papoutsi, E.; Bellos, I.; Thomakos, N.; Haidopoulos, D.; Rodolakis, A. Survival outcomes of ovarian cancer patients treated with secondary cytoreductive surgery for isolated lymph node recurrence: A systematic review of the literature. Int. J. Surg. 2019, 69, 61–66. [Google Scholar] [CrossRef] [PubMed]
- Uzan, C.; Morice, P.; Rey, A.; Pautier, P.; Camatte, S.; Lhommé, C.; Haie-Meder, C.; Duvillard, P.; Castaigne, D. Outcomes after combined therapy including surgical resection in patients with epithelial ovarian cancer recurrence(s) exclusively in lymph nodes. Ann. Surg. Oncol. 2004, 11, 658–664. [Google Scholar] [CrossRef] [PubMed]
- Fotopoulou, C. Intrathoracic surgery as part of primary cytoreduction for advanced ovarian cancer: The evolution of a “pelvic” surgeon. Gynecol. Oncol. 2023, 170, A1–A3. [Google Scholar] [CrossRef] [PubMed]
- Pessini, S.A.; Carvalho, J.P.; dos Reis, R.; Filho, A.L.d.S.; Primo, W.Q.S.P. Fertility preservation in gynecologic cancer patients. Rev. Bras. Ginecol. Obs. 2023, 45, 161–168. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
First Author Year, | Nr of Patients | Age of Patients (Range) | Serous Histology | Other Histology | Primary Disease | Recurrence | Time Period from Initial Diagnosis to Recurrence (Years) | Main Symptoms | Primary Disease Treatment | Mediastinal Resection | LN Treated with Systematic Therapy | Follow-Up (mo) | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Chemo Therapy | Surgical Debulking | ||||||||||||
Case series | |||||||||||||
Moran, 2005 [10] | 3 | Median: 40 (33–50) | 3 | 0 | 0 | 3 | NM | None | 0 | 3 | 3 | 0 | Median: 12 (6–18) |
Blanchard, 2007 [8] | 4 | Median: 62.5 (58–67) | NM | NM | 0 | 4 | 4.5 | None | 0 | 4 | 0 | 0 | Median: 75.5 (19–132) |
Case reports | |||||||||||||
Oguchi, 1998 [9] | 1 | 41 | 1 | 0 | 0 | 1 | Dyspnea | 0 | 1 | 1 | 0 | 5 | |
Montero, 2000 [11] | 1 | 46 | 1 | 0 | 0 | 1 | 0 | None | 0 | 1 | 1 (VATS) | 0 | 6 |
Zannoni, 2006 [13] | 1 | 63 | 1 | 0 | 1 | 0 | 20 months earlier | Dyspnea | 1 (NACT) | 1 | 1 | 0 | 1.5 |
Scarci, 2010 [3] | 1 | 71 | 1 | 0 | 1 | 0 | Dyspnea | 1 (NACT) | 1 | 0 | 1 | 10 | |
Dhilon, 2016 [7] | 1 | 61 | 1 | 0 | 0 | 1 | Bilateral mass | 0 | 1 | 1 | 0 | 36 | |
Inoue, 2020 [12] | 1 | 67 | 1 | 0 | 0 | 1 | 29 | None | 1 | 1 | 1 (VATS) | 0 | 12 |
Solek, 2021 [14] | 1 | 48 | 0 | 1 | 0 | 1 | Dyspnea | 0 | 1 | 0 | 1 | 7 | |
Miura, 2022 [15] | 1 | 88 | 1 | 0 | 0 | 1 | 16 | None | 1 | 1 | 1 | 0 | 10 |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Psomiadou, V.; Fotiou, A.; Iavazzo, C. Mediastinal Metastasis Isolated in Ovarian Cancer: A Systematic Review. Life 2024, 14, 1098. https://doi.org/10.3390/life14091098
Psomiadou V, Fotiou A, Iavazzo C. Mediastinal Metastasis Isolated in Ovarian Cancer: A Systematic Review. Life. 2024; 14(9):1098. https://doi.org/10.3390/life14091098
Chicago/Turabian StylePsomiadou, Victoria, Alexandros Fotiou, and Christos Iavazzo. 2024. "Mediastinal Metastasis Isolated in Ovarian Cancer: A Systematic Review" Life 14, no. 9: 1098. https://doi.org/10.3390/life14091098