Evaluation of Pre-Therapeutic Assessment in Endometrial Cancer Staging
Abstract
:1. Introduction
2. Material and Method
2.1. Population
2.2. Statistical Method
3. Results
3.1. Population
3.2. Concordance between MRI and Final Histopathological Examination
3.3. Concordance between Endometrial Biopsy and Final Histopathological Examination
3.4. Indication of Lymphadenectomy
4. Discussion
4.1. Concordance between MRI and Final Histopathological Examination
4.2. Concordance between Endometrial Biopsy and Final Histopathological Examination
4.3. Strength and Limitation
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Age (years old) (Median, SD) (N = 183) | 66.1 (10.1) |
BMI (kg/m2) (Median, SD) (N = 183) | 39 (14.5) |
ASA score (n, %) (N = 170) | |
1 | 29 (17.1) |
2 | 76 (44.7) |
3 | 61 (35.9) |
4 | 4 (2.4) |
Menopausal status (n, %) (N = 182) | |
Premenopausal | 6 (3.3) |
Postmenopausal | 176 (96.7) |
Hormone replacement therapy (n, %) (N = 155) | 28 (18.1) |
Tamoxifen (n, %) (N = 182) | 12 (6.6) |
Parity (median, range) (N = 171) | 2 (0–9) |
Abnormal bleedings (n, %) (N = 183) | 166 (90.7) |
Diabetes (n, %) (N = 183) | 40 (21.9) |
FIGO Stage | Final Histopathological Examination (n, %) | N (n, %) | ||||
---|---|---|---|---|---|---|
IA | IB | II | III–IV | |||
MRI | IA | 36 (37.5) | 36 (37.5) | 11 (11.5) | 13 (13.5) | 96 (53.9) |
IB | 21 (50.0) | 11 (26.2) | 5 (11.9) | 5 (11.9) | 42 (23.6) | |
II | 3 (17.6) | 4 (23.5) | 4 (23.5) | 6 (35.3) | 17 (9.6) | |
III–IV | 6 (26.1) | 6 (26.1) | 3 (13.0) | 8 (34.8) | 23 (12.9) | |
N (n, %) | 66 (37.1) | 57 (32.0) | 23 (12.9) | 32 (18.0) | 178 |
Final Histopathological Examination (n, %) | ||||
---|---|---|---|---|
N− | N+ | |||
MRI | N− | 101 (87.1) | 15 (12.9) | 116 |
N+ | 8 (66.7) | 4 (33.3) | 12 | |
109 | 19 |
Tumor Grade | Final Histopathological Examination (n, %) | N (n, %) | |||
---|---|---|---|---|---|
1 | 2 | 3 | |||
Endometrial biopsy | 1 | 37 (49.3) | 35 (46.7) | 3 (4.0) | 75 (43.4) |
2 | 5 (7.6) | 49 (74.2) | 12 (18.2) | 66 (38.2) | |
3 | 1 (3.1) | 6 (18.8) | 25 (78.1) | 32 (18.5) | |
N (n, %) | 43 (24.9) | 90 (52.0) | 40 (23.1) | 173 |
Tumor Grade | Final Histopathological Examination (n, %) | N (n, %) | |||
---|---|---|---|---|---|
1 | 2 | 3 | |||
Cornier pipelle (n, %) | 1 | 13 (34.2) | 22 (57.9) | 3 (7.9) | 38 |
2 | 2 (6.5) | 22 (71.0) | 7 (22.6) | 31 | |
3 | 0 | 0 | 12 (100) | 12 | |
Hysteroscopy (n, %) | 1 | 24 (64.9) | 13 (35.1) | 0 | 37 |
2 | 3 (8.6) | 27 (77.1) | 5 (14.3) | 35 | |
3 | 1 (5.0) | 6 (30.0) | 13 (65.0) | 20 | |
N (n, %) | 43 (24.9) | 90 (52.0) | 40 (23.1) | 173 |
Indication of Lymphadenectomy on Postoperative Data (n/N) | |||||
---|---|---|---|---|---|
Indication of lymphadenectomy on preoperative data (n/N) | Indicated | Not Indicated | Performed | Nodal Metastasis | |
Indicated | 50/66 | 16/66 | 58/66 | 13/58 | |
Not indicated | 42/106 | 64/106 | 70/106 | 6/70 |
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Bouche, C.; Gomes David, M.; Salleron, J.; Rauch, P.; Leufflen, L.; Buhler, J.; Marchal, F. Evaluation of Pre-Therapeutic Assessment in Endometrial Cancer Staging. Diagnostics 2020, 10, 1045. https://doi.org/10.3390/diagnostics10121045
Bouche C, Gomes David M, Salleron J, Rauch P, Leufflen L, Buhler J, Marchal F. Evaluation of Pre-Therapeutic Assessment in Endometrial Cancer Staging. Diagnostics. 2020; 10(12):1045. https://doi.org/10.3390/diagnostics10121045
Chicago/Turabian StyleBouche, Caroline, Manuel Gomes David, Julia Salleron, Philippe Rauch, Léa Leufflen, Julie Buhler, and Frédéric Marchal. 2020. "Evaluation of Pre-Therapeutic Assessment in Endometrial Cancer Staging" Diagnostics 10, no. 12: 1045. https://doi.org/10.3390/diagnostics10121045
APA StyleBouche, C., Gomes David, M., Salleron, J., Rauch, P., Leufflen, L., Buhler, J., & Marchal, F. (2020). Evaluation of Pre-Therapeutic Assessment in Endometrial Cancer Staging. Diagnostics, 10(12), 1045. https://doi.org/10.3390/diagnostics10121045