A Systematic Review of Cerebral Functional Near-Infrared Spectroscopy in Chronic Neurological Diseases—Actual Applications and Future Perspectives
Abstract
:1. Introduction
2. Methods
3. fNIRS in Parkinson’s Disease
3.1. Deep Brain Stimulation
3.2. Walking and Dual Walking Task
4. fNIRS in Alzheimer’s Disease and Mild Cognitive Impairment
4.1. Tissue Oxygenation Monitoring
4.2. Functional Resting-State
4.3. Cognitive Tasks–Memory Task
4.4. Cognitive Tasks–Verbal Fluency Task
4.5. Cognitive Tasks–Visuospatial Task
4.6. Ecological Applications
4.7. Longitudinal Monitoring
5. fNIRS in Multiple Sclerosis
6. Discussion
7. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Parkinson’s Disease (PD) | |||||||||
---|---|---|---|---|---|---|---|---|---|
fNIRS Device | Patient Info | Study Type | Integrated Clinical Outcomes | Cortical Areas | Performed Task | Ch. | Multimodal Integration | ||
Deep Brain Stimulation | Sakatani et al., 1999 | NIRO-300 (Hamamatsu Photonics K.K., Japan) | 5 PD, 1 essential tremor patient | cross-sectional | UPDRS, tremor rating scale | bilateral PFC | tissue oxygenation monitor | 1 | no |
Morishita et al., 2016 | FOIRE-3000 (Shimadzu Corporation, Kyoto, Japan) | 6 PD | longitudinal | UPDRS | primary motor cortex | unilateral hand movement | 48 | no | |
Mayer et al., 2016 | ETG-4000 (Hitachi Medical Co., Tokyo, Japan) | 9 PD, 8 HC | cross-sectional (*) | UPDRS | lateral and medial FC (bilateral hemispheres) | spatial-delayed response task (working memory task) | 22 | no | |
Eggebrecht et al., 2014 | custom HD-DOT system | (18 HC) 3 PD | cross-sectional | n.d. | almost whole-head (temporal, occipital cortex) | auditory words, resting-state | 1200+ | T1- and T2-MRI, fMRI (not performed on PD patients) | |
Walking and Dual Walking Task | Mahoney et al., 2016 | fNIR Imager 1000 (fNIR Devices LLC, Protomac, MD, USA) | 26 PD, 117 mild PD, 126 HC | cross-sectional | n.d. | PFC | postural stability control task | 16 | instrumented walkway |
Nieuwhof et al., 2016 | PortLite (Artinis Medical Systems, Elst, The Netherlands) | 14 PD | cross-sectional | n.d. | bilateral PFC | counting forward, serially subtracting, reciting digit spans | 3 | instrumented walkway with pressure sensors | |
Cornejo et al., 2018 | PortLite (Artinis Medical Systems, The Netherlands) | 20 PD | cross-sectional | n.d. | dorsolateral PFC and anterior PFC (bilateral BA10) | over-ground and treadmill walking | 3 | instrumented treadmill, 3D-accelerometers | |
Stuart et al., 2019 | Oxymon (Artinis Medical Systems, The Netherlands) | 24 PD, 19 HOA, 25 HYA | cross-sectional | n.d. | PFC (BA9 and BA10) | turning-in-place task | n.d. | no | |
Maidan et al., 2015 | Oxymon MKIII (Artinis Medical Systems, The Netherlands) | 11 PD, 11 HC | cross-sectional | n.d. | PFC (bilateral BA10) | walking with anticipated and unanticipated turns (WT) | 6 | no | |
Maidan et al., 2016 | PortLite (Artinis Medical Systems, Elst, The Netherlands) | 68 PD, 38 HC | cross-sectional | n.d. | dorsolateral PFC and anterior PFC (bilateral BA10) | obstacle negotiation, WT, DWT | 3 | instrumented walkway with pressure sensors | |
Maidan et al., 2017 | PortLite (Artinis Medical Systems, Elst, The Netherlands) | 49 PD | cross-sectional | n.d. | dorsolateral PFC and anterior PFC (bilateral BA10) | usual walking and turning (WT) | 3 | instrumented walkway with pressure sensors | |
Maidan et al., 2018 | PortLite (Artinis Medical Systems, Elst, The Netherlands) | 64 PD | longitudinal | UPDRS | dorsolateral PFC and anterior PFC (bilateral BA10) | treadmill training (obstacle negotiation, WT, DWT) | 3 | instrumented walkway with pressure sensors |
Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD) | |||||||||
---|---|---|---|---|---|---|---|---|---|
fNIRS Device | Patient Info | Study Type | Integrated Clinical Outcomes | Cortical Areas | Performed Task | Ch. | Multimodal Integration | ||
Tissue Oxygenation Monitoring | Marmarelis et al., 2017 | N.D. (Hamamatsu Photonics K.K., Japan) | (46) 38 aMCI, (22) 14 HC | cross-sectional | n.d. | PFC | tissue oxygenation monitor | n.d. | TCD, finger photo-plethysmography, capnography |
Viola et al., 2013 | custom NIRS device (T-NIRS EVO II) | 21 aMCI, 10 HC | cross-sectional | MMSE | bilateral frontal and parieto-temporal cortex | tissue oxygenation monitor | 1 | TCD | |
van Beek et al., 2012 | Oxymon (Artinis Medical Systems, Zetten, The Netherlands) | 21 mild to moderate AD, 20 HC | cross-sectional | n.d. | bilateral FC | tissue oxygenation monitor during repeated sit-stand manoeuvres | n.d. | TCD, finger photo-plethysmography, ECG | |
Liu et al., 2014 | NIRO-200NX (Hamamatsu Photonics K.K., Japan) | 32 aMCI, 21 HC | cross-sectional (**) | n.d. | n.d. | tissue oxygenation monitor | 2 | color-coded duplex ultrasonography, MRI, sphygmomanometer, pulse oximeter, ECG, capnography | |
Babiloni et al., 2014 | ISS oximeter, Model 96,208 (ISS Inc., Champaign, IL, USA) | 10 aMCI, 10 HC | cross-sectional | MMSE | bilateral PFC | tissue oxygenation monitor under resting-state and hypercapnia conditions | 2 | concurrent NIRS-EEG | |
Bär et al., 2007 | NIRO-500 (Hamamatsu Photonics K.K., Japan) | 17 AD, 17 vascular dementia patients, 20 HOA, 20 HYA | cross-sectional | MMSE | left FC | tissue oxygenation monitor under normocapnia and hypercapnia conditions | 2 | TCD, finger blood pressure monitor | |
Functional Resting-State | Niu et al., 2019 | CW6 (TechEn Inc., Milford, MA, USA) | 23 AD, 25 aMCI, 30 HC | cross-sectional | MMSE, AVLT, MoCA | whole-head | resting-state | 46 | no |
Zeller et al., 2019 | ETG-4000 (Hitachi Medical Co., Tokyo, Japan) | 54 MCI, 61 HOA, 25 HYA | cross-sectional | DemTect, RCFT, RWT, VLMT, TAP, WMS-R | frontal and parietal cortex | resting-state | 96 | no | |
Bu et al., 2019 | NirSmart (Danyang Huichuang Medical Equipment Co., PR China) | 26 MCI, 28 HC | cross-sectional | MMSE, MoCA | bilateral PFC, motor and occipital cortex | resting-state | 14 | no | |
Nguyen et al., 2019 | Custom fNIRS device | 42 MCI, 42 HC | cross-sectional | MMSE | PFC | resting-state, oddball task, 1-back task, letter and category fluency task | 4 | no | |
Cognitive Task - Memory Task | Niu et al., 2013 | ETG-4000 (Hitachi Medical Co., Tokyo, Japan) | 8 aMCI, 16 HC | cross-sectional | MMSE, AVLT, BNT, Stroop Test | bilateral frontal, parietal and temporal cortex | n-back task (WMT) | 54 | no |
Yeung et al., 2016 | OEG-SpO2 system (Spectratech Inc., Tokyo, Japan) | 10 aMCI, 16 MCI, 26 HC | cross-sectional | n.d. | bilateral PFC | n-back task | 16 | no | |
Uemura et al., 2016 | FOIRE-3000 (Shimadzu Corporation, Kyoto, Japan) | 64 aMCI, 66 HC | cross-sectional | n.d. | bilateral prefrontal and frontopolar cortex (BA9, 46, 10) | memory encoding and delayed retrieval task | 22 | no | |
Kato et al., 2017 | ETG-4000 (Hitachi Medical Co., Tokyo, Japan) | 42 AD, 98 intermediate group (65 high score HDS-R/MMSE, 33 low score HDS-R/MMSE), 91 HC | cross-sectional | MMSE, HDS-R, Z-score of VSRAD | FC, dorsolateral PFC, bilateral parietal cortex | single-word presentation task | 44 | MRI | |
Ateş et al., 2017 | ETG-4000 (Hitachi Medical Co., Tokyo, Japan) | 20 AD, 20 HC | cross-sectional | n.d. | dorsolateral and ventral PFC | emotional working memory (n-back task) | 24 | no | |
Oboshi et al., 2016 | OEG-16 system (Spectratech Inc., Yokohama, Japan) | 11 early-to-moderate AD, 11 HC (*) | cross-sectional | alfa4beta2 nicotinic receptor tracer [18F]2FA | PFC | visual WMT | 16 | PET | |
Li et al., 2018 | NIRScout (NIRx Medizintechnik GmbH, Germany) | 9 MCI, 13 AD (6 mild AD, 7 moderate to severe AD), 8 HC | cross-sectional | MMSE | FC, bilateral parietal cortex | digit verbal span task | 46 | no | |
Li et al., 2019 | NIRScout (NIRx Medizintechnik GmbH, Germany) | 14 mild AD, 8 HC | cross-sectional | n.d. | FC, bilateral parietal cortex | digit verbal span task | 46 | concurrent fNIRS-EEG | |
Perpetuini et al., 2017 | Imagent (ISS Inc., Champaign, IL, USA) | 11 mild AD, 11 HC | cross-sectional | free and cued selective reminding test | bilateral PFC | free and cued selective reminding test | 17 | no | |
Perpetuini et al., 2019 | Imagent (ISS Inc., Champaign, IL, USA) | 11 mild AD, 11 HC | cross-sectional | CDT | bilateral FC and PFC | CDT, digit span test, Corsi block tapping test | 21 | no | |
Cognitive Task - Verbal Fluency Task (VFT) | Hock et al., 1996 | NIRO-500 (Hamamatsu Photonics K.K., Japan) | (17 HOA, 12 HYA) 19 AD, 19 HC | cross-sectional | n.d. | bilateral PFC and parietal cortex | calculation task | 2 | no |
Hock et al., 1997 | NIRO-500 (Hamamatsu Photonics K.K., Japan) | 29 mild AD, 27 HC | cross-sectional | n.d. | frontal, prefrontal and parietal cortex | letter fluency, modified Stroop colour word interference test | 2 | concurrent NIRS-PET | |
Fallgatter et al., 1997 | Critikon 2020 Cerebral Redox Monitor (Johnson and Johnson Medical) | 10 AD, 10HC | cross-sectional | n.d. | bilateral PFC | letter and category fluency tasks | 4 | no | |
Herrmann et al., 2008 | ETG-100 (Hitachi Medical Co., Tokyo, Japan) | 16 AD, 16 HC | cross-sectional | n.d. | bilateral PFC | letter and category fluency tasks | 24 | no | |
Arai et al., 2006 | ETG-7000 (Hitachi Medical Co., Tokyo, Japan) | 15 AD, 15 MCI, 32 HC | cross-sectional | MMSE | FC, occipital cortex, bilateral parietal cortex | letter fluency task | 84 | no | |
Yeung et al., 2016 | OEG-SpO2 system (Spectratech Inc., Tokyo, Japan) | 10 aMCI, 16 MCI, 26 HC | cross-sectional | BNT, HKLLT, RCFT, STT | bilateral PFC | category fluency task | 16 | no | |
Yap et al., 2017 | OT-R40 fNIRS topography system (Hitachi Medical Co., Tokyo, Japan) | 18 mild AD, 12 MCI, 31 HC | cross-sectional | MMSE | PFC, partial temporal cortex | semantic fluency task | 52 | no | |
Doi et al., 2013 | OEG-16 system (Spectratech Inc., Yokohama, Japan) | 16 MCI | cross-sectional | modified Stroop colour and word test | bilateral PFC | normal and dual-task walking (letter fluency task) | 16 | no | |
Katzorke et al., 2018 | ETG-4000 (Hitachi Medical Co., Tokyo, Japan) | 55 MCI, 55 HC | cross-sectional | n.d. | FC, PFC and temporal cortex | letter and category fluency task, control condition | 52 | no | |
Metzger et al., 2016 | ETG-4000 (Hitachi Medical Co., Tokyo, Japan) | 8 bvFTD, 8 AD, 8 HC | cross-sectional | n.d. | bilateral PFC and temporal cortex | letter and category fluency task, control condition | 22 | no | |
Visuospatial Task | Kito et al., 2014 | FOIRE-3000 (Shimadzu Corporation, Kyoto, Japan) | 30 patients with depression, 28 AD, 33 HC | cross-sectional | MMSE, CDR, FAB, HAMD | FC and parietal cortex | letter fluency task, Benton Judgment of Line Orientation | 44 | no |
Zeller et al., 2010 | ETG-100 (Hitachi Medical Co., Tokyo, Japan) | 13 mild to moderate AD, 13 HC | cross-sectional | n.d. | parietal cortex | modified version of the Benton Line Orientation Task | 24 | no | |
Ecological Applications | Tomioka et al., 2009 | ETG-4000 (Hitachi Medical Co., Tokyo, Japan) | 12 AD, 14 HC | cross-sectional | n.d. | bilateral PFC and temporal cortex | collision avoidance (driving task) | 52 | driving simulator |
Shimizu et al., 2018 | LABNIRS (Shimadzu Corporation, Kyoto, Japan) | 45 MCI (35 intervention group, 10 control group) | longitudinal | FAB, CS-30 test, one-leg standing test, sit-and-reach test, timed Up & Go test | bilateral PFC | movement music therapy (physical-cognitive task) | 45 | digital sit-and-reach instrument box, digital handgrip dynamometer, walking measurement instrument | |
Longitudinal Applications | van Beek et al., 2010 | Oxymon (Artinis Medical Systems, The Netherlands) | 21 AD, 20 HC | longitudinal | n.d. | bilateral FC | tissue oxygenation monitor during postural change task | n.d. | TCD, pulse-oximeter, capnography, finger photo-plethysmography |
Araki et al., 2014 | ETG-4000 (Hitachi Medical Co., Tokyo, Japan) | 37 moderate-to-severe AD (19 experimental group, 18 control group) | longitudinal | MMSE, CDT, CGI-I scale, NPI, J-ZBI | FC | letter fluency task | 22 | no | |
Metzger et. al, 2015 | ETG-4000 (Hitachi Medical Co., Tokyo, Japan) | 24 AD | longitudinal | MMSE, immediate and delayed word list recall trials | bilateral PFC and temporal cortex | letter and category fluency task | 44 | no | |
Viola et al., 2014 | custom NIRS instrument (T-NIRS EVO II) | 25 mild AD | longitudinal | MMSE, AVLT | bilateral frontal and parieto-temporal cortex | tissue oxygenation monitor | 1 | no | |
Vermeij et al., 2017 | Oxymon MKIII (Artinis Medical Systems, The Netherlands,) | 14 MCI, 21 HC | longitudinal | n.d. | bilateral PFC | verbal n-back task | n.d. | finger photoplethysmography, ECG | |
Polak et al., 2017s | ETG-4000 and ETG-100 (Hitachi Medical Co., Tokyo, Japan) | 530 AD, 74 MCI | longitudinal | MMSE, Anxiety Status Inventory, Bayer Activities of Daily Living Scale, BDI-II, DemTect, Edinburgh test of handedness, GDS, HAMD, RCFT, RWT, VLMT, TAP, WMS-R | prefrontal and parietal cortex | resting-state, letter and category fluency task, trail making test, angle discrimination test | 52 and 24 | blood test, vagus somatosensory evoked potentials (EEG), intima media thickness, left ventricular ejection fraction, MRI, PET, CSF analysis |
Multiple Sclerosis (MS) | ||||||||
---|---|---|---|---|---|---|---|---|
fNIRS Device | Patient Info | Study Type | Integrated Clinical Outcomes | Investigated Cortical Areas | Performed Task | Ch. | Multimodal Integration | |
Chaparro et al., 2017 | fNIR Imager 1000 (fNIR Devices LLC, Protomac, MD, USA) | 10 MS, 12 HC | cross-sectional | RBANS, SPPB | PFC | walking while talking with/without partial body weight support (WT, DWT) | 16 | instrumented treadmill |
Saleh et al., 2018 | NIRSport (NIRx Medizintechnik GmbH, Germany) | 14 RRMS, 14 HC | cross-sectional | BVMT-R, CVLT-II, SDMT, T25FW | bilateral premotor and supplementary motor areas | serial 7′s subtraction cognitive task, walking and DWT | 12 | no |
Hernandez et al., 2016 | fNIR Imager 1000 (fNIR Devices LLC, Protomac, MD, USA) | 8 MS, 8 HC | cross-sectional | EDSS | PFC | walking without/while talking (WT, DWT) | 16 | instrumented walkway |
Hernandez et al., 2019 | fNIR Imager 1000 (fNIR Devices LLC, Protomac, MD, USA) | 10 MS, 12 HC (*) | cross-sectional | n.d. | PFC | reciting alternate letters, virtual beam walking without/while talking | 16 | instrumented treadmill |
Borragán et al., 2018 | BrainSight NIRS V2.3b16 (Rogue Research Inc., Canada) | 10 RRMS, 11 HC (*) | cross-sectional | VASf | dorsolateral and ventrolateral PFC, inferior parietal cortex | TloadDback (dual working memory task) | 24 | polysomnography (including EEG, EOG, EMG, ECG, abdominal and thoracic belts, oronasal airflow and thermocouple, finger pulse oximeter) |
Jimenez et al., 2014 | CW5 (TechEn Inc., Milford, MA, USA) | 4 RRMS, 2 SPMS, 2 MS, 1 CIS, 1 MS (unspecified), 8 HC | cross-sectional | n.d. | motor cortex | unilateral finger tapping, resting-state | n.d. | no |
Wolff et al., 2019 | NIRSport (NIRx Medical Technologies LLC, NY, USA) | 26 RRMS, 18 SPMS, 6 PPMS | cross-sectional | BDI, CR10 scale, FSMC, SCS-K-D | PFC (BA10) | isometric contraction task | 22 | Hand dynamometer |
Stojanovic-Radic et al., 2015 | DYNOT Imaging System, Model 264 (NIRx Medical Technologies LLC, Glen Head, NY, USA) | 13 MS, 12 HC (*) | cross-sectional | n.d. | bilateral superior frontal and middle frontal gyri (BA10) | n-back task (working memory task) | 900 | no |
Molinari et al., 2014 | NIRO-200 (Hamamatsu Photonics K.K., Japan) | 22 RRMS, 10 other neurological disease, 22 HC (*) | cross-sectional | n.d. | FC | monitoring during ozone autohemotherapy | 2 | transcranial doppler, ozone autohemotherapy |
Molinari et al., 2017 | NIRO-200 (Hamamatsu Photonics K.K., Japan) | 10 RRMS, 10 HC (*) | cross-sectional | n.d. | bilateral FC | monitoring during ozone autohemotherapy | 2 | ozone autohemotherapy |
Yang and Dunn, 2015 | ISS OxiplexTS (ISS Inc., Champaign, IL, USA) | 51 RRMS, 16 SPMS, 15 PPMS, 3 CIS, 19 HC | cross-sectional | EDSS, SDMT, T25FT, 9 hole peg test | bilateral FC | tissue oxygenation monitor | 4 | concurrent NIRS-MRI |
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Bonilauri, A.; Sangiuliano Intra, F.; Pugnetti, L.; Baselli, G.; Baglio, F. A Systematic Review of Cerebral Functional Near-Infrared Spectroscopy in Chronic Neurological Diseases—Actual Applications and Future Perspectives. Diagnostics 2020, 10, 581. https://doi.org/10.3390/diagnostics10080581
Bonilauri A, Sangiuliano Intra F, Pugnetti L, Baselli G, Baglio F. A Systematic Review of Cerebral Functional Near-Infrared Spectroscopy in Chronic Neurological Diseases—Actual Applications and Future Perspectives. Diagnostics. 2020; 10(8):581. https://doi.org/10.3390/diagnostics10080581
Chicago/Turabian StyleBonilauri, Augusto, Francesca Sangiuliano Intra, Luigi Pugnetti, Giuseppe Baselli, and Francesca Baglio. 2020. "A Systematic Review of Cerebral Functional Near-Infrared Spectroscopy in Chronic Neurological Diseases—Actual Applications and Future Perspectives" Diagnostics 10, no. 8: 581. https://doi.org/10.3390/diagnostics10080581