Evaluation of FDG-PET/CT Use in Children with Suspected Infection or Inflammation
Abstract
:1. Introduction
2. Patients and Methods
2.1. Patients
2.2. FDG-PET/CT Scanning Procedure
2.3. Data Sources
2.4. Diagnostic and Follow-Up Scans
2.5. Analysis
2.5.1. Diagnostic Accuracy and Reference Standard
2.5.2. Scan Consequence
2.5.3. Incidental Findings
2.5.4. Statistical Analysis
3. Results
3.1. Selection Process
3.2. Diagnostic Scans
3.3. Follow-Up Scans
3.4. Relationship between CRP, Fever and Positive Scans
3.5. Incidental Findings
3.6. Clinical Examples
4. Discussion
5. Conclusions and Recommendation
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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n | % | Median (IQR) | |
---|---|---|---|
Characteristics | |||
Patients | 59 | ||
Age at first scan (yrs) | 12 (5–15) | ||
Female | 37 | (63) | |
No of FDG-PET/CT scans | 64 | ||
diagnostic scans | 50 | (73) | |
follow up scans | 14 | (27) | |
>1 scan, No of patients | 4 | ||
Amsterdam University Medical Center | 21 | (33) | |
University Medical Center Utrecht | 17 | (27) | |
Erasmus University Medical Center | 19 | (30) | |
Leiden University Medical Center | 5 | (8) | |
Alrijne Hospital Leiderdorp | 2 | (3) |
n | % | Median (IQR) | |
---|---|---|---|
Diagnostic scans and patients | 48 | ||
CRP in week before scan (mg/L) | 46 | (96) | 44 (9–120) |
Fever > 38.3 in week before scan | 19 | (40) | |
Preceding diagnostics | |||
Serology (any lab test) | 48 | (100) | |
Radiology | |||
Chest X ray | 26 | (54) | |
Other radiological examination | 14 | (29) | |
Ultrasonography | 37 | (77) | |
MRI | 17 | (35) | |
CT | 11 | (23) | |
Bone Scintigraphy | 1 | (2) | |
Microbiology | |||
Blood culture | 34 | (71) | |
Urine culture | 15 | (31) | |
Sputum/nose/throat culture | 12 | (25) | |
Faeces culture/PCR testing | 13 | (27) | |
Joint fluid culture | 2 | (4) | |
Cerebrospinal fluid culture | 6 | (13) | |
Cytology/histology | 12 | (25) |
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Ropers, F.G.; van Mossevelde, R.M.P.; Bleeker-Rovers, C.P.; van Velden, F.H.P.; van Assema, D.M.E.; Adam, J.A.; Lam, M.G.E.H.; Tolboom, N.; Dekkers, O.M.; de Geus-Oei, L.-F.; et al. Evaluation of FDG-PET/CT Use in Children with Suspected Infection or Inflammation. Diagnostics 2020, 10, 715. https://doi.org/10.3390/diagnostics10090715
Ropers FG, van Mossevelde RMP, Bleeker-Rovers CP, van Velden FHP, van Assema DME, Adam JA, Lam MGEH, Tolboom N, Dekkers OM, de Geus-Oei L-F, et al. Evaluation of FDG-PET/CT Use in Children with Suspected Infection or Inflammation. Diagnostics. 2020; 10(9):715. https://doi.org/10.3390/diagnostics10090715
Chicago/Turabian StyleRopers, Fabienne G., Robin M. P. van Mossevelde, Chantal P. Bleeker-Rovers, Floris H. P. van Velden, Danielle M. E. van Assema, Judit A. Adam, Marnix G. E. H. Lam, Nelleke Tolboom, Olaf M. Dekkers, Lioe-Fee de Geus-Oei, and et al. 2020. "Evaluation of FDG-PET/CT Use in Children with Suspected Infection or Inflammation" Diagnostics 10, no. 9: 715. https://doi.org/10.3390/diagnostics10090715