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Volume 11
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10.3390/diagnostics11101858
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Article

Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings

by
Kentaro Yamao
1,*,
Masakatsu Tsurusaki
2,
Kota Takashima
1,
Hidekazu Tanaka
1,
Akihiro Yoshida
1,
Ayana Okamoto
1,
Tomohiro Yamazaki
1,
Shunsuke Omoto
1,
Ken Kamata
1,
Kosuke Minaga
1,
Mamoru Takenaka
1,
Takaaki Chikugo
3,
Yasutaka Chiba
4,
Tomohiro Watanabe
1 and
Masatoshi Kudo
1
1
Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, Japan
2
Department of Diagnostic Radiology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, Japan
3
Department of Pathology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, Japan
4
Clinical Research Center, Kindai University Hospital, Osaka-Sayama, Osaka 589-8511, Japan
*
Author to whom correspondence should be addressed.
Diagnostics 2021, 11(10), 1858; https://doi.org/10.3390/diagnostics11101858
Submission received: 5 August 2021 / Revised: 30 September 2021 / Accepted: 5 October 2021 / Published: 9 October 2021
(This article belongs to the Special Issue Diagnosis of Pancreatic Cancer)
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Abstract

Background: Pancreatic cancer (PC) exhibits extremely rapid growth; however, it remains largely unknown whether the early stages of PC also exhibit rapid growth speed equivalent to advanced PC. This study aimed to investigate the natural history of early PCs through retrospectively assessing pre-diagnostic images. Methods: We examined the data of nine patients, including three patients with carcinoma in situ (CIS), who had undergone magnetic resonance cholangiopancreatography (MRCP) to detect solitary main pancreatic duct (MPD) stenosis >1 year before definitive PC diagnosis. We retrospectively analyzed the time to diagnosis and first-time tumor detection from the estimated time point of first-time MPD stenosis detection without tumor lesion. Results: The median tumor size at diagnosis and the first-time tumor detection size were 14 and 7.5 mm, respectively. The median time to diagnosis and first-time tumor detection were 26 and 49 months, respectively. Conclusions: No studies have investigated the PC history, especially that of early PCs, including CIS, based on the initial detection of MPD stenosis using MRCP. Assessment of a small number of patients showed that the time to progression can take several years in the early PC stages. Understanding this natural history is very important in the clinical setting.
Keywords: carcinoma in situ; computed tomography; early diagnosis; magnetic resonance cholangiopancreatography; natural history; pancreatic carcinoma carcinoma in situ; computed tomography; early diagnosis; magnetic resonance cholangiopancreatography; natural history; pancreatic carcinoma

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MDPI and ACS Style

Yamao, K.; Tsurusaki, M.; Takashima, K.; Tanaka, H.; Yoshida, A.; Okamoto, A.; Yamazaki, T.; Omoto, S.; Kamata, K.; Minaga, K.; et al. Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings. Diagnostics 2021, 11, 1858. https://doi.org/10.3390/diagnostics11101858

AMA Style

Yamao K, Tsurusaki M, Takashima K, Tanaka H, Yoshida A, Okamoto A, Yamazaki T, Omoto S, Kamata K, Minaga K, et al. Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings. Diagnostics. 2021; 11(10):1858. https://doi.org/10.3390/diagnostics11101858

Chicago/Turabian Style

Yamao, Kentaro, Masakatsu Tsurusaki, Kota Takashima, Hidekazu Tanaka, Akihiro Yoshida, Ayana Okamoto, Tomohiro Yamazaki, Shunsuke Omoto, Ken Kamata, Kosuke Minaga, and et al. 2021. "Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings" Diagnostics 11, no. 10: 1858. https://doi.org/10.3390/diagnostics11101858

APA Style

Yamao, K., Tsurusaki, M., Takashima, K., Tanaka, H., Yoshida, A., Okamoto, A., Yamazaki, T., Omoto, S., Kamata, K., Minaga, K., Takenaka, M., Chikugo, T., Chiba, Y., Watanabe, T., & Kudo, M. (2021). Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings. Diagnostics, 11(10), 1858. https://doi.org/10.3390/diagnostics11101858

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