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Diagnostics
Volume 11
Issue 5
10.3390/diagnostics11050830
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Article

Cell Adhesion Molecule 1 (CADM1) Is an Independent Prognostic Factor in Patients with Cutaneous Squamous Cell Carcinoma

by
Natsuko Saito-Sasaki
*,
Yu Sawada
*,
Etsuko Okada
and
Motonobu Nakamura
Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807-8555, Japan
*
Authors to whom correspondence should be addressed.
Diagnostics 2021, 11(5), 830; https://doi.org/10.3390/diagnostics11050830
Submission received: 15 March 2021 / Revised: 26 April 2021 / Accepted: 29 April 2021 / Published: 4 May 2021
(This article belongs to the Section Pathology and Molecular Diagnostics)
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Abstract

Cell adhesion molecular 1 (CADM1) is a multifunctional cell adhesion molecule belonging to the immunoglobulin superfamily, which suppresses malignant solid tumor development. However, the correlation between CADM1 expression and prognosis in cutaneous squamous cell carcinoma (cSCC) patients remains unclear. In a retrospective analysis of 88 patients diagnosed with cSCC at our institution between January 2006 and December 2016, the degree of CADM1 expression in tumor cells was evaluated by immunostaining. Fifty-five and 33 patients had tumors with high and low CADM1 expression, respectively. Low CADM1 expression on the tumor was associated with poor differentiation, whereas the Kaplan–Meier curve and log-lank test indicated a favorable prognosis with high CADM1 expression. Multivariate analysis excluding the effect of the degree of differentiation and clinical stages showed that the hazard ratio (HR) of survival was significantly increased with low CADM1 expression. Thus, CADM1 expression is an independent prognostic factor for cSCC patients.
Keywords: CADM1; cutaneous squamous cell carcinoma; prognosis CADM1; cutaneous squamous cell carcinoma; prognosis

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MDPI and ACS Style

Saito-Sasaki, N.; Sawada, Y.; Okada, E.; Nakamura, M. Cell Adhesion Molecule 1 (CADM1) Is an Independent Prognostic Factor in Patients with Cutaneous Squamous Cell Carcinoma. Diagnostics 2021, 11, 830. https://doi.org/10.3390/diagnostics11050830

AMA Style

Saito-Sasaki N, Sawada Y, Okada E, Nakamura M. Cell Adhesion Molecule 1 (CADM1) Is an Independent Prognostic Factor in Patients with Cutaneous Squamous Cell Carcinoma. Diagnostics. 2021; 11(5):830. https://doi.org/10.3390/diagnostics11050830

Chicago/Turabian Style

Saito-Sasaki, Natsuko, Yu Sawada, Etsuko Okada, and Motonobu Nakamura. 2021. "Cell Adhesion Molecule 1 (CADM1) Is an Independent Prognostic Factor in Patients with Cutaneous Squamous Cell Carcinoma" Diagnostics 11, no. 5: 830. https://doi.org/10.3390/diagnostics11050830

APA Style

Saito-Sasaki, N., Sawada, Y., Okada, E., & Nakamura, M. (2021). Cell Adhesion Molecule 1 (CADM1) Is an Independent Prognostic Factor in Patients with Cutaneous Squamous Cell Carcinoma. Diagnostics, 11(5), 830. https://doi.org/10.3390/diagnostics11050830

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