Malignancy Rate of Indeterminate Findings on FDG-PET/CT in Cutaneous Melanoma Patients
Abstract
:1. Introduction
2. Methods
2.1. Patient Population
2.2. FDG-PET/CT Acquisition
2.3. FDG-PET/CT Image Analysis
2.4. Lesion Selection
2.5. Statistical Analysis
3. Results
3.1. Patient Population
3.2. Indeterminate Findings on FDG-PET/CT Scan
3.3. Additional Imaging Required after FDG-PET/CT Scan
3.4. Standard Assessment of Dignity
3.5. Outcome of Required Additional Imaging after FDG-PET/CT Scan
3.6. Impact of Required Additional Imaging on Clinical Management
3.7. Impact of FDG-PET/CT Indication on Results of Recommended Additional Imaging
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
ICI | Immune Checkpoint Inhibitors |
anti-PD1 | anti-Programmed Death-1 |
anti-CTLA4 | anti-Cytotoxic T-Lymphocyte-Associated Protein 4 |
FDG-PET/CT | 18F-2-Fluor-2-desoxy-D-glucose Positron Emission Tomography/Computed Tomography |
CT | Computed Tomography |
AJCC | American Joint Committee on Cancer |
RECIST | Response Evaluation Criteria in Solid Tumors |
GCP | Good Clinical Practice |
mg | Milligram |
dl | Deciliter |
BMI | Body Mass Index |
GE | General Electric |
PET | Positron Emission Tomography |
OSEM | Ordered Subset Expectation Maximization |
BSREM | Block Sequential Regularized Expectation Maximation |
SPSS | Statistical Package for the Social Sciences |
MRI | Magnetic Resonance Imaging |
DWI | Diffusion Weighted Imaging |
MIP | Maximum Intensity Projection |
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Organ | Radiological Follow Up (CT or MRI) | Biopsy Guide by Ultrasound | Biopsy Guide by a Bronchoscopy, b Colonoscopy or Based on c Mammography | Total |
---|---|---|---|---|
Lymph node | 3 | 7 | 1a | 11 |
Liver | 6 | 1 | 0 | 7 |
Thyroid | 0 | 4 | 0 | 4 |
Breast | 1 | 1 | 1c | 3 |
Cutis/Subcutis | 3 | 3 | 0 | 6 |
Brain | 8 | 0 | 0 | 8 |
Head/Neck | 0 | 2 | 0 | 2 |
Lung | 8 | 0 | 1a | 9 |
Colon | 0 | 0 | 4b | 4 |
Small bowel | 1 | 0 | 0 | 1 |
Bone | 2 | 0 | 0 | 2 |
Kidney | 0 | 1 | 0 | 1 |
Mediastinum | 0 | 0 | 1a | 1 |
Prostate | 0 | 1 | 0 | 1 |
Total | 31 | 20 | 9 | 60 |
Organ | Number of Benign Finding(s) per Organ | Number of Malignant Finding(s) per Organ | Number of Indeterminate Finding(s) per Organ |
---|---|---|---|
Lymph node | 8 | 3 | 11 |
Liver | 2 | 5 | 7 |
Thyroid | 2 | 2 | 4 |
Breast | 1 | 2 | 3 |
Cutis/Subcutis | 4 | 2 | 6 |
Brain | 3 | 5 | 8 |
Head/Neck | 1 | 1 | 2 |
Lung | 6 | 3 | 9 |
Colon | 2 | 2 | 4 |
Small bowel | 1 | 0 | 1 |
Bone | 1 | 1 | 2 |
Kidney | 1 | 0 | 1 |
Mediastinum | 1 | 0 | 1 |
Prostate | 1 | 0 | 1 |
Total | 34 | 26 | 60 |
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Kudura, K.; Dimitriou, F.; Mihic-Probst, D.; Muehlematter, U.J.; Kutzker, T.; Basler, L.; Förster, R.; Dummer, R.; Mangana, J.; Husmann, L.; et al. Malignancy Rate of Indeterminate Findings on FDG-PET/CT in Cutaneous Melanoma Patients. Diagnostics 2021, 11, 883. https://doi.org/10.3390/diagnostics11050883
Kudura K, Dimitriou F, Mihic-Probst D, Muehlematter UJ, Kutzker T, Basler L, Förster R, Dummer R, Mangana J, Husmann L, et al. Malignancy Rate of Indeterminate Findings on FDG-PET/CT in Cutaneous Melanoma Patients. Diagnostics. 2021; 11(5):883. https://doi.org/10.3390/diagnostics11050883
Chicago/Turabian StyleKudura, Ken, Florentia Dimitriou, Daniela Mihic-Probst, Urs J. Muehlematter, Tim Kutzker, Lucas Basler, Robert Förster, Reinhard Dummer, Joanna Mangana, Lars Husmann, and et al. 2021. "Malignancy Rate of Indeterminate Findings on FDG-PET/CT in Cutaneous Melanoma Patients" Diagnostics 11, no. 5: 883. https://doi.org/10.3390/diagnostics11050883
APA StyleKudura, K., Dimitriou, F., Mihic-Probst, D., Muehlematter, U. J., Kutzker, T., Basler, L., Förster, R., Dummer, R., Mangana, J., Husmann, L., Burger, I. A., & Kreissl, M. C. (2021). Malignancy Rate of Indeterminate Findings on FDG-PET/CT in Cutaneous Melanoma Patients. Diagnostics, 11(5), 883. https://doi.org/10.3390/diagnostics11050883