Ciliary Videomicroscopy: A Long Beat from the European Respiratory Society Guidelines to the Recognition as a Confirmatory Test for Primary Ciliary Dyskinesia
Abstract
:1. Introduction
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- High-speed video analysis, including CBF and CBP analysis, should be used as part of the diagnostic work-up of patients suspected of having PCD (weak recommendation);
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- CBF should not be used without assessment of CBP in diagnosing PCD (strong recommendation);
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- To improve the diagnostic accuracy of DHSV, CBF and CBP assessment should be repeated after air–liquid interface epithelial cell culture (strong recommendation) [5].
2. Update of Literature Concerning Ciliary Videomicroscopy since the 2017 European Respiratory Society Recommendation, Concerning Ciliary Videomicroscopy Sensitivity and Specificity for PCD, and Advances in the Standardization of the Technique
2.1. The Lack of Evidence on DHSV’s Diagnostic Efficiency
2.2. The Lack of Consensus on a Standard Operating Procedure to Perform DHSV
2.3. The Lack of Consensus on the Measured Parameters for Ciliary Beating Evaluation
3. New Applications of Videomicroscopy, Focusing on New Approaches for Automated Ciliary Motion Evaluation
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Bricmont, N.; Alexandru, M.; Louis, B.; Papon, J.-F.; Kempeneers, C. Ciliary Videomicroscopy: A Long Beat from the European Respiratory Society Guidelines to the Recognition as a Confirmatory Test for Primary Ciliary Dyskinesia. Diagnostics 2021, 11, 1700. https://doi.org/10.3390/diagnostics11091700
Bricmont N, Alexandru M, Louis B, Papon J-F, Kempeneers C. Ciliary Videomicroscopy: A Long Beat from the European Respiratory Society Guidelines to the Recognition as a Confirmatory Test for Primary Ciliary Dyskinesia. Diagnostics. 2021; 11(9):1700. https://doi.org/10.3390/diagnostics11091700
Chicago/Turabian StyleBricmont, Noemie, Mihaela Alexandru, Bruno Louis, Jean-François Papon, and Céline Kempeneers. 2021. "Ciliary Videomicroscopy: A Long Beat from the European Respiratory Society Guidelines to the Recognition as a Confirmatory Test for Primary Ciliary Dyskinesia" Diagnostics 11, no. 9: 1700. https://doi.org/10.3390/diagnostics11091700