Circulating Hsa-miR-431-5p as Potential Biomarker for Squamous Cell Vulvar Carcinoma and Its Premalignant Lesions
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. HPV Genotyping
2.3. RNA Isolation from Plasma and RT-qPCR
2.4. Statistical Analyzes
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patients Enrolled (n) | Median Age (Years) (Range) | FIGO | G | hrHPV Status | |
---|---|---|---|---|---|
HSIL | 21 | 57.1 (26.3–83.4) | |||
dVIN | 8 | 50.4 (18.8–79.5) | |||
Primary VSCC | 107 | 72.4 (37.3–94.2) | I n = 56 II n = 3 III n = 30 IV n = 3 N/A n = 6 | G1 n = 32 G2 n = 37 G3 n = 13 N/A n = 16 | negative n = 26 positive n = 44 N/A n = 28 |
Recurrent VSCC | 9 | 74.8 (85.8–72.1) |
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Bujko, M.; Zalewski, K.; Szczyrek, M.; Kowalik, A.; Boresowicz, J.; Długosz, A.; Goryca, K.; Góźdź, S.; Kowalewska, M. Circulating Hsa-miR-431-5p as Potential Biomarker for Squamous Cell Vulvar Carcinoma and Its Premalignant Lesions. Diagnostics 2021, 11, 1706. https://doi.org/10.3390/diagnostics11091706
Bujko M, Zalewski K, Szczyrek M, Kowalik A, Boresowicz J, Długosz A, Goryca K, Góźdź S, Kowalewska M. Circulating Hsa-miR-431-5p as Potential Biomarker for Squamous Cell Vulvar Carcinoma and Its Premalignant Lesions. Diagnostics. 2021; 11(9):1706. https://doi.org/10.3390/diagnostics11091706
Chicago/Turabian StyleBujko, Mateusz, Kamil Zalewski, Martyna Szczyrek, Artur Kowalik, Joanna Boresowicz, Angelika Długosz, Krzysztof Goryca, Stanisław Góźdź, and Magdalena Kowalewska. 2021. "Circulating Hsa-miR-431-5p as Potential Biomarker for Squamous Cell Vulvar Carcinoma and Its Premalignant Lesions" Diagnostics 11, no. 9: 1706. https://doi.org/10.3390/diagnostics11091706
APA StyleBujko, M., Zalewski, K., Szczyrek, M., Kowalik, A., Boresowicz, J., Długosz, A., Goryca, K., Góźdź, S., & Kowalewska, M. (2021). Circulating Hsa-miR-431-5p as Potential Biomarker for Squamous Cell Vulvar Carcinoma and Its Premalignant Lesions. Diagnostics, 11(9), 1706. https://doi.org/10.3390/diagnostics11091706