Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Sources and Search Strategy
2.2. Inclusion and Exclusion Criteria
- full text articles;
- articles reporting PRO after undergoing both COC and CCE or randomized controlled trials (RCT);
- articles in English/Danish/Italian/French/Spanish language.
- non-RCT articles in which patients underwent either COC or CCE alone;
- the following article types: reviews, conference papers, case reports.
2.3. Screening of References
2.4. Data Extraction
2.5. Study Assessment and Risk of Bias
2.6. Statistical Analysis
3. Results
3.1. Search
3.2. Patient Preference
3.3. Adverse Events
3.4. Tolerability
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A
Appendix A.1. PICO
Investigation | Comparator | Outcome |
---|---|---|
Capsule camera* Wireless camera* Wireless camera endoscop* WCE CCE Colon capsule endoscop* PillCam* Pill Cam* Camera pill* Capsule endoscop* Endoscop*, Capsule Wireless Capsule Endoscop* Capsule Endoscop*, Wireless Endoscop*, Wireless Capsule Video Capsule Endoscop* Capsule Endoscop*, Video Capsule Endoscopy, Video Endoscop*, Video Capsule Pan-enteric capsule endoscop* | Colonoscopy(MESH) Colonoscop* Colonoscopic Surgical Procedure* Procedure*, Colonoscopic Surgical Surgical Procedure*, Colonoscopic Surger*, Colonoscopic Surgical Procedure*, Colonoscopic Colonoscopic Surger* Colonoscopes(MESH) Colonoscope* | Patient-related outcome Patient acceptance of health care(MESH) Health Care Utilization Utilization, Health Care Patient Acceptance of Healthcare Healthcare Patient Acceptance* Nonacceptor* of Health Care Care Nonacceptor*, Health Health Care Nonacceptor* Health Care Seeking Behavior Acceptor* of Health Care Care Acceptor*, Health Health Care Acceptor* Health Care Acceptabili* Acceptability of Healthcare Healthcare Acceptabilit* Patient satisfaction(MESH) Patient preference(MESH) Patient Preference*. patient Patient comfort(MESH) Comfort, patient Comfort care Care, comfort Patient Confidence Tolerance Compliance Preference Patient-reported treatment outcome Patient-reported patientreported Self-reported Selfreported Interview* Questionnaire* Adverse event* Minor complication* Major complication* Complication* Adverse effect* Adverse reaction* PROM* |
Appendix A.2. Search Strings
Appendix B
Author, Year | Checklist | Evaluation |
---|---|---|
Alvarez-Urturi, 2017 | STROBE | Medium |
Brechmann, 2016 | STROBE | Medium |
Bruining, 2020 | STROBE | High |
D’Haens, 2015 | STROBE | High |
Eliakim, 2010 | STROBE | High |
Fiorillo, 2020 | STROBE | High |
Groth, 2012 | STROBE | Medium |
Meister, 2013 | STROBE | Medium |
Pilz, 2010 | STROBE | High |
Shi, 2017 | STROBE | High |
Thygesen, 2019 | STROBE | High |
Voska, 2019 | STROBE | High |
Adrian-De-Ganzo, 2015 | RoB | High (low risk of bias) |
Cash, 2020 | RoB | High (low risk of bias) |
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Author—Year | Country | Study Type | PR CCE Preference | PR COC Preference | PR AE | PR Tolerability |
---|---|---|---|---|---|---|
Adrian-De-Ganzo 2015 [18] | Spain | RCT | Yes | Yes | Yes | No |
Alvarez-Urturi 2017 [19] | Spain | OBS | Yes | Yes | Yes | Yes |
Brechmann 2016 [20] | Germany | OBS | Yes | Yes | Yes | No |
Bruining 2020 [21] | USA, Austria, Israel | OBS | Yes | Yes | No | No |
Cash 2020 [22] | USA | RCT | Yes | Yes | Yes | No |
D’Haens 2015 [23] | Netherlands, Belgium | OBS | Yes | No | Yes | Yes |
Eliakim 2010 [24] | Israel | OBS | No | No | Yes | No |
Fiorillo 2020 [25] | France | OBS | No | No | Yes | Yes |
Groth 2012 [26] | Germany | OBS | Yes | Yes | Yes | No |
Meister 2013 [27] | Germany | OBS | No | No | Yes | Yes |
Pilz 2010 [28] | Switzerland | OBS | Yes | Yes | Yes | No |
Shi 2017 [29] | Hong Kong | OBS | Yes | No | Yes | Yes |
Thygesen 2019 [11] | Denmark | OBS | No | No | Yes | Yes |
Voska 2019 [30] | Czech Republic | OBS | Yes | Yes | Yes | No |
Colon Capsule Endoscopy | ||||
Variable | Coefficient | Lower CI 95% | Upper CI 95% | p-value |
Year published (continuous) | −0.003 | −0.081 | 0.074 | 0.936 |
Year published (categorical, before vs. after 2016) | −0.058 | −0.517 | 0.401 | 0.804 |
Sample size (continuous) | −0.002 | −0.004 | 0.001 | 0.319 |
Study type (RCT vs. OBS) | 0.116 | −0.433 | 0.665 | 0.679 |
Centers (multi vs. single) | −0.078 | −0.554 | 0.397 | 0.746 |
Modality of data collection (oral vs. questionnaire) | −0.209 | −0.660 | 0.241 | 0.362 |
Age mean (continuous) | −0.023 | −0.046 | <0.001 | 0.054 |
Male percentage (continuous) | −0.013 | −0.042 | 0.015 | 0.366 |
Completion rate (continuous) | −0.003 | −0.024 | 0.018 | 0.772 |
Completion rate (categorical) | −0.018 | −0.481 | 0.444 | 0.938 |
Capsule type (CCE2 vs. CCE1) | 0.190 | −0.363 | 0.742 | 0.501 |
Capsule type (PillCam Crohn® vs. CCE1) | 0.142 | −0.709 | 0.994 | 0.743 |
Patient group (symptomatic vs. screening) | −0.045 | −0.856 | 0.766 | 0.913 |
Patient group (chronic illness vs. screening) | 0.301 | −0.163 | 0.764 | 0.204 |
Evaluation of study (STROBE/Cochrane) | 0.040 | −0.520 | 0.601 | 0.887 |
Colonoscopy | ||||
Variable | Coefficient | Lower CI 95% | Upper CI 95% | p-value |
Year published (continuous) | 0.010 | −0.063 | 0.083 | 0.797 |
Year published (categorical, before vs. after 2016) | 0.063 | −0.487 | 0.612 | 0.823 |
Sample size (continuous) | 0.002 | −0.002 | 0.005 | 0.370 |
Study type (RCT vs. OBS) | −0.345 | −0.879 | 0.189 | 0.206 |
Centers (multi vs. single) | −0.017 | −0.609 | 0.575 | 0.955 |
Modality of data collection (oral vs. questionnaire) | −0.024 | −0.613 | 0.565 | 0.937 |
Age mean (continuous) | 0.022 | −0.009 | 0.053 | 0.155 |
Male percentage (continuous) | 0.004 | −0.024 | 0.032 | 0.772 |
Completion rate (continuous) | 0.057 | −0.035 | 0.150 | 0.223 |
Completion rate (categorical) | 0.006 | −0.632 | 0.644 | 0.985 |
Patient group (symptomatic vs. screening) | −0.267 | −1.103 | 0.568 | 0.531 |
Patient group (chronic illness vs. screening) | −0.345 | −1.033 | 0.343 | 0.326 |
Evaluation of studies (STROBE/Cochrane) | 0.036 | −0.533 | 0.606 | 0.900 |
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Share and Cite
Deding, U.; Cortegoso Valdivia, P.; Koulaouzidis, A.; Baatrup, G.; Toth, E.; Spada, C.; Fernández-Urién, I.; Pennazio, M.; Bjørsum-Meyer, T. Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis. Diagnostics 2021, 11, 1730. https://doi.org/10.3390/diagnostics11091730
Deding U, Cortegoso Valdivia P, Koulaouzidis A, Baatrup G, Toth E, Spada C, Fernández-Urién I, Pennazio M, Bjørsum-Meyer T. Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis. Diagnostics. 2021; 11(9):1730. https://doi.org/10.3390/diagnostics11091730
Chicago/Turabian StyleDeding, Ulrik, Pablo Cortegoso Valdivia, Anastasios Koulaouzidis, Gunnar Baatrup, Ervin Toth, Cristiano Spada, Ignacio Fernández-Urién, Marco Pennazio, and Thomas Bjørsum-Meyer. 2021. "Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis" Diagnostics 11, no. 9: 1730. https://doi.org/10.3390/diagnostics11091730