Inter/Intra-Observer Agreement in Video-Capsule Endoscopy: Are We Getting It All Wrong? A Systematic Review and Meta-Analysis
, Ulrik Deding 2,3,†, Thomas Bjørsum-Meyer 2,3, Gunnar Baatrup 2,3, Ignacio Fernández-Urién 4, Xavier Dray 5, Pedro Boal-Carvalho 6, Pierre Ellul 7, Ervin Toth 8, Emanuele Rondonotti 9, Lasse Kaalby 2,3, Marco Pennazio 10 and Anastasios Koulaouzidis 2,11,12,13
on behalf of the International CApsule endoscopy REsearch (I-CARE) Group
Round 1
Reviewer 1 Report
In the present systematic review with meta-analysis about reader’s agreement in videocapsule endoscopy (VCE), Cortegoso Valdivia et al showed that most of studies reported a low inter- and intra-observer agreement and high heterogeneity among studies.
Some types of small bowel lesions are more prone to misdiagnosis. In this meta-analysis, several types of indications have been pooled and, therefore, this may explain the very high heterogeneity. Therefore I suggest, if possible, to perform sub-analyses by aggregating data/studies according to the different indication/finding of VCE.
Please update literature search (December 2021 is quite outdated).
Author Response
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Author Response File: 
Author Response.doc
Reviewer 2 Report
Well written study and meta-analysis. I do not have major comments, just two points that need clarification by the authors
1) What does the I-CARE group stand for? I know that there is an i-care study organized by GETAID for IBD patients, but I do not think this is the same group. Please clarify
2) Most of the readers do not know what inter and intra-obsever agreemnt mean. I think that the authors need to clarify these terms better in the Introduction or Methods and also distinguish better the two terms in the Discussion
Author Response
Please see the attachment
Author Response File: Author Response.doc
Round 2
Reviewer 1 Report
Answers were fine
