Next Article in Journal
Characteristic of Concurrent Uterine Lipoleiomyoma and Hemangioma by Algorithm of Candidate Biomarkers for Uterine Mesenchymal Tumor
Next Article in Special Issue
N6-methyladenosine Modification of Noncoding RNAs: Mechanisms and Clinical Applications in Cancer
Previous Article in Journal
Associations between Bone Mineral Density and Longitudinal Changes of Vertebral Bone Marrow and Paraspinal Muscle Composition Assessed Using MR-Based Proton Density Fat Fraction and T2* Maps in Patients with and without Osteoporosis
Previous Article in Special Issue
Increased Expression of Pyroptosis in Leukocytes of Patients with Kawasaki Disease
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Diagnostics
Volume 12
Issue 10
10.3390/diagnostics12102469
Review Report
diagnostics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

The Diagnostic and Therapeutic Role of Circular RNA HIPK3 in Human Diseases

Diagnostics 2022, 12(10), 2469; https://doi.org/10.3390/diagnostics12102469
by Yanfei Feng 1,†, Zitong Yang 2,†, Bodong Lv 3,* and Xin Xu 4,*
Reviewer 1:
Dane Krtinic
Reviewer 2:
Md-Zahid Akhter
Reviewer 3:
Xavier Sastre-Garau
Diagnostics 2022, 12(10), 2469; https://doi.org/10.3390/diagnostics12102469
Submission received: 14 September 2022 / Revised: 5 October 2022 / Accepted: 9 October 2022 / Published: 12 October 2022
(This article belongs to the Special Issue The Diagnostic and Therapeutic Value of RNAs in Human Diseases)

Round 1

Reviewer 1 Report

Well done!

Author Response

Thank you very much for your comment!

Reviewer 2 Report

Feng etal., attempts to explore the diagnostic and pathological role of CirRNA HIPK3 in human diseases.

My concerns are as below.

1.       English language and grammatical errors are prevalent throughout the manuscript., such as in line 51 …activating sone other miRNAs … some other”.

2.       The authors described the biogenesis of circHIPK3. However how it’s transcription is regulated is missing.

3.       In this review, circHIPK3 s upregulated in most of the cancer. Can it be considered as “tumor marker”. Please discuss this point in the review.

4.       The review lacks the future perspective in terms of therapeutic role of circHIPK3.

Author Response

Thank you very much for your comments! We have made some improvements accordingly. Please see the revised manuscript.

Author Response File: Author Response.pdf

Reviewer 3 Report

The paper by Yanfei Feng et al., entitled The Diagnostic and Therapeutic Role of Circular RNA HIPK3 in Human Diseases is a large review of the works that reported a potential role of HIPK3 in the pathogenesis and/or the course of many a tumor and non-tumor diseases.

The paper is well documented, well written, and deserves to be published. The reader is somewhat bewildered considering that the same molecular entity could be implied in so numerous and diverse pathologies. A hierarchy of the works according to the strength of the association between HIPK3 expression and disease might be helpful to reduce this apparent pleomorphic impact. Of note, the promotion of cell proliferation is provided as the most frequent Relevant Cell Biology factor (table 1). Might it be the common mechanism underlying the highly common involvement of HIPK3 in so various diseases? A comment of the authors on this point would be of interest.

Author Response

Thank you very much for your comments! We have made some improvements accordingly. Please see the revised manuscript.

Author Response File: Author Response.pdf

Back to TopTop