Correlations between Contrast-Enhanced Ultrasound Imaging and Histopathological Results in Salivary Gland Lesions
Abstract
:1. Introduction
2. Materials and Methods
2.1. Image Acquisition and Processing
2.2. Image Analysis
2.3. Statistical Analysis
Multivariate Analysis
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Aghaghazvini, L.; Salahshour, F.; Yazdani, N.; Sharifian, H.; Kooraki, S.; Pakravan, M.; Shakiba, M. Dynamic contrast-enhanced MRI for differentiation of major salivary glands neoplasms, a 3-T MRI study. Dentomaxillofacial Radiol. 2015, 44, 20140166. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Mikaszewski, B.; Markiet, K.; Smugała, A.; Stodulski, D.; Szurowska, E.; Stankiewicz, C. Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging—An Alternative to Fine Needle Biopsy or Only an Adjunct Test in Preoperative Differential Diagnostics of Malignant and Benign Parotid Tumors? J. Oral Maxillofac. Surg. 2017, 75, 2248–2253. [Google Scholar] [CrossRef] [PubMed]
- Hamour, A.F.; O’Connell, D.; Biron, V.L.; Allegretto, M.; Seemann, R.; Harris, J.R.; Seikaly, H.; Côté, D.W.J. Clinical diagnostic utility of ultrasound-guided fine needle aspiration biopsy in parotid masses. Ear Nose Throat J. 2021, 1–5. [Google Scholar] [CrossRef] [PubMed]
- Klotz, L.v.; Gürkov, R.; Eichhorn, M.E.; Siedek, V.; Krause, E.; Jauch, K.W.; Reiser, M.F.; Clevert, D.A. Perfusion characteristics of parotid gland tumors evaluated bycontrast-enhanced ultrasound. Eur. J. Radiol. 2013, 82, 2227–2232. [Google Scholar] [CrossRef] [PubMed]
- Strieth, S.; Siedek, V.; Rytvina, M.; Gürkov, R.; Berghaus, A.; Clevert, D.A. Dynamic contrast-enhanced ultrasound for differential diagnosis of submandibular gland disease. Eur. Arch. Oto-Rhino-Laryngol. 2014, 271, 163–169. [Google Scholar] [CrossRef] [PubMed]
- Guiban, O.; Rubini, A.; Fresilli, D.; Lucarelli, G.T.; Ralli, M.; Cassoni, A.; Bezzi, M.; Radzina, M.; Greco, A.; de Vincentiis, M.; et al. Preoperative Multiparametric Ultrasound and Fine Needle Aspiration Cytology evaluation of parotid gland tumors: Which is the best technique? Med. Ultrason. 2021, 23, 402–409. [Google Scholar] [CrossRef] [PubMed]
- Saito, D.; Shiga, K.; Katagiri, K.; Oikawa, S.I.; Ikeda, A.; Tsuchida, K.; Miyaguchi, J.; Kusaka, T.; Kuroda, H.; Takahashi, F. Contrast-enhanced ultrasonography for the differential diagnosis of pleomorphic adenomas and Warthin tumors in salivary glands. Laryngoscope Investig. Otolaryngol. 2021, 6, 425–431. [Google Scholar] [CrossRef] [PubMed]
- Stoia, S.; Băciuț, G.; Lenghel, M.; Badea, R.; Băciuț, M.; Bran, S.; Dinu, C. Ultrasonography techniques in the preoperative diagnosis of parotid gland tumors—An updated review of the literature. Med. Ultrason. 2021, 23, 194–202. [Google Scholar] [CrossRef] [PubMed]
- Bhatia, K.S.S.; Dai, Y.-L. Routine and Advanced Ultrasound of Major Salivary Glands. Neuroimaging Clin. N. Am. 2018, 28, 273–293. [Google Scholar] [CrossRef] [PubMed]
- Dietrich, C.F.; Averkiou, M.; Nielsen, M.B.; Barr, R.G.; Burns, P.N.; Calliada, F.; Cantisani, V.; Choi, B.; Chammas, M.C.; Clevert, D.A.; et al. How to perform Contrast-Enhanced Ultrasound (CEUS). Ultrasound Int. Open 2018, 4, E2–E15. [Google Scholar] [CrossRef] [PubMed]
- Claudon, M.; Cosgrove, D.; Albrecht, T.; Bolondi, L.; Bosio, M.; Calliada, F.; Correas, J.M.; Darge, K.; Dietrich, C.; D’Onofrio, M.; et al. Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS)—Update 2008. Ultraschall der Med. Eur. J. Ultrasound 2008, 29, 28–44. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- David, E.; Cantisani, V.; De Vincentiis, M.; Sidhu, P.; Greco, A.; Tombolini, M.; Drudi, F.M.; Messineo, D.; Gigli, S.; Rubini, A.; et al. Contrast-enhanced ultrasound in the evaluation of parotid gland lesions: An update of the literature. Ultrasound 2016, 24, 104–110. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Westwood, M.; Joore, M.; Grutters, J.; Redekop, K.; Armstrong, N.; Lee, K.; Gloy, V.; Raatz, H.; Misso, K.; Severens, J.; et al. Contrast-enhanced ultrasound using SonoVue® (sulphur hexafluoride microbubbles) compared with contrast- enhanced computed tomography and contrast-enhanced magnetic resonance imaging for the characterisation of focal liver lesions and detection of liver metastases: A systematic review and cost-effectiveness analysis. Health Technol. Assess. 2013, 17, 7–243. [Google Scholar] [CrossRef] [Green Version]
- Young, A.; Okuyemi, O.T. Malignant Salivary Gland Tumors. [Updated February 16 2022]; StatPearls Publishing: St. Petersburg, FL, USA, January 2022. Available online: https://www.ncbi.nlm.nih.gov/books/NBK563022/ (accessed on 24 July 2022).
- Zhan, K.Y.; Khaja, S.F.; Flack, A.B.; Day, T.A. Benign Parotid Tumors. Otolaryngol. Clin. N. Am. 2016, 49, 327–342. [Google Scholar] [CrossRef] [PubMed]
Total Numer | Malignant/With Malignant Potential | Benign | p | OR (95% CI) | ||
---|---|---|---|---|---|---|
Sex | Male | 28 | 9 (34.62%) | 19 (51.35%) | 0.2 * | 0.5 (0.178; 1.41) |
Female | 35 | 17 (65.38%) | 18 (48.65%) | |||
Shape | Round | 16 | 9 (34.62%) | 7 (18.92%) | 0.391 *** | N/A |
Multiple curved | 43 | 16 (61.54%) | 27 (72.97%) | |||
Blurred | 4 | 1 (3.85%) | 3 (8.11%) | |||
Pattern of contrast enhancement | Strong homogeneous | 3 | 1 (3.85%) | 2 (5.41%) | 0.017 *** | N/A |
Weak homogeneous | 3 | 1 (3.85%) | 2 (5.41%) | |||
Strong heterogeneous | 36 | 10 (38.46%) | 26 (70.27%) | |||
Weak heterogeneous | 21 | 14 (53.85%) | 7 (18.92%) | |||
Echogenicity | Hypoechogenic | 62 | 26 (100%) | 36 (97.30%) | 1 ** | N/A |
Hyperechogenic | 1 | 0 | 1 (2.70%) |
Model | AUC | Youden’s Index | Cut-Off Value | Sensitivity | Specificity | ACC | PPV | NPV | LR |
---|---|---|---|---|---|---|---|---|---|
1 | AUC 0.770 (SE 0.062) | 0.503 | 0.547 | 69.2% | 81.1% | 76.2% | 72.0% | 78.9% | 3.66 |
2 | AUC 0.683 (SE 0.0687) | 0.379 | 0.407 | 73.1% | 64.9% | 68.3% | 59.4% | 77.4% | 2.08 |
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Krupa, K.; Wieczorek, P.; Scrinscaia, O.; Puzio, A.; Kozłowski, Z.; Pietruszewska, W.; Stefańczyk, L. Correlations between Contrast-Enhanced Ultrasound Imaging and Histopathological Results in Salivary Gland Lesions. Diagnostics 2022, 12, 2636. https://doi.org/10.3390/diagnostics12112636
Krupa K, Wieczorek P, Scrinscaia O, Puzio A, Kozłowski Z, Pietruszewska W, Stefańczyk L. Correlations between Contrast-Enhanced Ultrasound Imaging and Histopathological Results in Salivary Gland Lesions. Diagnostics. 2022; 12(11):2636. https://doi.org/10.3390/diagnostics12112636
Chicago/Turabian StyleKrupa, Karolina, Patryk Wieczorek, Olga Scrinscaia, Anna Puzio, Zbigniew Kozłowski, Wioletta Pietruszewska, and Ludomir Stefańczyk. 2022. "Correlations between Contrast-Enhanced Ultrasound Imaging and Histopathological Results in Salivary Gland Lesions" Diagnostics 12, no. 11: 2636. https://doi.org/10.3390/diagnostics12112636