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Diagnostics
Volume 12
Issue 11
10.3390/diagnostics12112663
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Case Report
Peer-Review Record

Tuberculosis Epididymo-Orchitis Mimicking Malignancy Resulting from Intravesical Bacillus Calmette–Guérin Immunotherapy for Bladder Cancer: A Case Report of a Rare Complication

Diagnostics 2022, 12(11), 2663; https://doi.org/10.3390/diagnostics12112663
by Liang-Wei Chiu 1, Li-Hsien Tsai 1, Po-Fan Hsieh 1,2, Wen-Chi Chen 1,3 and Chao-Hsiang Chang 1,*
Reviewer 1:
Theo M. De Reijke
Diagnostics 2022, 12(11), 2663; https://doi.org/10.3390/diagnostics12112663
Submission received: 10 October 2022 / Revised: 24 October 2022 / Accepted: 29 October 2022 / Published: 2 November 2022
(This article belongs to the Special Issue Detection, Diagnosis, and Management of Bladder Cancer—Integration of Non-invasive Diagnostics into Medical Decision Making)

Round 1

Reviewer 1 Report

Complications following intravesical BCG treatment should be known and it is important to realize that these complications can occur long time following BCG instillations.

Initially, the patient was treated with antibiotics although there were no signs of infection especially with orchitis the patient should have fever, therefore, a delay in diagnosis was made. 

Thus. this should be changed in the recommendations, there should not be a empiric AB treatment.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Liang Wei-Chiu et al. described a case of tuberculosis epididymo-orchitis mimicking tumor as an effect of intravesical BCG therapy for BCa.

Generally the manuscript is well organized and written, following the rules for case report.

However, its substantive value in the category of a scientific report is doubtful and, in my opinion, it does not bring anything innovative. Testicular tumors quite often mimic the symptoms of epididymitis. On the other hand, testicular tumor rarely occurs in elderly patients, and the fact that epididymitis may be one of the symptoms of urogenital tuberculosis is well known.

An interesting fact in this case is the combined therapy - BCG + checkpoint inhibitor - analysis of this issue could influence the "attractiveness and specificity" of the presented case. This thread is not mentioned by the authors in the article - especially in the discussion.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

Authors adressed comments.

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