Sex-Specific Differences in Cardiovascular Risk, Risk Factors and Risk Management in the Peripheral Arterial Disease Population
Abstract
1. Introduction
1.1. Peripheral Arterial Disease and Cardiovascular Risk—Cardiology’s Poor Cousin
1.2. Women with Peripheral Vascular Disease—A Greater Cardiovascular Risk?
1.3. Traditional Cardiovascular Risk Factors
1.4. Non-Traditional Cardiovascular Risk Factors
1.5. Sex-Specific Risk Factors
1.6. Sex-Predominant Risk Factors
1.7. Intersectionality: Gender, Race and Sociodemographic Factors
1.8. Sex-Specific Differences in Traditional Cardiovascular Risk Management
2. Discussion
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
- Woodward, M. Cardiovascular Disease and the Female Disadvantage. Int. J. Environ. Res. Public Health 2019, 16, 1165. [Google Scholar] [CrossRef] [PubMed]
- Mozaffarian, D.; Benjamin, E.J.; Go, A.S.; Arnett, D.K.; Blaha, M.J.; Cushman, M.; Das, S.R.; de Ferranti, S.; Després, J.-P.; Fullerton, H.J.; et al. AHA Statistical Update Heart Disease and Stroke Statistics—2016 Update A Report From the American Heart Association Writing Group Members. Circulation 2016, 133, e599. [Google Scholar] [CrossRef]
- Leening, M.J.G.; Ferket, B.; Steyerberg, E.W.; Kavousi, M.; Deckers, J.W.; Nieboer, D.; Heeringa, J.; Portegies, M.L.P.; Hofman, A.; Ikram, M.A.; et al. Sex differences in lifetime risk and first manifestation of cardiovascular disease: Prospective population based cohort study. BMJ 2014, 349, g5992. [Google Scholar] [CrossRef] [PubMed]
- Hoel, A.W.; Kayssi, A.; Brahmanandam, S.; Belkin, M.; Conte, M.S.; Nguyen, L.L. Under-representation of Women and Ethnic Minorities in Vascualr Surgery Randomized Controlled Trials. J. Vasc. Surg. 2009, 50, 349–354. [Google Scholar] [CrossRef]
- Gulati, M. Improving the Cardiovascular Health of Women in the Nation. Circulation 2017, 135, 495–498. [Google Scholar] [CrossRef]
- Jin, X.; Chandramouli, C.; Allocco, B.; Gong, E.; Lam, C.S.; Yan, L.L. Women’s Participation in Cardiovascular Clinical Trials From 2010 to 2017. Circulation 2020, 141, 540–548. [Google Scholar] [CrossRef]
- A Alabas, O.; Gale, C.P.; Hall, M.; Rutherford, M.J.; Szummer, K.; Lawesson, S.S.; Alfredsson, J.; Lindahl, B.; Jernberg, T. Sex Differences in Treatments, Relative Survival, and Excess Mortality Following Acute Myocardial Infarction: National Cohort Study Using the SWEDEHEART Registry. J. Am. Heart Assoc. 2017, 6, e007123. [Google Scholar] [CrossRef]
- Hirsch, A.T.; Allison, M.A.; Gomes, A.S.; Corriere, M.A.; Duval, S.; Ershow, A.G.; Hiatt, W.R.; Karas, R.H.; Lovell, M.B.; McDermott, M.M.; et al. A call to action: Women and peripheral artery disease: A scientific statement from the american heart association. Circulation 2012, 125, 1449–1472. [Google Scholar] [CrossRef]
- Mahoney, E.M.; Wang, K.; Cohen, D.J.; Hirsch, A.T.; Alberts, M.J.; Eagle, K.; Mosse, F.; Jackson, J.D.; Steg, P.G.; Bhatt, D.L. One-Year Costs in Patients With a History of or at Risk for Atherothrombosis in the United States. Circ. Cardiovasc. Qual. Outcomes 2008, 1, 38–45. [Google Scholar] [CrossRef]
- Hirsch, A.T.; Hartman, L.; Town, R.J.; Virnig, B.A. National health care costs of peripheral arterial disease in the Medicare population. Vasc. Med. 2008, 13, 209–215. [Google Scholar] [CrossRef]
- Fowkes, F.G.R.; Housley, E.; Cawood, E.H.H.; Macintyre, C.C.A.; Ruckley, C.V.; Prescott, R.J. Edinburgh Artery Study: Prevalence of Asymptomatic and Symptomatic Peripheral Arterial Disease in the General Population. Int. J. Epidemiol. 1991, 20, 384–392. [Google Scholar] [CrossRef] [PubMed]
- Cea-Soriano, L.; Fowkes, F.G.R.; Johansson, S.; Allum, A.M.; Rodriguez, L.A.G. Time trends in peripheral artery disease incidence, prevalence and secondary preventive therapy: A cohort study in The Health Improvement Network in the UK. BMJ Open 2018, 8, e018184. [Google Scholar] [CrossRef] [PubMed]
- Fowkes, F.G.R.; Rudan, D.; Rudan, I.; Aboyans, V.; Denenberg, J.O.; McDermott, M.M.; Norman, P.E.; Sampson, U.K.A.; Williams, L.J.; Mensah, G.A.; et al. Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: A systematic review and analysis. Lancet 2013, 382, 1329–1340. [Google Scholar] [CrossRef]
- Criqui, M.H.; Aboyans, V. Epidemiology of peripheral artery disease. Circ. Res. 2015, 116, 1509–1526. [Google Scholar] [CrossRef] [PubMed]
- Ankle Brachial Index Collaboration. Ankle Brachial Index Combined with Framingham RIsk Score to Predict Cardiovascular Events and Mortality: A Meta-analysis. JAMA 2010, 300, 197–208. [Google Scholar] [CrossRef]
- Steg, P.G.; Bhatt, D.L.; Wilson, P.W.F.; D’Agostino, R.; Ohman, E.M.; Röther, J.; Liau, C.-S.; Hirsch, A.T.; Mas, J.-L.; Ikeda, Y.; et al. One-year cardiovascular event rates in outpatients with atherothrombosis. JAMA 2007, 297, 1197–1206. [Google Scholar] [CrossRef]
- Gasse, C.; Jacobsen, J.; Larsen, A.; Schmidt, E.B.; Johannesen, N.; Videbæk, J.; Sørensen, H.T.; Johnsen, S. Secondary Medical Prevention among Danish Patients Hospitalised with Either Peripheral Arterial Disease or Myocardial Infarction. Eur. J. Vasc. Endovasc. Surg. 2008, 35, 51–58. [Google Scholar] [CrossRef]
- Carcel, C.; Harris, K.; Peters, S.A.; Sandset, E.C.; Balicki, G.; Bushnell, C.D.; Howard, V.J.; Reeves, M.J.; Anderson, C.S.; Kelly, P.J.; et al. Representation of Women in Stroke Clinical Trials. Neurology 2021, 97, e1768–e1774. [Google Scholar] [CrossRef]
- Higgins, J.P.; Higgins, J.A. Epidemiology of peripheral arterial disease in women. J. Epidemiol. 2003, 13, 1–14. [Google Scholar] [CrossRef]
- Hussain, M.A.; Lindsay, T.F.; Mamdani, M.; Wang, X.; Verma, S.; Al-Omran, M. Sex differences in the outcomes of peripheral arterial disease: A population-based cohort study. CMAJ Open 2016, 4, E124–E131. [Google Scholar] [CrossRef]
- Cherr, G.S.; Zimmerman, P.M.; Wang, J.; Dosluoglu, H.H. Patients with Depression are at Increased Risk for Secondary Cardiovascular Events after Lower Extremity Revascularization. J. Gen. Intern. Med. 2008, 23, 629–634. [Google Scholar] [CrossRef] [PubMed]
- McDermott, M.M.; Greenland, P.; Liu, K.; Criqui, M.H.; Guralnik, J.M.; Celic, L.; Chan, C. Sex Differences in Peripheral Arterial Disease: Leg Symptoms and Physical Functioning. J. Am. Geriatr. Soc. 2003, 51, 222–228. [Google Scholar] [CrossRef] [PubMed]
- Collins, T.C.; Suarez-Almazor, M.; Bush, R.L.; Petersen, N.J. Gender and Peripheral Arterial Disease. J. Am. Board Fam. Med. 2006, 19, 132–140. [Google Scholar] [CrossRef] [PubMed][Green Version]
- Ortmann, J.; Nüesch, E.; Traupe, T.; Diehm, N.; Baumgartner, I. Gender is an independent risk factor for distribution pattern and lesion morphology in chronic critical limb ischemia. J. Vasc. Surg. 2012, 55, 98–104. [Google Scholar] [CrossRef]
- Jackson, E.A.; Munir, K.; Schreiber, T.; Rubin, J.R.; Cuff, R.; Gallagher, K.A.; Henke, P.K.; Gurm, H.; Grossman, P.M. Impact of Sex on Morbidity and Mortality Rates After Lower Extremity Interventions for Peripheral Arterial Disease. J. Am. Coll. Cardiol. 2014, 63, 2525–2530. [Google Scholar] [CrossRef]
- Behrendt, C.-A.; Bischoff, M.S.; Schwaneberg, T.; Hohnhold, R.; Diener, H.; Debus, E.S.; Rieß, H.C. Population Based Analysis of Gender Disparities in 23,715 Percutaneous Endovascular Revascularisations in the Metropolitan Area of Hamburg. Eur. J. Vasc. Endovasc. Surg. 2019, 57, 658–665. [Google Scholar] [CrossRef]
- McGinigle, K.L.; Browder, S.E.; Strassle, P.D.; Shalhub, S.; Harris, L.M.; Minc, S.D. Sex-related disparities in intervention rates and type of intervention in patients with aortic and peripheral arterial diseases in the National Inpatient Sample Database. J. Vasc. Surg. 2020, 73, 2081–2089.e7. [Google Scholar] [CrossRef]
- Hultgren, R.; Olofsson, P.; Wahlberg, E. Sex-related differences in outcome after vascular interventions for lower limb ischemia. J. Vasc. Surg. 2002, 35, 510–516. [Google Scholar] [CrossRef]
- Vouyouka, A.G.; Egorova, N.N.; Salloum, A.; Kleinman, L.; Marin, M.; Faries, P.L.; Moscowitz, A. Lessons learned from the analysis of gender effect on risk factors and procedural outcomes of lower extremity arterial disease. J. Vasc. Surg. 2010, 52, 1196–1202. [Google Scholar] [CrossRef]
- Wang, J.; He, Y.; Shu, C.; Zhao, J.; Dubois, L. The effect of gender on outcomes after lower extremity revascularization. J. Vasc. Surg. 2017, 65, 889–906.e4. [Google Scholar] [CrossRef]
- Lancaster, R.; Conrad, M.; Patel, V.; Cambria, R.; LaMuraglia, G. Predictors of Early Graft Failure After Infrainguinal Bypass Surgery: A Risk-adjusted Analysis from the NSQIP. Eur. J. Vasc. Endovasc. Surg. 2012, 43, 549–555. [Google Scholar] [CrossRef]
- Nguyen, L.L.; Brahmanandam, S.; Bandyk, D.F.; Belkin, M.; Clowes, A.W.; Moneta, G.L.; Conte, M.S. Female gender and oral anticoagulants are associated with wound complications in lower extremity vein bypass: An analysis of 1404 operations for critical limb ischemia. J. Vasc. Surg. 2007, 46, 1191–1197.e1. [Google Scholar] [CrossRef]
- Hedayati, N.; Brunson, A.; Li, C.-S.; Baker, A.C.; Pevec, W.C.; White, R.H.; Romano, P.S. Do Women Have Worse Amputation-Free Survival Than Men Following Endovascular Procedures for Peripheral Arterial Disease? An Evaluation of the California State-Wide Database. Vasc. Endovasc. Surg. 2015, 49, 166–174. [Google Scholar] [CrossRef]
- Selvin, E.; Erlinger, T.P. Prevalence of and Risk Factors for Peripheral Arterial Disease in the United States. Circulation 2004, 110, 738–743. [Google Scholar] [CrossRef]
- Hiratzka, L.; Bakris, G.; Beckman, J.; Bersin, R.; Carr, V.; Casey, D.; Eagle, K.A.; Hermann, L.K.; Isselbacher, E.M.; Kazerooni, E.A.; et al. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disease: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2010, 121, e266–e369. [Google Scholar] [CrossRef]
- Kannel, W.B.; McGee, D.L. Update on Some Epidemiologic Features of Intermittent Claudication: The Framingham Study. J. Am. Geriatr. Soc. 1985, 33, 13–18. [Google Scholar] [CrossRef]
- Neal, B.; MacMahon, S.; Chapman, N.; Blood Pressure Lowering Treatment Trialists’ Collaboration. Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: Results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists’ Collaboration. Lancet 2000, 356, 1955–1964. [Google Scholar]
- Gueyffier, F.; Boutitie, F.; Boissel, J.-P.; Pocock, S.; Coope, J.; Cutler, J.; Ekbom, T.; Fagard, R.; Friedman, L.; Perry, M.; et al. Effect of Antihypertensive Drug Treatment on Cardiovascular Outcomes in Women and Men. Ann. Intern. Med. 1997, 126, 761–767. [Google Scholar] [CrossRef]
- Ji, H.; Niiranen, T.J.; Rader, F.; Henglin, M.; Kim, A.; Ebinger, J.E.; Claggett, B.; Merz, C.N.B.; Cheng, S. Sex Differences in Blood Pressure Associations With Cardiovascular Outcomes. Circulation 2021, 143, 761–763. [Google Scholar] [CrossRef]
- Fremantle, T.; Study, D. Peripheral Arterial Disease and Risk of Cardiac Death in Type 2 Diabetes The Fremantle Diabetes Study. Diabetes Care 2006, 29, 575–580. [Google Scholar]
- Di Giovanni, P.; Scampoli, P.; Meo, F.; Cedrone, F.; D’Addezio, M.; Di Martino, G.; Valente, A.; Romano, F.; Staniscia, T. The impact of gender on diabetes-related lower extremity amputations: An Italian regional analysis on trends and predictors. Foot Ankle Surg. 2021, 27, 25–29. [Google Scholar] [CrossRef] [PubMed]
- Tang, Z.-Q.; Chen, H.-L.; Zhao, F.-F. Gender Differences of Lower Extremity Amputation Risk in Patients With Diabetic Foot. Int. J. Low. Extrem. Wounds 2014, 13, 197–204. [Google Scholar] [CrossRef] [PubMed]
- Huxley, R.R.; Peters, S.A.E.; Mishra, G.D.; Woodward, M. Risk of all-cause mortality and vascular events in women versus men with type 1 diabetes: A systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2015, 3, 198–206. [Google Scholar] [CrossRef]
- Peters, S.; Huxley, R.R.; Woodward, M. Diabetes as risk factor for incident coronary heart disease in women compared with men: A systematic review and meta-analysis of 64 cohorts including 858,507 individuals and 28,203 coronary events. Diabetologia 2014, 57, 1542–1551. [Google Scholar] [CrossRef] [PubMed]
- Faulkner, J.L.; Kennard, S.; Huby, A.-C.; Antonova, G.; Lu, Q.; Jaffe, I.Z.; Patel, V.S.; Fulton, D.J.R.; de Chantemèle, E.J.B. Progesterone predisposes females to obesity-associated leptin-mediated endothelial dysfunction via upregulating endothelial MR (mineralocorticoid receptor) expression. Hypertension 2019, 74, 678–686. [Google Scholar] [CrossRef] [PubMed]
- De Jong, M.; Vos, R.C.; De Ritter, R.; Van Der Kallen, C.J.; Sep, S.J.; Woodward, M.; Da Stehouwer, C.; Bots, M.L.; Peters, S.A. Sex differences in cardiovascular risk management for people with diabetes in primary care: A cross-sectional study. BJGP Open 2019, 3. [Google Scholar] [CrossRef]
- Tseng, C.-L.; Sambamoorthi, U.; Rajan, M.; Tiwari, A.; Frayne, S.; Findley, P.; Pogach, L. Are there gender differences in diabetes care among elderly medicare enrolled veterans? J. Gen. Intern. Med. 2006, 21, S47–S53. [Google Scholar] [CrossRef]
- Gardner, A.W.; Parker, D.E.; Montgomery, P.S.; Blevins, S.M. Diabetic women are poor responders to exercise rehabilitation in the treatment of claudication. J. Vasc. Surg. 2013, 59, 1036–1043. [Google Scholar] [CrossRef]
- O’Hare, A.M.; Glidden, D.; Fox, C.S.; Hsu, C.-Y. High Prevalence of Peripheral Arterial Disease in Persons With Renal Insufficiency. Circulation 2004, 109, 320–323. [Google Scholar] [CrossRef]
- Wang, G.J.; Shaw, P.A.; Townsend, R.R.; Anderson, A.H.; Xie, D.; Wang, X.; Nessel, L.C.; Mohler, E.R.; Sozio, S.M.; Jaar, B.G.; et al. Sex Differences in the Incidence of Peripheral Artery Disease in the Chronic Renal Insufficiency Cohort. Circ. Cardiovasc. Qual. Outcomes 2016, 9, S86–S93. [Google Scholar] [CrossRef]
- Thomas, D. Risque cardiovasculaire du tabagisme selon le genre. La Presse Med. 2017, 46, 681–687. [Google Scholar] [CrossRef] [PubMed]
- Huxley, R.R.; Woodward, M. Cigarette smoking as a risk factor for coronary heart disease in women compared with men: A systematic review and meta-analysis of prospective cohort studies. Lancet 2011, 378, 1297–1305. [Google Scholar] [CrossRef]
- Smith, P.H.; Kasza, K.A.; Hyland, A.; Fong, G.T.; Borland, R.; Brady, K.; Carpenter, M.J.; Hartwell, K.; Cummings, K.M.; McKee, S.A. Gender Differences in Medication Use and Cigarette Smoking Cessation: Results From the International Tobacco Control Four Country Survey. Nicotine Tob. Res. 2015, 17, 463–472. [Google Scholar] [CrossRef] [PubMed]
- Aboyans, V.; McClelland, R.L.; Allison, M.; McDermott, M.M.; Blumenthal, R.S.; Macura, K.; Criqui, M.H. Lower extremity peripheral artery disease in the absence of traditional risk factors. The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 2011, 214, 169–173. [Google Scholar] [CrossRef] [PubMed]
- Grenon, S.M.; Cohen, B.E.; Smolderen, K.; Vittinghoff, E.; Whooley, M.A.; Hiramoto, J. Peripheral arterial disease, gender, and depression in the Heart and Soul Study. J. Vasc. Surg. 2014, 60, 396–403. [Google Scholar] [CrossRef] [PubMed]
- Agarwala, A.; Michos, E.D.; Samad, Z.; Ballantyne, C.M.; Virani, S.S. The Use of Sex-Specific Factors in the Assessment of Women’s Cardiovascular Risk. Circulation 2020, 141, 592–599. [Google Scholar] [CrossRef] [PubMed]
- Kramer, C.K.; Campbell, S.; Retnakaran, R. Gestational diabetes and the risk of cardiovascular disease in women: A systematic review and meta-analysis. Diabetologia 2019, 62, 905–914. [Google Scholar] [CrossRef]
- Weissgerber, T.L.; Turner, S.T.; Bailey, K.R.; Mosley, T.H.; Kardia, S.L.; Wiste, H.J.; Miller, V.M.; Kullo, I.J.; Garovic, V.D. Hypertension in pregnancy is a risk factor for peripheral arterial disease decades after pregnancy. Atherosclerosis 2013, 229, 212–216. [Google Scholar] [CrossRef]
- Ray, J.G.; Vermeulen, M.J.; Schull, M.; A Redelmeier, D. Cardiovascular health after maternal placental syndromes (CHAMPS): Population-based retrospective cohort study. Lancet 2005, 366, 1797–1803. [Google Scholar] [CrossRef]
- Williams, J.S.; Macdonald, M.J. Influence of hormonal contraceptives on peripheral vascular function and structure in premenopausal females: A review. Am. J. Physiol. Circ. Physiol. 2021, 320, H77–H89. [Google Scholar] [CrossRef]
- Bosch, M.A.A.J.V.D.; Kemmeren, J.M.; Tanis, B.C.; Mali, W.P.T.M.; Helmerhorst, F.M.; Rosendaal, F.R.; Algra, A.; Van Der Graaf, Y. The RATIO study: Oral contraceptives and the risk of peripheral arterial disease in young women. J. Thromb. Haemost. 2003, 1, 439–444. [Google Scholar] [CrossRef] [PubMed]
- Zhang, J.; Xu, J.-H.; Qu, Q.-Q.; Zhong, G.-Q. Risk of cardiovascular and cerebrovascular events in polycystic ovarian syndrome women: A meta-analysis of cohort studies. Front. Cardiovasc. Med. 2020, 7, 184. [Google Scholar] [CrossRef] [PubMed]
- Talbott, E.O.; Guzick, D.S.; Sutton-Tyrrell, K.; McHugh-Pemu, K.P.; Zborowski, J.V.; Remsberg, K.E.; Kuller, L.H. Evidence for association between polycystic ovary syndrome and premature carotid atherosclerosis in middle-aged women. Arter. Thromb. Vasc. Biol. 2000, 20, 2414–2421. [Google Scholar] [CrossRef] [PubMed]
- Ding, D.-C.; Tsai, I.-J.; Wang, J.-H.; Lin, S.-Z.; Sung, F.-C. Coronary artery disease risk in young women with polycystic ovary syndrome. Oncotarget 2018, 9, 8756–8764. [Google Scholar] [CrossRef]
- Peters, A.E.S.; Woodward, M. Oestradiol and the risk of myocardial infarction in women: A cohort study of UK Biobank participants. Int. J. Epidemiol. 2021, 50, 1241–1249. [Google Scholar] [CrossRef]
- Pabon, M.; Cheng, S.; Altin, S.E.; Sethi, S.S.; Nelson, M.D.; Moreau, K.L.; Hamburg, N.; Hess, C.N. Sex Differences in Peripheral Artery Disease. Circ. Res. 2022, 130, 496–511. [Google Scholar] [CrossRef]
- Hsia, J.; Criqui, M.H.; Herrington, D.M.; Manson, J.E.; Wu, L.; Heckbert, S.R.; Allison, M.; McDermott, M.M.; Robinson, J.; Masaki, K. Conjugated equine estrogens and peripheral arterial disease risk: The Women’s Health Initiative. Am. Heart J. 2006, 152, 170–176. [Google Scholar] [CrossRef]
- Jelani, Q.; Mena-Hurtado, C.; Burg, M.; Soufer, R.; Gosch, K.; Jones, P.G.; Spertus, J.A.; Safdar, B.; Smolderen, K.J. Relationship between depressive symptoms and health status in peripheral artery disease: Role of sex differences. J. Am. Heart Assoc. 2020, 9, e014583. [Google Scholar] [CrossRef]
- A Blumenthal, J.; Lett, H.S.; A Babyak, M.; White, W.; Smith, P.K.; Mark, D.; Jones, R.; Mathew, J.P.; Newman, M.F. Depression as a risk factor for mortality after coronary artery bypass surgery. Lancet 2003, 362, 604–609. [Google Scholar] [CrossRef]
- Edmondson, D.; Richardson, S.; Falzon, L.; Davidson, K.; Mills, M.A.; Neria, Y. Posttraumatic Stress Disorder Prevalence and Risk of Recurrence in Acute Coronary Syndrome Patients: A Meta-analytic Review. PLoS ONE 2012, 7, e38915. [Google Scholar] [CrossRef]
- Vaccarino, V.; Almuwaqqat, Z.; Kim, J.H.; Hammadah, M.; Shah, A.J.; Ko, Y.-A.; Elon, L.; Sullivan, S.; Shah, A.; Alkhoder, A.; et al. Association of Mental Stress–Induced Myocardial Ischemia With Cardiovascular Events in Patients With Coronary Heart Disease. JAMA J. Am. Med. Assoc. 2021, 326, 1818–1828. [Google Scholar] [CrossRef] [PubMed]
- Samad, Z.; Boyle, S.; Ersboll, M.; Vora, A.N.; Zhang, Y.; Becker, R.C.; Williams, R.; Kuhn, C.; Ortel, T.L.; Rogers, J.G.; et al. Sex Differences in Platelet Reactivity and Cardiovascular and Psychological Response to Mental Stress in Patients With Stable Ischemic Heart Disease. J. Am. Coll. Cardiol. 2014, 64, 1669–1678. [Google Scholar] [CrossRef] [PubMed]
- Paine, N.J.; Bacon, S.L.; Pelletier, R.; Arsenault, A.; Diodati, J.G.; Lavoie, K.L. Do Women With Anxiety or Depression Have Higher Rates of Myocardial Ischemia During Exercise Testing Than Men? Circ. Cardiovasc. Qual. Outcomes 2016, 9, S53–S61. [Google Scholar] [CrossRef] [PubMed]
- Poole, L.; Leigh, E.; Kidd, T.; Ronaldson, A.; Jahangiri, M.; Steptoe, A. The combined association of depression and socioeconomic status with length of post-operative hospital stay following coronary artery bypass graft surgery: Data from a prospective cohort study. J. Psychosom. Res. 2013, 76, 34–40. [Google Scholar] [CrossRef]
- Smolderen, K.G.; Spertus, J.A.; Vriens, P.W.; Kranendonk, S.; Nooren, M.; Denollet, J. Younger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms. J. Vasc. Surg. 2010, 52, 637–644. [Google Scholar] [CrossRef]
- Kurmann, R.D.; Mankad, R. Atherosclerotic vascular disease in the autoimmune rheumatologic woman. Clin. Cardiol. 2018, 41, 258–263. [Google Scholar] [CrossRef]
- Crowson, C.S.; Matteson, E.L.; Myasoedova, E.; Michet, C.J.; Ernste, F.C.; Warrington, K.; Davis, J.; Hunder, G.G.; Therneau, T.M.; Gabriel, S.E. The lifetime risk of adult-onset rheumatoid arthritis and other inflammatory autoimmune rheumatic diseases. Arthritis Care Res. 2010, 63, 633–639. [Google Scholar] [CrossRef]
- Brevetti, G.; Giugliano, G.; Brevetti, L.; Hiatt, W.R. Inflammation in Peripheral Artery Disease. Circulation 2010, 122, 1862–1875. [Google Scholar] [CrossRef]
- Shovman, O.; Tiosano, S.; Comaneshter, D.; Cohen, A.D.; Amital, H.; Sherf, M. Aortic aneurysm associated with rheumatoid arthritis: A population-based cross-sectional study. Clin. Rheumatol. 2016, 35, 2657–2661. [Google Scholar] [CrossRef]
- Salata, K.; Almaghlouth, I.; Hussain, M.A.; de Mestral, C.; Greco, E.; Aljabri, B.A.; Mamdani, M.; Forbes, T.L.; Verma, S.; Al-Omran, M. Outcomes of abdominal aortic aneurysm repair among patients with rheumatoid arthritis. J. Vasc. Surg. 2021, 73, 1261–1268.e5. [Google Scholar] [CrossRef]
- Bradshaw, P.T.; Stevens, J.; Khankari, N.; Teitelbaum, S.L.; Neugut, A.I.; Gammon, M.D. Cardiovascular Disease Mortality Among Breast Cancer Survivors. Epidemiology 2016, 27, 6–13. [Google Scholar] [CrossRef] [PubMed]
- Khosrow-Khavar, F.; Filion, K.B.; Bouganim, N.; Suissa, S.; Azoulay, L. Aromatase Inhibitors and the Risk of Cardiovascular Outcomes in Women With Breast Cancer. Circulation 2020, 141, 549–559. [Google Scholar] [CrossRef] [PubMed]
- O’Neil, A.; Scovelle, A.J.; Milner, A.J.; Kavanagh, A. Gender/Sex as a Social Determinant of Cardiovascular Risk. Circulation 2018, 137, 854–864. [Google Scholar] [CrossRef] [PubMed]
- Eraso, L.H.; Fukaya, E.; Mohler, I.E.R.; Xie, D.; Sha, D.; Berger, J. Peripheral arterial disease, prevalence and cumulative risk factor profile analysis. Eur. J. Prev. Cardiol. 2012, 21, 704–711. [Google Scholar] [CrossRef]
- Nguyen, L.L.; Hevelone, N.; Rogers, S.O.; Bandyk, D.F.; Clowes, A.W.; Moneta, G.L.; Lipsitz, S.; Conte, M.S. Disparity in Outcomes of Surgical Revascularization for Limb Salvage. Circulation 2009, 119, 123–130. [Google Scholar] [CrossRef]
- Golledge, J.; Drovandi, A.; Rowbotham, S.; Velu, R.; Quigley, F.; Jenkins, J. Control of modifiable risk factors and major adverse cardiovascular events in people with peripheral artery disease and diabetes. World J. Diabetes 2021, 12, 883–892. [Google Scholar] [CrossRef]
- Ramkumar, N.; Suckow, B.D.; Brown, J.R.; Sedrakyan, A.; Cronenwett, J.L.; Goodney, P.P. Sex-Based Assessment of Patient Presentation, Lesion Characteristics, and Treatment Modalities in Patients Undergoing Peripheral Vascular Intervention. Circ. Cardiovasc. Interv. 2018, 11, e005749. [Google Scholar] [CrossRef]
- Aday, A.W.; Everett, B.M. Statins in PAD: What are we waiting for? Circulation 2019, 137, 1447–1449. [Google Scholar] [CrossRef]
- Goldstein, K.M.; Zullig, L.L.; Bastian, L.A.; Bosworth, H.B. Statin Adherence: Does Gender Matter? Curr. Atheroscler. Rep. 2016, 18, 63. [Google Scholar] [CrossRef]
- Nanna, M.G.; Wang, T.Y.; Xiang, Q.; Goldberg, A.C.; Robinson, J.G.; Roger, V.L.; Virani, S.S.; Wilson, P.W.; Louie, M.J.; Koren, A.; et al. Sex Differences in the Use of Statins in Community Practice. Circ. Cardiovasc. Qual. Outcomes 2019, 12, e005562. [Google Scholar] [CrossRef]
- Lau, E.S.; Braunwald, E.; Morrow, D.A.; Giugliano, R.P.; Antman, E.M.; Gibson, C.M.; Scirica, B.M.; Bohula, E.A.; Wiviott, S.D.; Bhatt, D.L.; et al. Sex, Permanent Drug Discontinuation, and Study Retention in Clinical Trials. Circulation 2021, 143, 685–695. [Google Scholar] [CrossRef] [PubMed]
- Antithrombotic Trialists. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. Bmj 2002, 324, 71–86. [Google Scholar] [CrossRef] [PubMed]
- Pâquet, M.; Pilon, D.; Tétrault, J.-P.; Carrier, N. Protective Vascular Treatment of Patients with Peripheral Arterial Disease: Guideline Adherence According to Year, Age and Gender. Can. J. Public Health 2010, 101, 96–100. [Google Scholar] [CrossRef]
- Kaul, S. Do Women Really Respond Differently to Antiplatelet Therapies? J. Am. Coll. Cardiol. 2017, 69, 1560–1563. [Google Scholar] [CrossRef] [PubMed]
- Lee, K.K.; Welton, N.; Shah, A.; Adamson, P.D.; Dias, S.; Anand, A.; Newby, E.D.; Mills, N.; A McAllister, D. Differences in relative and absolute effectiveness of oral P2Y12 inhibition in men and women: A meta-analysis and modelling study. Heart 2018, 104, 657–664. [Google Scholar] [CrossRef]
- Strauss, S.A.; Huynh, C.; Seo, C.; Kobewka, D.; Jetty, P.; Roberts, D.J.; Carrier, M. Antithrombotic Therapy in Women With Peripheral Artery Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J. Vasc. Surg. 2021, 74, e435–e437. [Google Scholar] [CrossRef]
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Pouncey, A.L.; Woodward, M. Sex-Specific Differences in Cardiovascular Risk, Risk Factors and Risk Management in the Peripheral Arterial Disease Population. Diagnostics 2022, 12, 808. https://doi.org/10.3390/diagnostics12040808
Pouncey AL, Woodward M. Sex-Specific Differences in Cardiovascular Risk, Risk Factors and Risk Management in the Peripheral Arterial Disease Population. Diagnostics. 2022; 12(4):808. https://doi.org/10.3390/diagnostics12040808
Chicago/Turabian StylePouncey, Anna Louise, and Mark Woodward. 2022. "Sex-Specific Differences in Cardiovascular Risk, Risk Factors and Risk Management in the Peripheral Arterial Disease Population" Diagnostics 12, no. 4: 808. https://doi.org/10.3390/diagnostics12040808
APA StylePouncey, A. L., & Woodward, M. (2022). Sex-Specific Differences in Cardiovascular Risk, Risk Factors and Risk Management in the Peripheral Arterial Disease Population. Diagnostics, 12(4), 808. https://doi.org/10.3390/diagnostics12040808