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Case Report
Peer-Review Record

CDX2- and PAX8-Expressing Subtypes in Female Urethral Adenocarcinoma: Pathogenesis Insights through Immunohistochemical and Morphological Analyses

Diagnostics 2023, 13(14), 2408; https://doi.org/10.3390/diagnostics13142408
by Emiko Sugawara 1,2, Yasuyuki Shigematsu 1,2, Gulanbar Amori 1,2, Keisuke Sugita 1,2, Junji Yonese 3, Kengo Takeuchi 1,2,4 and Kentaro Inamura 1,2,*
Reviewer 1:
Reviewer 2:
Diagnostics 2023, 13(14), 2408; https://doi.org/10.3390/diagnostics13142408
Submission received: 16 May 2023 / Revised: 13 July 2023 / Accepted: 17 July 2023 / Published: 19 July 2023
(This article belongs to the Section Pathology and Molecular Diagnostics)

Round 1

Reviewer 1 Report

This study aimed to evaluate the immunohistochemical and morphological characterization of female uretheral adenocarcinoma based on semi-comprehensive immunohistochemical analysis and detailed morphological evaluations. I suggest a few addition and modification for the better understanding.

-       Please show the table of the significant studies on CDX2 and PAX8 in urethral adenocarcinoma.

 

-       Please add the sufficient discussion about it.

 Minor editing of English language required

Author Response

Please refer to the attached file.

Author Response File: Author Response.docx

Reviewer 2 Report

The study is very interesting and gives us important news. The methodology is correct and the conclusions are in line with the study aims. So, I have only one minor comment: please discuss the role of tissue-associated inflammation in the patients' outcomes.

Author Response

Please refer to the attached file.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

It's corrected well enough that it can be published.

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