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Diagnostics
Volume 13
Issue 14
10.3390/diagnostics13142425
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Review
Peer-Review Record

The Pathophysiology of Collateral Circulation in Acute Ischemic Stroke

Diagnostics 2023, 13(14), 2425; https://doi.org/10.3390/diagnostics13142425
by Marilena Mangiardi 1,*,†, Adriano Bonura 2,†, Gianmarco Iaccarino 2,†, Michele Alessiani 2,†, Maria Cristina Bravi 2, Domenica Crupi 2, Francesca Romana Pezzella 2, Sebastiano Fabiano 3, Enrico Pampana 3, Francesco Stilo 4, Guido Alfano 5 and Sabrina Anticoli 2
Reviewer 1:
Alessia Carboni
Reviewer 2:
Matteo Foschi
Diagnostics 2023, 13(14), 2425; https://doi.org/10.3390/diagnostics13142425
Submission received: 22 June 2023 / Revised: 8 July 2023 / Accepted: 18 July 2023 / Published: 20 July 2023
(This article belongs to the Special Issue Risk Factors for Acute Ischemic Stroke)

Round 1

Reviewer 1 Report

The title indicates adequately the study design.    

The abstract provides an informative and balanced summary of the study.  

The manuscript is well structured with an adequate and clear presentation of scientific review of the literature.  

The cited references contains recent publications.   

The discussion is fluid, and the passages are clear.     

Images are well explained but  insufficient. The DWI/ADC sequences and especially PWI images should be added.

The manuscript is fluid and clear. Minor editing of English language is required.

Author Response

Dear reviewer,

thank you for revision. As requested I add more images in this paper, DWI/ADC and TC perfusion images. 

 

Author Response File: Author Response.docx

Reviewer 2 Report

The review provides a comprehensive overview on pathophysiology, clinical and therapeutic aspects of collateral cerebral circulation in acute ischemic stroke. The topic is of interest, since collateral flow is an important factor to be considered when chosing the best treatment option for patients with acute stroke and harbors relevant prognostic implications. The manuscript is globally well written and only few minor edits are required in my opinion:

- please better describe in the introduction current gold standards on extended reperfusion time window for both IVT and EVT.  It could be worth  to briefly expand citing controversies and reasons hampering the effectiveness of appropriately administered reperfusion treatments in some cases (beyond poor collateral circulation).

- I suggest to expand the discussion section by providing authors' personal point of view of future challenges and best imaging modality to improve the selection of patients for reperfusion therapies taking into more account the state of collateral circulation in treament decisions.

 

 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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