Measuring the Whole Wall Thickness of the Common Femoral Vein as a Distinctive Diagnostic Tool to Distinguish Behçet’s Disease Presenting with Oral Ulcers from Recurrent Aphthous Stomatitis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design, Setting, and Ethics
2.2. Participants and Eligibility Criteria
2.3. Venous Doppler Ultrasonography
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Confounders | Healthy Control | Idiopathic RAS | Behçet’s Disease | p-Value | |
---|---|---|---|---|---|
(n = 70) | (n = 85) | (n = 84) | |||
Age (years) | 34 ± 10 | 36 ± 11 | 37 ± 9 | 0.065 | |
Sex | Man | 41 (58.6%) | 46 (54.1%) | 50 (59.5%) | 0.753 |
Woman | 29 (41.4%) | 39 (45.9%) | 34 (40.5%) | ||
BMI (kg/m2) | 25.8 ± 3.0 | 24.9 ± 3.2 | 25.1 ± 3.2 | 0.059 | |
Waist circumference (cm) | 92 ± 8 | 89 ± 16 | 91 ± 12 | 0.069 | |
The duration of complaints (year) | - | 4.5 ± 1.7 | 4.7 ± 1.8 | 0.120 | |
Colchicine usage, currently | Yes | - | 23 (27.1%) | 70 (83.3%) | <0.001 * |
No | 62 (72.9%) | 14 (16.7%) | |||
Colchicine duration (year), if yes | - | 1.9 ± 1.3 | 2.6 ± 3.7 | 0.377 * | |
Smoking | Yes, currently | 8 (11.4%) | 9 (10.6%) | 9 (10.7%) | 0.621 |
Ex smoker | 8 (11.4%) | 4 (4.7%) | 6 (7.1%) | ||
No, never | 54 (77.1%) | 72 (84.7%) | 69 (82.1%) | ||
Total cigarette exposure (pack/year) | 16.3 (10.5) | 8.2 (9.4%) | 13.5 (10.7) | 0.104 | |
Alcoholic beverage consumption | Yes | 9 (12.9%) | 8 (9.4%) | 7 (8.3%) | 0.360 |
No | 61 (87.1%) | 77 (90.6%) | 77 (91.7%) | ||
Others | |||||
Pathergy test | Not done | 70 (100%) | - | - | N/A |
Negative | - | 85 (100%) | 54 (64.2%) | ||
Positive | - | 0 (0%) | 30 (35.7%) | ||
ESR (mm/hour) | 10 ± 13 | 18 ± 15 | 16 ± 14 | 0.061 | |
CRP (mg/l) | 2.6 ± 2.5 | 10.9 ± 19.9 | 6.7 ± 11.8 | 0.296 |
Ultrasonographic Parameters | Healthy Control | Idiopathic RAS | Behçet’s Disease | p-Value | |
---|---|---|---|---|---|
(n = 70) | (n = 85) | (n = 84) | |||
WWT of CFV (mm) | |||||
Right | 0.56 ± 0.08 | 0.54 ± 0.09 | 0.68 ± 0.12 | <0.001 a,b | |
Left | 0.57 ± 0.10 | 0.55 ± 0.10 | 0.68 ± 0.11 | <0.001 a,b | |
Mean of right and left | 0.56 ± 0.09 | 0.54 ± 0.09 | 0.68 ± 0.11 | <0.001 a,b | |
IMT of CFV (mm) | |||||
Right | 0.245 ± 0.018 | 0.234 ± 0.030 | 0.242 ± 0.044 | 0.096 | |
Left | 0.249 ± 0.026 | 0.239 ± 0.033 | 0.241 ± 0.041 | 0.211 | |
Mean of right and left | 0.247 ± 0.019 | 0.237 ± 0.030 | 0.241 ± 0.041 | 0.116 |
AUROC | Cutoff Value | Sensitivity | Specificity | Pos LR | Neg LR | Accuracy Rate | p-Value | |
---|---|---|---|---|---|---|---|---|
WWT of CFV (mm) | 0.800 | >0.58 | 79.8% | 64.7% | 2.26 | 0.31 | 72.2% | <0.001 |
βi | Odds Ratio | 95% CI | Wald Value | Cox and Snell R2 | Nagelkerke R2 | p-Value | ||
---|---|---|---|---|---|---|---|---|
Lower | Upper | |||||||
WWT of CFV > 0.58 mm | 1.86 | 6.41 | 3.44 | 11.96 | 34.15 | 0.154 | 0.212 | <0.001 |
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Erturk, A.; Sarıkaya, Y.; Coşkun, H.; Turan, Ç. Measuring the Whole Wall Thickness of the Common Femoral Vein as a Distinctive Diagnostic Tool to Distinguish Behçet’s Disease Presenting with Oral Ulcers from Recurrent Aphthous Stomatitis. Diagnostics 2023, 13, 2705. https://doi.org/10.3390/diagnostics13162705
Erturk A, Sarıkaya Y, Coşkun H, Turan Ç. Measuring the Whole Wall Thickness of the Common Femoral Vein as a Distinctive Diagnostic Tool to Distinguish Behçet’s Disease Presenting with Oral Ulcers from Recurrent Aphthous Stomatitis. Diagnostics. 2023; 13(16):2705. https://doi.org/10.3390/diagnostics13162705
Chicago/Turabian StyleErturk, Adem, Yasin Sarıkaya, Hüseyin Coşkun, and Çağrı Turan. 2023. "Measuring the Whole Wall Thickness of the Common Femoral Vein as a Distinctive Diagnostic Tool to Distinguish Behçet’s Disease Presenting with Oral Ulcers from Recurrent Aphthous Stomatitis" Diagnostics 13, no. 16: 2705. https://doi.org/10.3390/diagnostics13162705
APA StyleErturk, A., Sarıkaya, Y., Coşkun, H., & Turan, Ç. (2023). Measuring the Whole Wall Thickness of the Common Femoral Vein as a Distinctive Diagnostic Tool to Distinguish Behçet’s Disease Presenting with Oral Ulcers from Recurrent Aphthous Stomatitis. Diagnostics, 13(16), 2705. https://doi.org/10.3390/diagnostics13162705