Hyperoxic BOLD-MRI-Based Characterization of Breast Cancer Molecular Subtypes Is Independent of the Supplied Amount of Oxygen: A Preclinical Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Cell Culture and Mouse Model
2.2. MRI
2.3. Image Postprocessing
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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21% O2 [s−1] | 41% O2 [s−1] | 71% O2 [s−1] | 100% O2 [s−1] | |
---|---|---|---|---|
Luminal A | 145.19, 67.56 | −13.46, 14.20 a | −20.37, 17.06 | −28.42, 24.35 a |
Her2+ | 140.60, 33.13 | −0.76, 20.80 *** | 1.80, 23.19 ** | −2.85, 21.95 *** |
Triple negative | 110.06, 20.93 | −5.32, 13.15 ** | −10.58, 9.38 ** | −11.64, 9.15 *** |
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Bartsch, S.J.; Ehret, V.; Friske, J.; Fröhlich, V.; Laimer-Gruber, D.; Helbich, T.H.; Pinker, K. Hyperoxic BOLD-MRI-Based Characterization of Breast Cancer Molecular Subtypes Is Independent of the Supplied Amount of Oxygen: A Preclinical Study. Diagnostics 2023, 13, 2946. https://doi.org/10.3390/diagnostics13182946
Bartsch SJ, Ehret V, Friske J, Fröhlich V, Laimer-Gruber D, Helbich TH, Pinker K. Hyperoxic BOLD-MRI-Based Characterization of Breast Cancer Molecular Subtypes Is Independent of the Supplied Amount of Oxygen: A Preclinical Study. Diagnostics. 2023; 13(18):2946. https://doi.org/10.3390/diagnostics13182946
Chicago/Turabian StyleBartsch, Silvester J., Viktoria Ehret, Joachim Friske, Vanessa Fröhlich, Daniela Laimer-Gruber, Thomas H. Helbich, and Katja Pinker. 2023. "Hyperoxic BOLD-MRI-Based Characterization of Breast Cancer Molecular Subtypes Is Independent of the Supplied Amount of Oxygen: A Preclinical Study" Diagnostics 13, no. 18: 2946. https://doi.org/10.3390/diagnostics13182946