Classifying Breast Cancer Metastasis Based on Imaging of Tumor Primary and Tumor Biology
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Luminal A
3.1.1. Imaging Findings
Mammography and Ultrasound
MRI
Imaging and Metastases
3.1.2. Treatment
3.2. Luminal B
3.2.1. Imaging Findings
Mammography and Ultrasound
MRI
Imaging and Metastases
3.2.2. Treatment
3.3. Basal-like
3.3.1. Imaging Findings
Mammography and Ultrasound
MRI
Imaging and Metastases
3.3.2. Treatment
3.4. Human Epidermal Growth Factor Receptor Type 2 Positive (HER2+)
3.4.1. Imaging Findings
Mammography and Ultrasound
MRI
Imaging and Metastases
3.4.2. Treatment
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Molecular Subtypes | Luminal A | Luminal B | HER2+ | TN | |
---|---|---|---|---|---|
(HER2−) | (HER2+) | ||||
Biomarkers | ER+ PR+ HER2− Ki67low | ER+ PR− HER2− Ki67high | ER+ PR−/+ HER2+ Ki67low/high | ER− PR− HER2+ Ki67high | ER− PR− HER2− Ki67high |
Frequency of Cases (%) | 40–50 | 20–30 | 15–20 | 10–20 | |
Histological Grade | Well Differentiated (Grade I) | Moderately Differentiated (Grade II) | Little Differentiated (Grade III) | Little Differentiated (Grade III) | |
Prognosis | Good | Intermediate | Poor | Poor | |
Response to Therapies | Endocrine | Endocrine Chemotherapy | Endocrine Chemotherapy Target Therapy | Target Therapy Chemotherapy | Chemotherapy PARP Inhibitors |
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Awad, B.; Chandora, A.; Bassett, B.; Hermecz, B.; Woodard, S. Classifying Breast Cancer Metastasis Based on Imaging of Tumor Primary and Tumor Biology. Diagnostics 2023, 13, 437. https://doi.org/10.3390/diagnostics13030437
Awad B, Chandora A, Bassett B, Hermecz B, Woodard S. Classifying Breast Cancer Metastasis Based on Imaging of Tumor Primary and Tumor Biology. Diagnostics. 2023; 13(3):437. https://doi.org/10.3390/diagnostics13030437
Chicago/Turabian StyleAwad, Barbara, Agni Chandora, Ben Bassett, Brittany Hermecz, and Stefanie Woodard. 2023. "Classifying Breast Cancer Metastasis Based on Imaging of Tumor Primary and Tumor Biology" Diagnostics 13, no. 3: 437. https://doi.org/10.3390/diagnostics13030437