Contrast Enhanced Mammography (CEM) Enhancing Asymmetry: Single-Center First Case Analysis
Abstract
:1. Introduction
2. Materials and Methods
Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Fisher Exact Test—Enhancement Conspicuity/Cancer-No Cancer | |||
---|---|---|---|
Enhancement conspicuity | Cancer (n) | No Cancer (n) | p-value |
Low | 3 | 23 | 0.071 |
Moderate | 6 | 14 | |
High | 10 | 8 | |
Enhancement conspicuity | Cancer (n) | No Cancer (n) | p-value |
Low | 3 | 23 | 0.0117 |
Not Low (Moderate and High) | 16 | 22 | |
Enhancement conspicuity | Cancer (n) | No Cancer (n) | p-value |
Moderate | 6 | 14 | 1.0000 |
Not Moderate (Low and High) | 13 | 31 | |
Enhancement conspicuity | Cancer (n) | No Cancer (n) | p-value |
High | 10 | 8 | 0.0071 |
Not High (Low and Moderate) | 9 | 37 |
B5 | |||
---|---|---|---|
GRADING | HYSTOLOGY | ||
G1 (10/19) | |||
Invasive tubular carcinoma | 4 | ||
Invasive ductal carcinoma | 3 | ||
Ductal and papillary carcinoma | 1 | ||
Lobular carcinoma | 1 | ||
Colloid carcinoma | 1 | ||
G2 (5/19) | |||
Ductal and papillary carcinoma | 1 | ||
Invasive ductal carcinoma | 1 | ||
Ductal in situ carcinoma | 2 | ||
Invasive lobular carcinoma | 1 | ||
G3 (4/19) | |||
Invasive ductal carcinoma | 2 | ||
Lobular and ductal carcinoma | 1 | ||
Ductal and colloid carcinoma | 1 | ||
TOTAL | 19 | ||
B3 | Atypical ductal hyperplasia | 2 | |
Radial scar | 1 | ||
Classical lobular neoplasia | 1 | ||
Flat epithelial atypia | 1 | ||
TOTAL | 5 | ||
B2 | Fibrocystic breast change | 16 | |
Fibroadenoma | 2 | ||
Phlogosis | 2 | ||
Sclerosing adenosis | 1 | ||
Bening adenomyoepithelioma | 1 | ||
TOTAL | 22 |
Patient Age | Additional/Principal | Size (mm) | Histology Results after Surgery | Grading | Her2 Status | Molecular Subtype |
---|---|---|---|---|---|---|
82 | Additional | 7 | Colloid carcinoma | G1 | Neg. | LUM B |
48 | Additional | 6 | Invasive ductal carcinoma | G1 | Neg. | LUM A |
70 | Principal | 4 | Invasive ductal carcinoma | G1 | Neg. | LUM A |
59 | Additional | 9 | Lobular carcinoma | G1 | Neg. | LUM A |
73 | Additional | 3 | Invasive tubular carcinoma | G1 | Neg. | LUM A |
77 | Additional | 4 | Invasive tubular carcinoma | G1 | Neg. | LUM B |
78 | Additional | 5 | Invasive tubular carcinoma | G1 | Neg. | LUM A |
73 | Additional | 7 | Invasive ductal carcinoma | G1 | Neg. | LUM B |
73 | Principal | 4 | Ductal and papillary carcinoma | G1 | Neg. | LUM A |
53 | Principal | 11 | Invasive tubular carcinoma | G1 | Neg. | LUM A |
46 | Principal | 4 | Ductal in situ carcinoma | G2 | Neg. | LUM A |
60 | Additional | 5 | Ductal in situ carcinoma | G2 | Neg. | LUM A |
53 | Principal | 11 | Invasive ductal carcinoma | G2 | Neg. | LUM B |
46 | Principal | 9 | Ductal and papillary carcinoma | G2 | Neg. | LUM B |
71 | Principal | 14 | Invasive lobular carcinoma | G2 | Neg. | LUM A |
51 | Additional | 3 | Invasive ductal carcinoma | G3 | Neg. | Basal-like |
42 | Additional | 15 | Ductal and colloid carcinoma | G3 | Neg. | LUM B |
48 | Principal | 2.5 | Invasive ductal carcinoma | G3 | Neg. | LUM B |
62 | Additional | 9 | Lobular and ductal carcinoma | G3 | Neg. | LUM B |
Patients | EA | p Value | ||
---|---|---|---|---|
Benign (%) | Malignant (%) | |||
INDICATION | ||||
Pre-surgical assessment | 36 | 23 (63.9%) | 13 (36.1%) | ns |
Problem-solving | 28 | 22 (78.6%) | 6 (21.4%) | ns |
BREAST COMPOSITION | ||||
A | 4 | 1 (25%) | 3 (75%) | ns |
B | 36 | 24 (66.7%) | 12 (33.3%) | ns |
C | 15 | 13 (86.7%) | 2 (13.3%) | ns |
D | 9 | 7 (77.8%) | 2 (22.2%) | ns |
BPE | ||||
Minimal | 23 | 16 (69.6%) | 7 (30.4%) | ns |
Mild | 20 | 12 (60%) | 8 (40%) | ns |
Moderate | 13 | 10 (76.9%) | 3 (23.1%) | ns |
High | 8 | 7 (87.5%) | 1 (12.5%) | ns |
CORRELATE | ||||
Focal Density | 6 | 4 (66.7%) | 2 (33.3%) | ns |
Opacity | 19 | 14 (73.7%) | 5 (26.3%) | ns |
Microcalcifications | 12 | 11 (91.7%) | 1 (8.3%) | ns |
Architectural distortion | 8 | 3 (37.5%) | 5 (62.5%) | ns |
US hypoechoic masses with circumscribed margins | 10 | 5 (50%) | 5 (50%) | ns |
US masses with indistinct margins | 6 | 5 (83.3%) | 1 (16.7%) | ns |
MRI mass/non-mass/focus | 3 | 3 (100%) | 0 | ns |
BIOPSY | ||||
Percutaneous CNB | 12 | 6 (50%) | 6 (50%) | |
Stereotactic VABB | 32 | 20 (62.5%) | 12 (37.5%) | |
MRI-biopsy | 1 | 1 (100%) | 0 | |
No biopsy | 19 | 18 (94.7%) | 1 (5.3%) | |
PRINCIPAL/ADDITIONAL | ||||
Principal | 19 | 11 (57.9%) | 8 (42.1%) | ns |
Additional | 45 | 34 (75.6%) | 11 (24.4%) | ns |
SIZE | ||||
Mean (mm) | 8.51 [3–23] | 12.05 [4–40] | p: 0.0274 | |
Median (mm) | 8 | 8 | ns | |
INTERNAL ENHANCING PATTERN | ||||
Homogeneous | 35 | 29 (82.9%) | 6 (17.1%) | ns |
Heterogeneous | 29 | 16 (55.2%) | 13 (44.8%) | ns |
ENHANCING CONSPICUITY | ||||
Low | 26 | 23 (88.5%) | 3 (11.5%) | p: 0.0117 |
Moderate | 20 | 14 (70%) | 6 (30%) | ns |
High | 18 | 8 (44.4%) | 10 (55.6%) | p: 0.0071 |
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Migliaro, G.; Bicchierai, G.; Valente, P.; Di Naro, F.; De Benedetto, D.; Amato, F.; Boeri, C.; Vanzi, E.; Miele, V.; Nori, J. Contrast Enhanced Mammography (CEM) Enhancing Asymmetry: Single-Center First Case Analysis. Diagnostics 2023, 13, 1011. https://doi.org/10.3390/diagnostics13061011
Migliaro G, Bicchierai G, Valente P, Di Naro F, De Benedetto D, Amato F, Boeri C, Vanzi E, Miele V, Nori J. Contrast Enhanced Mammography (CEM) Enhancing Asymmetry: Single-Center First Case Analysis. Diagnostics. 2023; 13(6):1011. https://doi.org/10.3390/diagnostics13061011
Chicago/Turabian StyleMigliaro, Giuliano, Giulia Bicchierai, Pietro Valente, Federica Di Naro, Diego De Benedetto, Francesco Amato, Cecilia Boeri, Ermanno Vanzi, Vittorio Miele, and Jacopo Nori. 2023. "Contrast Enhanced Mammography (CEM) Enhancing Asymmetry: Single-Center First Case Analysis" Diagnostics 13, no. 6: 1011. https://doi.org/10.3390/diagnostics13061011