The Usage of Different Hyaluronic-Acid-Containing Artificial Tears and the Treatment Outcome of Intense Pulsed Light Therapy for Dry Eye Disease: A Retrospective Cohort Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participant Selection
2.2. Intense Pulsed Light Therapy
2.3. Dry Eye Evaluation
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Feature | 0.1% HA Group (N: 42) | 0.15% HA Group (N: 40) | p |
---|---|---|---|
Age (years, mean ± SD) | 46.23 ± 11.72 | 45.96 ± 12.51 | 0.905 |
Sex (male: female) | 16:26 | 17:23 | 0.822 |
Ocular disease | 0.526 | ||
Retinal disorder | 2 | 1 | |
Glaucoma | 0 | 0 | |
Other | 1 | 0 | |
Ocular surgery | 0.999 | ||
Retinal surgery | 1 | 0 | |
UDVA (LogMAR) | 0.38 ± 0.12 | 0.35 ± 0.13 | 0.260 |
Cycloplegia SE (D) | −2.91 ± 1.36 | −2.65 ± 1.27 | 0.342 |
IOP | 12.68 ± 2.74 | 12.89 ± 3.05 | 0.713 |
NITBUT | 8.72 ± 3.35 | 8.84 ± 3.60 | 0.826 |
Eyelid closure rate | 94.02 ± 5.69 | 93.78 ± 5.32 | 0.831 |
Lipid thickness | 0.269 | ||
Grade A–C | 25 | 18 | |
Grade D–E | 17 | 22 | |
TMH | 0.29 ± 0.10 | 0.28 ± 0.11 | 0.673 |
Meibomian gland loss rate | 28.59 ± 6.68 | 29.27 ± 6.31 | 0.624 |
Schirmer II test | 10.07 ± 4.63 | 9.84 ± 5.14 | 0.788 |
Ocular surface stain | 0.651 | ||
Grade 0–3 | 27 | 23 | |
Grade 4–6 | 15 | 17 | |
DED-related syndrome | 0.729 | ||
1 | 16 | 18 | |
2 | 16 | 15 | |
≥3 | 10 | 7 |
Outcome | 0.1% HA Group (N: 42) | 0.15% HA Group (N: 40) | p |
---|---|---|---|
UDVA | 0.37 ± 0.14 | 0.35 ± 0.12 | 0.468 |
SE | −2.90 ± 1.38 | −2.62 ± 1.28 | 0.313 |
IOP | 13.16 ± 2.48 | 12.57 ± 3.38 | 0.334 |
Schirmer II test | 11.74 ± 4.20 | 12.97 ± 3.46 | 0.101 |
NITBUT | 10.83 ± 3.14 | 12.46 ± 3.29 | 0.023 * |
Ocular surface stain | 0.788 | ||
Grade 0–3 | 34 | 31 | |
Grade 4–6 | 8 | 9 | |
DED-related syndrome | 0.508 | ||
1 | 24 | 25 | |
2 | 10 | 11 | |
≥3 | 8 | 4 |
Outcome (Reference: 0.10% HA Group) | aOR | 95% CI | p | |
---|---|---|---|---|
Lower | Upper | |||
Schirmer II test | 1.140 | 0.997 | 1.257 | 0.054 |
NITBUT | 1.238 | 1.014 | 1.377 | 0.039 * |
Ocular surface stain | 0.975 | 0.930 | 1.099 | 0.729 |
DED-related syndromes | 1.005 | 0.942 | 1.183 | 0.636 |
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Lee, C.-Y.; Yang, S.-F.; Chen, Y.-C.; Chang, C.-K. The Usage of Different Hyaluronic-Acid-Containing Artificial Tears and the Treatment Outcome of Intense Pulsed Light Therapy for Dry Eye Disease: A Retrospective Cohort Study. Diagnostics 2024, 14, 1796. https://doi.org/10.3390/diagnostics14161796
Lee C-Y, Yang S-F, Chen Y-C, Chang C-K. The Usage of Different Hyaluronic-Acid-Containing Artificial Tears and the Treatment Outcome of Intense Pulsed Light Therapy for Dry Eye Disease: A Retrospective Cohort Study. Diagnostics. 2024; 14(16):1796. https://doi.org/10.3390/diagnostics14161796
Chicago/Turabian StyleLee, Chia-Yi, Shun-Fa Yang, Yun-Chen Chen, and Chao-Kai Chang. 2024. "The Usage of Different Hyaluronic-Acid-Containing Artificial Tears and the Treatment Outcome of Intense Pulsed Light Therapy for Dry Eye Disease: A Retrospective Cohort Study" Diagnostics 14, no. 16: 1796. https://doi.org/10.3390/diagnostics14161796