Commercial Opportunity or Addressing Unmet Needs—Loop-Mediated Isothermal Amplification (LAMP) as the Future of Rapid Diagnostic Testing?

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The manuscript titled "Commercial opportunity or addressing unmet needs: Loop-mediated isothermal amplification (LAMP) as the future of rapid diagnostic testing?" offers a thorough and insightful analysis of LAMP technology's commercial potential and its ability to address unmet needs in rapid diagnostic testing. It is highly relevant and timely, given the growing demand for rapid, accurate, and cost-effective diagnostic tools. The authors present a comprehensive review supported by robust references, detailing LAMP's mechanism, advantages, and limitations. The manuscript is well-structured and clearly written, making complex concepts accessible. The use of multiple graphs to present the data enhances the clarity and impact of the findings, allowing readers to visualize key points effectively. Overall, I believe this manuscript is a valuable contribution to the field in its current form.

I found this study to be comprehensive and interesting to read. The graphs have significantly aided in improving the clarity of results and facilitating communication of the concept to readers. I highly recommend this manuscript for publication in the Diagnostics journal.

 

 

Author Response

Dear Reviewer,

Thank you for your positive and encouraging feedback on our manuscript. We are delighted to hear that you found our analysis thorough, insightful, and highly relevant. Your recognition of the manuscript's structure, clarity, and the effectiveness of the graphs in presenting our data is greatly appreciated.

We are grateful for your recommendation for publication in the Diagnostics journal and are pleased that our work is considered a valuable contribution to the field.

Kind regards,

The Authors 

Reviewer 2 Report

Comments and Suggestions for Authors

The reviewed manuscript is dedicated to studying patents and clinical trials related to LAMP. The study itself is interesting and timely because LAMP attracts growing interest with increasing numbers of published scientific articles and patents. The quality of the text is good; all conclusions are supported by the presented data. Only a few minor issues need to be mentioned:

Several figures seem to be of low quality.

Page 9, line 248: T. Pallidum is not italicized.

Page 14, line 454 “Covid-19”

Page 15, line 486 “Sars-Cov-2”

Author Response

Dear Reviewer,

Thank you for your thorough review and positive feedback on our manuscript. We are pleased to hear that you find the study interesting and timely, and that you appreciate the quality of our text. 

We appreciate your attention to detail and have noted your comments regarding the minor issues. We have addressed the following points:

1. We have improved the quality of Figure 8 and 9 to make it more clear. The other figures in the manuscript seem clear and are of high resolution. Please let us know if any specific figures need further attention.
2. We have italicized *T. pallidum* and other bacterial names on Page 9.
3. We have corrected the capitalization of "COVID-19" on Page 14, line 454.
4. We have corrected the capitalization of "SARS-CoV-2" on Page 15, line 486.

Thank you once again for your valuable feedback.

Kind regards,

The Authors