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Review

Non-Coding RNA Involved in the Pathogenesis of Atherosclerosis—A Narrative Review

by
Kajetan Kiełbowski
,
Justyna Żychowska
,
Estera Bakinowska
and
Andrzej Pawlik
*
Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Diagnostics 2024, 14(17), 1981; https://doi.org/10.3390/diagnostics14171981
Submission received: 15 July 2024 / Revised: 5 September 2024 / Accepted: 5 September 2024 / Published: 7 September 2024
(This article belongs to the Special Issue New Progress in Diagnosis and Management of Cardiovascular Diseases)

Abstract

Atherosclerosis is a highly prevalent condition associated with lipid accumulation in the intima layer of arterial blood vessels. The development of atherosclerotic plaques is associated with the incidence of major cardiovascular events, such as acute coronary syndrome or ischemic stroke. Due to the significant prevalence of atherosclerosis and its subclinical progression, it is associated with severe and potentially lethal complications. The pathogenesis of atherosclerosis is complex and not entirely known. The identification of novel non-invasive diagnostic markers and treatment methods that could suppress the progression of this condition is highly required. Non-coding RNA (ncRNA) involves several subclasses of RNA molecules. microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA) differently regulate gene expression. Importantly, these molecules are frequently dysregulated under pathological conditions, which is associated with enhanced or suppressed expression of their target genes. In this review, we aim to discuss the involvement of ncRNA in crucial mechanisms implicated in the pathogenesis of atherosclerosis. We summarize current evidence on the potential use of these molecules as diagnostic and therapeutic targets.
Keywords: atherosclerosis; cardiovascular diseases; non-coding RNA; epigenetics atherosclerosis; cardiovascular diseases; non-coding RNA; epigenetics

Share and Cite

MDPI and ACS Style

Kiełbowski, K.; Żychowska, J.; Bakinowska, E.; Pawlik, A. Non-Coding RNA Involved in the Pathogenesis of Atherosclerosis—A Narrative Review. Diagnostics 2024, 14, 1981. https://doi.org/10.3390/diagnostics14171981

AMA Style

Kiełbowski K, Żychowska J, Bakinowska E, Pawlik A. Non-Coding RNA Involved in the Pathogenesis of Atherosclerosis—A Narrative Review. Diagnostics. 2024; 14(17):1981. https://doi.org/10.3390/diagnostics14171981

Chicago/Turabian Style

Kiełbowski, Kajetan, Justyna Żychowska, Estera Bakinowska, and Andrzej Pawlik. 2024. "Non-Coding RNA Involved in the Pathogenesis of Atherosclerosis—A Narrative Review" Diagnostics 14, no. 17: 1981. https://doi.org/10.3390/diagnostics14171981

APA Style

Kiełbowski, K., Żychowska, J., Bakinowska, E., & Pawlik, A. (2024). Non-Coding RNA Involved in the Pathogenesis of Atherosclerosis—A Narrative Review. Diagnostics, 14(17), 1981. https://doi.org/10.3390/diagnostics14171981

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