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Multiple Pulmonary Involvement in the Rapidly Progressive Evolution of Rheumatoid Arthritis
by
Beatrice Mahler
Beatrice Mahler 1,2,
Mădălina Ioana Moșteanu
Mădălina Ioana Moșteanu 2,3,
Raluca Bobocea
Raluca Bobocea 2,
Iris Negoescu
Iris Negoescu 2,
Leonard Florentin Mircea
Leonard Florentin Mircea 2,*,
Adrian Tudor
Adrian Tudor 4,
Maria Teodora Bogdan
Maria Teodora Bogdan 1,
Alina Croitoru
Alina Croitoru 1,2,* and
Angela Stefania Marghescu
Angela Stefania Marghescu 4
1
Cardiothoracic Department, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, 020956 Bucharest, Romania
2
Pneumology Department, “Marius Nasta” Institute of Pneumology, 050159 Bucharest, Romania
3
Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
4
Pathology Department, “Marius Nasta” Institute of Pneumology, 050159 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
Diagnostics 2024, 14(19), 2175; https://doi.org/10.3390/diagnostics14192175 (registering DOI)
Submission received: 7 July 2024
/
Revised: 15 September 2024
/
Accepted: 27 September 2024
/
Published: 29 September 2024
Abstract
A 66-year-old man, a 40-year smoker, was diagnosed with rheumatoid arthritis in 2018. He was treated for one year with methotrexate, and, later in 2020, he was diagnosed with interstitial pulmonary fibrosis. In 2022, treatment with nintedanib was initiated, with clinical improvement being indicated but without showing a functional or imaging benefit. The evolution of the disease was rapidly progressive and unfavorable, with death occurring due to pulmonary thromboembolism. Following the autopsy, triple lesions of the RA at the lung level were confirmed: interstitial, of the NSIP type with a fibrosing character at the level of the lower airways of the bilateral bronchiectasis type, and vascular damage due to pulmonary thromboembolism secondary to chronic inflammation.
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MDPI and ACS Style
Mahler, B.; Moșteanu, M.I.; Bobocea, R.; Negoescu, I.; Mircea, L.F.; Tudor, A.; Bogdan, M.T.; Croitoru, A.; Marghescu, A.S.
Multiple Pulmonary Involvement in the Rapidly Progressive Evolution of Rheumatoid Arthritis. Diagnostics 2024, 14, 2175.
https://doi.org/10.3390/diagnostics14192175
AMA Style
Mahler B, Moșteanu MI, Bobocea R, Negoescu I, Mircea LF, Tudor A, Bogdan MT, Croitoru A, Marghescu AS.
Multiple Pulmonary Involvement in the Rapidly Progressive Evolution of Rheumatoid Arthritis. Diagnostics. 2024; 14(19):2175.
https://doi.org/10.3390/diagnostics14192175
Chicago/Turabian Style
Mahler, Beatrice, Mădălina Ioana Moșteanu, Raluca Bobocea, Iris Negoescu, Leonard Florentin Mircea, Adrian Tudor, Maria Teodora Bogdan, Alina Croitoru, and Angela Stefania Marghescu.
2024. "Multiple Pulmonary Involvement in the Rapidly Progressive Evolution of Rheumatoid Arthritis" Diagnostics 14, no. 19: 2175.
https://doi.org/10.3390/diagnostics14192175
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