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Open AccessCase Report
Herpes Simplex Keratitis Following Corneal Crosslinking for Keratoconus: A One-Year Case Series Follow-Up
by
Freja Bagatin
Freja Bagatin ,
Ivana Radman
Ivana Radman ,
Karla Ranđelović
Karla Ranđelović ,
Ivanka Petric Vicković
Ivanka Petric Vicković *,
Valentina Lacmanović Lončar
Valentina Lacmanović Lončar ,
Renata Iveković
Renata Iveković and
Zoran Vatavuk
Zoran Vatavuk
Department of Ophthalmology, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Diagnostics 2024, 14(20), 2267; https://doi.org/10.3390/diagnostics14202267 (registering DOI)
Submission received: 17 August 2024
/
Revised: 22 September 2024
/
Accepted: 8 October 2024
/
Published: 11 October 2024
Abstract
Corneal crosslinking (CXL) is a medical procedure used to treat keratoconus. CXL works by strengthening the collagen fibers of the cornea through the application of riboflavin (vitamin B2) and ultraviolet (UV) light, which helps to stabilize the cornea and prevent further deterioration. There is a recognized risk that CXL can trigger the reactivation of dormant herpes simplex virus (HSV), leading to herpetic keratitis even in patients with no history of herpetic disease. We examined the medical history of 52 patients who underwent CXL procedures due to previously diagnosed keratoconus. We reviewed the patient’s medical histories to assess whether there was a herpes labialis infection and/or herpetic keratitis. Altogether, 52 eyes (from 52 patients) were analyzed. Of those, four (7.69%) patients were diagnosed with epithelial herpetic keratitis on the 5–8th day after surgery. All four patients had a history of herpes labialis and no prior HSV keratitis infection. Two patients developed herpetic keratitis despite prophylactic therapy with acyclovir 5 days before surgery. A positive history of HSV lip infection before CXL was present in 18/52 (34.62%). During a one-year follow-up period, no patient experienced a recurrence. Close follow-up is crucial for diagnosing herpetic keratitis after corneal crosslinking. The use of prophylactic antiviral therapy in patients who are asymptomatic and have a history of recurrent herpes labialis does not guarantee the prevention of infection.
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MDPI and ACS Style
Bagatin, F.; Radman, I.; Ranđelović, K.; Petric Vicković, I.; Lacmanović Lončar, V.; Iveković, R.; Vatavuk, Z.
Herpes Simplex Keratitis Following Corneal Crosslinking for Keratoconus: A One-Year Case Series Follow-Up. Diagnostics 2024, 14, 2267.
https://doi.org/10.3390/diagnostics14202267
AMA Style
Bagatin F, Radman I, Ranđelović K, Petric Vicković I, Lacmanović Lončar V, Iveković R, Vatavuk Z.
Herpes Simplex Keratitis Following Corneal Crosslinking for Keratoconus: A One-Year Case Series Follow-Up. Diagnostics. 2024; 14(20):2267.
https://doi.org/10.3390/diagnostics14202267
Chicago/Turabian Style
Bagatin, Freja, Ivana Radman, Karla Ranđelović, Ivanka Petric Vicković, Valentina Lacmanović Lončar, Renata Iveković, and Zoran Vatavuk.
2024. "Herpes Simplex Keratitis Following Corneal Crosslinking for Keratoconus: A One-Year Case Series Follow-Up" Diagnostics 14, no. 20: 2267.
https://doi.org/10.3390/diagnostics14202267
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