Time-Sequential Monitoring of the Early Mesothelial Reaction in the Pleura after Cryoinjury
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animal Preparation
2.2. OCT System
2.3. Thoracic Window
2.4. Cryoinjury to the Pleura
2.5. Hematoxylin and Eosin Staining
3. Results
3.1. Gross Findings of Visceral and Parietal Pleura
3.2. Real-Time In Vivo OCT Image
3.3. Ex Vivo Gross, Histological, and OCT Examination
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parietal Thickening | Visceral Thickening | ||
---|---|---|---|
Pathology | Cryoinjury | 150 ± 8.5 μm | 30 ± 10.5 μm |
Sham | 95 ± 7.6 μm | 13 ± 5.5 μm | |
Normal | 12 ± 3.5 μm | 11 ± 2.5 μm | |
p-Value | 0.02 | 0.04 | |
Ex vivo OCT image | Cryoinjury | 155 ± 10.7 μm | 45 ± 12.5 μm |
Sham | 85 ± 5.5 μm | 14 ± 7.5 μm | |
Normal | 13 ± 2.5 μm | 12 ± 3.5 μm | |
p-Value | 0.03 | 0.04 |
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Kim, T.; Chae, Y.-K.; Nam, S.-J.; Lee, H.; Hwang, S.-S.; Park, E.-K.; Ahn, Y.-C.; Oak, C. Time-Sequential Monitoring of the Early Mesothelial Reaction in the Pleura after Cryoinjury. Diagnostics 2024, 14, 292. https://doi.org/10.3390/diagnostics14030292
Kim T, Chae Y-K, Nam S-J, Lee H, Hwang S-S, Park E-K, Ahn Y-C, Oak C. Time-Sequential Monitoring of the Early Mesothelial Reaction in the Pleura after Cryoinjury. Diagnostics. 2024; 14(3):292. https://doi.org/10.3390/diagnostics14030292
Chicago/Turabian StyleKim, Taeyun, Yu-Kyung Chae, Sung-Jin Nam, Haeyoung Lee, Sang-Suk Hwang, Eun-Kee Park, Yeh-Chan Ahn, and Chulho Oak. 2024. "Time-Sequential Monitoring of the Early Mesothelial Reaction in the Pleura after Cryoinjury" Diagnostics 14, no. 3: 292. https://doi.org/10.3390/diagnostics14030292