A Diagnostic-Driven Prospective Clinical Study Evaluating the Combination of an Antibiofilm Agent and Negative Pressure Wound Therapy
Abstract
:1. Introduction
2. Materials and Methods
3. Results
- Primary Endpoint (wound size):
- Secondary Endpoints:
4. Discussion
5. Limitations
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patient | Age (Years) | Gender | Ulcer Duration (Weeks) | Mini Nutritional Assessment Score | Comorbidities (Major Conditions Listed) |
---|---|---|---|---|---|
1 | 67 | Female | 48 | 7 | Type 2 diabetes, multiple traumas following a motor vehicle accident with paraplegia, permanent colostomy, hypothyroidism, anemia of chronic disease |
2 | 70 | Female | 156 | 7 | Multiple sclerosis with generalized weakness, recent bilateral hip fractures, overactive bladder |
3 | 70 | Male | 68 | 8 | Multiple sclerosis with generalized weakness, wheelchair-bound, obesity |
4 | 46 | - | 58 | 9 | - |
5 | 59 | Female | 20 | 11 | Right above-knee amputation, chronic general body pain |
6 | 22 | Male | 60 | 12 | Paraplegia, muscle spasticity, anemia of chronic disease, neuropathy |
7 | 67 | Female | 52 | 13 | Diabetes, multiple traumas following motor vehicle accident, paraplegia, history of perforated bowel with ileostomy, history of deep venous thrombosis with caval filter hypothyroidism, anemia of chronic disease |
8 | 67 | Male | 8 | 10 | Paraplegia following motor vehicle accident |
9 | 78 | Female | 104 | - | Diabetes, peripheral arterial disease, chronic obstructive pulmonary disease, dysphagia, encephalopathy |
10 | 66 | Female | 36 | 8 | Generalized weakness, dysphagia, coronary artery disease, hypertension, incontinence, schizoaffective disorder, lower extremity contractures, seizure disorder |
11 | 70 | Female | 4 | 14 | Type 2 diabetes, hyperlipidemia, hypothyroidism, hypertension, left breast cancer (resolved) |
12 | 57 | Female | 13 | 14 | Type 2 diabetes, hyperlipidemia, hypertension, obesity, depression |
13 | 80 | Female | 7 | 6 | Hypokalemia, chronic general body pain, constipation |
14 | 68 | Male | 52 | 11 | Hypertension, paraplegia, broken back (4 occasions), chronic general body pain, chronic migraines |
15 | 70 | Male | >52 | 10 | Type 2 diabetes, peripheral vascular disease, lymphedema, hypertension, spinal stenosis, neuropathy, anxiety |
16 | 82 | Male | 12 | 11 | Incontinence, appendectomy, cholecystectomy, back surgery |
17 | 69 | Male | 9 | 12 | Multiple sclerosis, epilepsy, hyperlipidemia, osteoarthritis, vitamin D deficiency, vitamin B12 deficiency |
18 | 82 | Male | 4 | 10 | Type 2 diabetes, atrial fibrillation, hypertension, hypothyroidism, chronic general body pain, iron deficiency anemia |
19 | 49 | Female | 208 | 12 | Type 2 diabetes, paraplegic, hypercholesterolemia, hypertension, multiple back surgeries, urostomy ileal conduit |
20 | 71 | Male | 8 | 7 | Chronic atrial fibrillation, hypertension, benign prostatic hyperplasia, gastroesophageal reflux disease, obesity, depression, COVID-19 |
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Serena, T.E.; King, E.; Serena, L.; Breisinger, K.; Al-Jalodi, O.; Myntti, M.F. A Diagnostic-Driven Prospective Clinical Study Evaluating the Combination of an Antibiofilm Agent and Negative Pressure Wound Therapy. Diagnostics 2024, 14, 774. https://doi.org/10.3390/diagnostics14070774
Serena TE, King E, Serena L, Breisinger K, Al-Jalodi O, Myntti MF. A Diagnostic-Driven Prospective Clinical Study Evaluating the Combination of an Antibiofilm Agent and Negative Pressure Wound Therapy. Diagnostics. 2024; 14(7):774. https://doi.org/10.3390/diagnostics14070774
Chicago/Turabian StyleSerena, Thomas E., Emily King, Laura Serena, Kristy Breisinger, Omar Al-Jalodi, and Matthew F. Myntti. 2024. "A Diagnostic-Driven Prospective Clinical Study Evaluating the Combination of an Antibiofilm Agent and Negative Pressure Wound Therapy" Diagnostics 14, no. 7: 774. https://doi.org/10.3390/diagnostics14070774