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Article

Patlak Slope versus Standardized Uptake Value Image Quality in an Oncologic PET/CT Population: A Prospective Cross-Sectional Study

by
Semra Ince
1,
Richard Laforest
1,
Malak Itani
1,
Vikas Prasad
1,
Saeed Ashrafinia
2,
Anne M. Smith
2,
Richard L. Wahl
1,3 and
Tyler J. Fraum
1,*
1
Department of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd, Campus Box 8131, St. Louis, MO 63110, USA
2
Siemens Medical Solutions USA, Inc., 810 Innovation Drive, Knoxville, TN 37932, USA
3
Department of Radiation Oncology, Washington University School of Medicine, 660 S. Euclid Ave, MSC 8224-35-LL, St. Louis, MO 63110, USA
*
Author to whom correspondence should be addressed.
Diagnostics 2024, 14(9), 883; https://doi.org/10.3390/diagnostics14090883
Submission received: 8 March 2024 / Revised: 12 April 2024 / Accepted: 22 April 2024 / Published: 24 April 2024
(This article belongs to the Special Issue New Trends and Advances of MRI and PET Hybrid Imaging in Diagnostics)
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Abstract

Patlak slope (PS) images have the potential to improve lesion conspicuity compared with standardized uptake value (SUV) images but may be more artifact-prone. This study compared PS versus SUV image quality and hepatic tumor-to-background ratios (TBRs) at matched time points. Early and late SUV and PS images were reconstructed from dynamic positron emission tomography (PET) data. Two independent, blinded readers scored image quality metrics (a four-point Likert scale) and counted tracer-avid lesions. Hepatic lesions and parenchyma were segmented and quantitatively analyzed. Differences were assessed via the Wilcoxon signed-rank test (alpha, 0.05). Forty-three subjects were included. For overall quality and lesion detection, early PS images were significantly inferior to other reconstructions. For overall quality, late PS images (reader 1 [R1]: 3.95, reader 2 [R2]: 3.95) were similar (p > 0.05) to early SUV images (R1: 3.88, R2: 3.84) but slightly superior (p ≤ 0.002) to late SUV images (R1: 2.97, R2: 3.44). For lesion detection, late PS images were slightly inferior to late SUV images (R1 only) but slightly superior to early SUV images (both readers). PS-based TBRs were significantly higher than SUV-based TBRs at the early time point, with opposite findings at the late time point. In conclusion, late PS images are similar to early/late SUV images in image quality and lesion detection; the superiority of SUV versus PS hepatic TBRs is time-dependent.
Keywords: Patlak slope; PET; SUV; metabolic rate; oncology Patlak slope; PET; SUV; metabolic rate; oncology

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MDPI and ACS Style

Ince, S.; Laforest, R.; Itani, M.; Prasad, V.; Ashrafinia, S.; Smith, A.M.; Wahl, R.L.; Fraum, T.J. Patlak Slope versus Standardized Uptake Value Image Quality in an Oncologic PET/CT Population: A Prospective Cross-Sectional Study. Diagnostics 2024, 14, 883. https://doi.org/10.3390/diagnostics14090883

AMA Style

Ince S, Laforest R, Itani M, Prasad V, Ashrafinia S, Smith AM, Wahl RL, Fraum TJ. Patlak Slope versus Standardized Uptake Value Image Quality in an Oncologic PET/CT Population: A Prospective Cross-Sectional Study. Diagnostics. 2024; 14(9):883. https://doi.org/10.3390/diagnostics14090883

Chicago/Turabian Style

Ince, Semra, Richard Laforest, Malak Itani, Vikas Prasad, Saeed Ashrafinia, Anne M. Smith, Richard L. Wahl, and Tyler J. Fraum. 2024. "Patlak Slope versus Standardized Uptake Value Image Quality in an Oncologic PET/CT Population: A Prospective Cross-Sectional Study" Diagnostics 14, no. 9: 883. https://doi.org/10.3390/diagnostics14090883

APA Style

Ince, S., Laforest, R., Itani, M., Prasad, V., Ashrafinia, S., Smith, A. M., Wahl, R. L., & Fraum, T. J. (2024). Patlak Slope versus Standardized Uptake Value Image Quality in an Oncologic PET/CT Population: A Prospective Cross-Sectional Study. Diagnostics, 14(9), 883. https://doi.org/10.3390/diagnostics14090883

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