Analysis of Choriocapillaris Reperfusion Topography following Faricimab Treatment for Neovascular Age-Related Macular Degeneration in Non-Treatment-Naïve Patients
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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MNV Type 1 Eyes (n = 25) | |||
---|---|---|---|
Age (years) | 78.4 ± 6.6 | ||
Gender (female, %) | 17 (68%) | ||
Right eye, n | 12 | ||
injections per eye | 15.9 ± 15.3 | ||
ranibizumab | 13.8 ± 12.8 | ||
aflibercept | 5.1 ± 3.4 | ||
brolucizumab | 10 ± 0 | ||
interval between injections (weeks) | 5.4 ± 1.1 | ||
T0 | T1 | T2 | |
MNV area (mm2) | 0.52 ± 0.12 | 0.48 ± 0.13 p = 0.049 a | 0.49 ± 0.13 p = 0.367 a p = 0.740 b |
BCVA logMAR | 0.50 ± 0.3 | 0.47 ± 0.33 p = 0.58 a | 0.59 ± 0.34 p = 0.46 p = 0.19 |
CC FD (%) T0 | CC FD (%) T1 | CC FD (%) T2 | |
---|---|---|---|
Ring 1 (R1) | 50.5 ± 10.2 | 47.8 ± 11.4 | 46.4 ± 10.6 |
0.362 a | 0.020 a | ||
0.704 b | |||
Ring 2 (R2) | 44.5 ± 9.6 | 42.2 ± 9.2 | 41.7 ± 9.3 |
0.183 a | 0.602 a | ||
0.862 b | |||
Ring 3 (R3) | 39.7 ± 8.6 | 38.9 ± 7.9 | 38.3 ± 7.2 |
0.552 a | 0.739 a | ||
0.615 b | |||
Ring 4 (R4) | 36.9 ± 7.5 | 37.1 ± 7.7 | 35.6 ± 5.6 |
0.881 a | 0.975 a | ||
0.839 b | |||
Ring 5 (R5) | 34.9 ± 6.8 | 35.5 ± 7.5 | 33.3 ± 4.8 |
0.432 a | 0.764 a | ||
0.732 b |
CC FDa T0 | CC FDa T1 | CC FDa T2 | |
---|---|---|---|
Ring 1 (R1) | 140.2 ± 172.1 | 129.5 ± 159.1 | 93.7 ± 101.8 |
0.733 a | 0.029 a | ||
0.411 b | |||
Ring 2 (R2) | 62.6 ± 53.5 | 76.4 ± 17.6 | 49.7 ± 41.5 |
0.665 a | 0.021 a | ||
0.337 b | |||
Ring 3 (R3) | 39.4 ± 26.1 | 37.5 ± 22.1 | 35.1 ± 19.7 |
0.934 a | 0.380 a | ||
0.445 b | |||
Ring 4 (R4) | 30.4 ± 17.5 | 28.7 ± 14.2 | 28.9 ± 12.4 |
0.541 a | 0.919 a | ||
0.481 b | |||
Ring 5 (R5) | 26.2 ± 15.7 | 24.4 ± 11.6 | 26.8 ± 20.8 |
0.279 a | 0.581 a | ||
0.861 b |
CC FDn T0 | CC FDn T1 | CC FDn T2 | |
---|---|---|---|
Ring 1 (R1) | 895.1 ± 1267.4 | 956.5 ± 1421.2 | 1312.7 ± 1363.1 |
0.238 a | 0.067 a | ||
0.386 b | |||
Ring 2 (R2) | 654.3 ± 474.1 | 643.1 ± 505.7 | 833.7 ± 643.3 |
0.254 a | 0.150 a | ||
0.341 b | |||
Ring 3 (R3) | 861.1 ± 537.2 | 886.8 ± 577.9 | 959.1 ± 500.1 |
0.304 a | 0.504 a | ||
0.338 b | |||
Ring 4 (R4) | 1121.2 ± 621.5 | 1159.1 ± 666.1 | 1140.6 ± 506.1 |
0.332 a | 0.862 a | ||
0.334 b | |||
Ring 5 (R5) | 1309.4 ± 588.8 | 1337.3 ± 624.1 | 1263.6 ± 493.1 |
0.343 a | 0.448 a | ||
0.324 b |
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Brinkmann, M.; Viggiano, P.; Boscia, G.; Danckwardt, M.; Susantija, E.; Müller, T.; Castellino, N.; Schweighofer, J.; Boscia, F.; Toro, M.D.; et al. Analysis of Choriocapillaris Reperfusion Topography following Faricimab Treatment for Neovascular Age-Related Macular Degeneration in Non-Treatment-Naïve Patients. Diagnostics 2024, 14, 901. https://doi.org/10.3390/diagnostics14090901
Brinkmann M, Viggiano P, Boscia G, Danckwardt M, Susantija E, Müller T, Castellino N, Schweighofer J, Boscia F, Toro MD, et al. Analysis of Choriocapillaris Reperfusion Topography following Faricimab Treatment for Neovascular Age-Related Macular Degeneration in Non-Treatment-Naïve Patients. Diagnostics. 2024; 14(9):901. https://doi.org/10.3390/diagnostics14090901
Chicago/Turabian StyleBrinkmann, Max, Pasquale Viggiano, Giacomo Boscia, Mathis Danckwardt, Evelyn Susantija, Tom Müller, Niccolò Castellino, Jakob Schweighofer, Francesco Boscia, Mario Damiano Toro, and et al. 2024. "Analysis of Choriocapillaris Reperfusion Topography following Faricimab Treatment for Neovascular Age-Related Macular Degeneration in Non-Treatment-Naïve Patients" Diagnostics 14, no. 9: 901. https://doi.org/10.3390/diagnostics14090901