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Volume 13
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10.3390/jpm13071175
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Review

The Role of Matrix Metalloproteinases in Hemorrhagic Transformation in the Treatment of Stroke with Tissue Plasminogen Activator

by
Valentina A. Babenko
1,
Ksenia S. Fedulova
1,
Denis N. Silachev
1,*,
Parvaneh Rahimi-Moghaddam
2,
Yulia N. Kalyuzhnaya
3,
Svetlana V. Demyanenko
3 and
Egor Y. Plotnikov
1,*
1
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia
2
Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran 14496-14535, Iran
3
Academy of Biology and Biotechnology, Southern Federal University, 344090 Rostov-on-Don, Russia
*
Authors to whom correspondence should be addressed.
J. Pers. Med. 2023, 13(7), 1175; https://doi.org/10.3390/jpm13071175
Submission received: 17 June 2023 / Revised: 15 July 2023 / Accepted: 20 July 2023 / Published: 23 July 2023
(This article belongs to the Special Issue Neurological Diseases: From Molecular Mechanisms to Clinical Practice)
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Abstract

Ischemic stroke is a leading cause of disability and mortality worldwide. The only approved treatment for ischemic stroke is thrombolytic therapy with tissue plasminogen activator (tPA), though this approach often leads to a severe complication: hemorrhagic transformation (HT). The pathophysiology of HT in response to tPA is complex and not fully understood. However, numerous scientific findings suggest that the enzymatic activity and expression of matrix metalloproteinases (MMPs) in brain tissue play a crucial role. In this review article, we summarize the current knowledge of the functioning of various MMPs at different stages of ischemic stroke development and their association with HT. We also discuss the mechanisms that underlie the effect of tPA on MMPs as the main cause of the adverse effects of thrombolytic therapy. Finally, we describe recent research that aimed to develop new strategies to modulate MMP activity to improve the efficacy of thrombolytic therapy. The ultimate goal is to provide more targeted and personalized treatment options for patients with ischemic stroke to minimize complications and improve clinical outcomes.
Keywords: ischemic stroke; thrombolytic therapy; tissue plasminogen activator; hemorrhagic transformation; matrix metalloproteinases ischemic stroke; thrombolytic therapy; tissue plasminogen activator; hemorrhagic transformation; matrix metalloproteinases

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MDPI and ACS Style

Babenko, V.A.; Fedulova, K.S.; Silachev, D.N.; Rahimi-Moghaddam, P.; Kalyuzhnaya, Y.N.; Demyanenko, S.V.; Plotnikov, E.Y. The Role of Matrix Metalloproteinases in Hemorrhagic Transformation in the Treatment of Stroke with Tissue Plasminogen Activator. J. Pers. Med. 2023, 13, 1175. https://doi.org/10.3390/jpm13071175

AMA Style

Babenko VA, Fedulova KS, Silachev DN, Rahimi-Moghaddam P, Kalyuzhnaya YN, Demyanenko SV, Plotnikov EY. The Role of Matrix Metalloproteinases in Hemorrhagic Transformation in the Treatment of Stroke with Tissue Plasminogen Activator. Journal of Personalized Medicine. 2023; 13(7):1175. https://doi.org/10.3390/jpm13071175

Chicago/Turabian Style

Babenko, Valentina A., Ksenia S. Fedulova, Denis N. Silachev, Parvaneh Rahimi-Moghaddam, Yulia N. Kalyuzhnaya, Svetlana V. Demyanenko, and Egor Y. Plotnikov. 2023. "The Role of Matrix Metalloproteinases in Hemorrhagic Transformation in the Treatment of Stroke with Tissue Plasminogen Activator" Journal of Personalized Medicine 13, no. 7: 1175. https://doi.org/10.3390/jpm13071175

APA Style

Babenko, V. A., Fedulova, K. S., Silachev, D. N., Rahimi-Moghaddam, P., Kalyuzhnaya, Y. N., Demyanenko, S. V., & Plotnikov, E. Y. (2023). The Role of Matrix Metalloproteinases in Hemorrhagic Transformation in the Treatment of Stroke with Tissue Plasminogen Activator. Journal of Personalized Medicine, 13(7), 1175. https://doi.org/10.3390/jpm13071175

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