Rethinking Fluid Responsiveness during Septic Shock: Ameliorate Accuracy of Noninvasive Cardiac Output Measurements through Evaluation of Arterial Biomechanical Properties

Papaioannou, Vasileios; Papaioannou, Theodoros

doi:10.3390/jpm14010070

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Rethinking Fluid Responsiveness during Septic Shock: Ameliorate Accuracy of Noninvasive Cardiac Output Measurements through Evaluation of Arterial Biomechanical Properties

by

Vasileios Papaioannou

^1,* and

Theodoros Papaioannou

²

¹

Intensive Care Unit, Alexandroupolis University Hospital, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece

²

Biomedical Engineering and Cardiovascular Mechanics Unit, 1st Department of Cardiology, Hippokration University Hospital, Medical School of the National and Kapodistrian University of Athens, 11527 Athens, Greece

^*

Author to whom correspondence should be addressed.

J. Pers. Med. 2024, 14(1), 70; https://doi.org/10.3390/jpm14010070

Submission received: 22 October 2023 / Revised: 28 December 2023 / Accepted: 4 January 2024 / Published: 5 January 2024

(This article belongs to the Special Issue Personalized Medicine in the ICU)

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Abstract

Beat-to-beat estimates of cardiac output from the direct measure of peripheral arterial blood pressure rely on the assumption that changes in the waveform morphology are related to changes in blood flow and vasomotor tone. However, in septic shock patients, profound changes in vascular tone occur that are not uniform across the entire arterial bed. In such cases, cardiac output estimates might be inaccurate, leading to unreliable evaluation of fluid responsiveness. Pulse wave velocity is the gold-standard method for assessing different arterial biomechanical properties. Such methods might be able to guide, personalize and optimize the management of septic patients.

Keywords: arterial blood pressure; sepsis; fluids; pulse wave velocity; aortic compliance

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MDPI and ACS Style

Papaioannou, V.; Papaioannou, T. Rethinking Fluid Responsiveness during Septic Shock: Ameliorate Accuracy of Noninvasive Cardiac Output Measurements through Evaluation of Arterial Biomechanical Properties. J. Pers. Med. 2024, 14, 70. https://doi.org/10.3390/jpm14010070

AMA Style

Papaioannou V, Papaioannou T. Rethinking Fluid Responsiveness during Septic Shock: Ameliorate Accuracy of Noninvasive Cardiac Output Measurements through Evaluation of Arterial Biomechanical Properties. Journal of Personalized Medicine. 2024; 14(1):70. https://doi.org/10.3390/jpm14010070

Chicago/Turabian Style

Papaioannou, Vasileios, and Theodoros Papaioannou. 2024. "Rethinking Fluid Responsiveness during Septic Shock: Ameliorate Accuracy of Noninvasive Cardiac Output Measurements through Evaluation of Arterial Biomechanical Properties" Journal of Personalized Medicine 14, no. 1: 70. https://doi.org/10.3390/jpm14010070

APA Style

Papaioannou, V., & Papaioannou, T. (2024). Rethinking Fluid Responsiveness during Septic Shock: Ameliorate Accuracy of Noninvasive Cardiac Output Measurements through Evaluation of Arterial Biomechanical Properties. Journal of Personalized Medicine, 14(1), 70. https://doi.org/10.3390/jpm14010070

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Rethinking Fluid Responsiveness during Septic Shock: Ameliorate Accuracy of Noninvasive Cardiac Output Measurements through Evaluation of Arterial Biomechanical Properties

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