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Journal of Personalized Medicine, Volume 14, Issue 1

January 2024 - 126 articles

Cover Story: Treatment with leucovorin (folinic acid), a reduced form of folate, can improve autism spectrum disorder (ASD) symptoms in those positive for folate receptor alpha autoantibodies (FRAAs). To expand on previous research, we studied 110 patients in an ASD clinic who underwent FRAA testing and evaluation with the Social Responsiveness Scale (SRS) and Aberrant Behavior Checklist (ABC). Those positive for soluble folate-binding proteins (sFBPs) had more severe ASD symptoms, and higher binding FRAA titers were associated with greater ABC irritability. Treatment with leucovorin improved most SRS subscales with higher binding FRAA titers associated with greater response. Leucovorin treatment also improved ABC irritability. These results underscore the need for biomarkers to guide the treatment of folate pathways in ASD and suggest that leucovorin may be effective for children with ASD. View this paper
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Articles (126)

  • Review
  • Open Access
16 Citations
6,597 Views
19 Pages

The Impact of Endometriosis on Pregnancy

  • Panagiotis Tsikouras,
  • Efthimios Oikonomou,
  • Anastasia Bothou,
  • Penelopi Chaitidou,
  • Dimitrios Kyriakou,
  • Konstantinos Nikolettos,
  • Sotirios Andreou,
  • Foteini Gaitatzi,
  • Theopi Nalbanti and
  • Panagiotis Peitsidis
  • + 4 authors

22 January 2024

Despite the increased frequency of endometriosis, it remains one of the most enigmatic disorders regarding its effects on pregnancy. Endometriosis adversely affects both natural and assisted conception. Impaired folliculogenesis, which causes follicu...

  • Article
  • Open Access
8 Citations
2,138 Views
12 Pages

22 January 2024

Purpose: The treatment of childhood myopia often involves the use of topical atropine, which has been demonstrated to be effective in decelerating the progression of myopia. It is crucial to monitor intraocular pressure (IOP) to ensure the safety of...

  • Article
  • Open Access
2,655 Views
14 Pages

22 January 2024

Background: Dyslipidemia is a known risk factor for cardiac dysfunction, and lipid-lowering therapy with statins reduces symptoms and reduces hospitalization related to left ventricular heart failure. Acute myocardial infarction (AMI) is a cause of m...

  • Perspective
  • Open Access
5 Citations
3,674 Views
16 Pages

22 January 2024

Dysautonomias are conditions in which altered functions of one or more components of the autonomic nervous system (ANS) adversely affect health. This essay is about how elucidating mechanisms of dysautonomias may rationalize personalized treatments....

  • Article
  • Open Access
10 Citations
3,848 Views
12 Pages

Effects of Intradermal Therapy (Mesotherapy) on Bilateral Cervicobrachial Pain

  • Maurizio Ranieri,
  • Riccardo Marvulli,
  • Eleonora D’Alesio,
  • Mariagrazia Riccardi,
  • Maria Vittoria Raele,
  • Laura Dell’Anna,
  • Annatonia Fai,
  • Giacomo Farì and
  • Marisa Megna

22 January 2024

Background: Mesotherapy is a procedure or a process of injecting drugs into the skin. This technique can help decrease the total drug dose due to its drug-sparing effect on the systemic route and can be utilized to treat nonspecific neck pain that oc...

  • Article
  • Open Access
3 Citations
2,603 Views
18 Pages

The Effectiveness of Adipose Tissue-Derived Mesenchymal Stem Cells Mixed with Platelet-Rich Plasma in the Healing of Inflammatory Bowel Anastomoses: A Pre-Clinical Study in Rats

  • Georgios Geropoulos,
  • Kyriakos Psarras,
  • Maria Papaioannou,
  • Vasileios Geropoulos,
  • Argyri Niti,
  • Christina Nikolaidou,
  • Georgios Koimtzis,
  • Nikolaos Symeonidis,
  • Efstathios T. Pavlidis and
  • Georgios Koliakos
  • + 2 authors

22 January 2024

Introduction: Multiple factors have been linked with increased risk of anastomotic leak in bowel surgery, including infections, inflammatory bowel disease, patient comorbidities and poor surgical technique. The aim of this study was to investigate th...

  • Article
  • Open Access
2,279 Views
16 Pages

20 January 2024

Accurate minimally invasive anatomic liver (sub)segmentectomy (MIAS) is technically demanding and not yet standardized, and its surgical outcomes are undefined. To study the impact of the minimally invasive approach on perioperative outcomes of anato...

  • Review
  • Open Access
6 Citations
9,321 Views
20 Pages

Vitamin D—The Iceberg in Endometriosis—Review and Meta-Analysis

  • Alexandra Ursache,
  • Ludmila Lozneanu,
  • Iuliana Elena Bujor,
  • Cristina Elena Mandici,
  • Lucian Vasile Boiculese,
  • Alexandra Irma Gabriela Bausic,
  • Mihaela Grigore,
  • Demetra Socolov and
  • Daniela Roxana Matasariu

20 January 2024

(1) Background: Although vitamin D has many known biological effects, very little research has been conducted on how vitamin D may be related or play a role in endometriosis. The aim of our study was to perform an evaluation regarding vitamin D level...

  • Review
  • Open Access
15 Citations
6,356 Views
12 Pages

The Reciprocal Relationship between Sleep and Epilepsy

  • Yana Krutoshinskaya,
  • Kelly Coulehan,
  • Galyna Pushchinska and
  • Rebecca Spiegel

20 January 2024

The relationship between sleep and epilepsy is bidirectional. Certain epilepsy syndromes predominantly or exclusively manifest during sleep, with seizures frequently originating from non-rapid eye movement (NREM) sleep. Interictal epileptiform discha...

  • Article
  • Open Access
3 Citations
2,027 Views
10 Pages

20 January 2024

Lung cancer is the leading cause of cancer-related deaths among both men and women. African Americans (AAs) experience disproportionately higher incidence and mortality compared to other ethnic groups. Cytokines play multifaceted and crucial roles in...

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J. Pers. Med. - ISSN 2075-4426