General Anesthesia Improves Efficiency of High-Power Short-Duration Catheter Ablation for Atrial Fibrillation: Comparison with Mild Conscious Sedation
Abstract
:1. Introduction
2. Method
2.1. Patient Population
2.2. Ablation Procedure
2.3. Anesthesia Protocol
2.4. Follow-Up
2.5. Statistical Analysis
3. Results
4. Discussion
5. Study Limitations
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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GROUP 1 (n = 47) | GROUP 2 (n = 84) | p-Value | |
---|---|---|---|
Age (years old) | 58.6 ± 10.6 | 60.2 ± 10.2 | 0.41 |
Gender (males, N, %) | 32 (68%) | 55 (65.4%) | 0.76 |
Type of AF (paroxysmal, N, %) | 34 (72.3%) | 68 (80.9%) | 0.26 |
Left atrial diameter (mm) | 41.5 ± 5.7 | 40.2 ± 10.2 | 0.15 |
Radiation exposure dosis (μGy) | 932.5 [625–1716] | 2445 [1228–4791] | <0.0001 |
Radiation exposure time (min) | 4.5 [3–7.1] | 7.3 [4.2–13.5] | 0.0003 |
Procedure time (min) | 100 [90–120] | 160 [130–180] | <0.0001 |
Number of RF applications | 71 [54.8–83.8] | 103 [88.5–120.5] | <0.0001 |
Antiarrhythmic drugs, N (%) | |||
Amiodarone | 20 (42.6) | 36 (42.9) | 0.97 |
Propafenone | 5 (10.6) | 18 (21.4) | 0.13 |
Flecainide | 20 (42.6) | 29 (34.5) | 0.36 |
Hypertension | 27 (57.4) | 60 (71.4) | 0.11 |
Diabetes mellitus | 9 (19.1) | 14 (16.7) | 0.72 |
Ischemic heart disease | 6 (12.8) | 12 (14.3) | 0.81 |
Heart failure | 8 (17) | 11 (13.1) | 0.54 |
Mitral regurgitation | 4 (8.5) | 14 (16.7) | 0.20 |
Obesity | 11 (23.4) | 23 (27.4) | 0.62 |
COPD | 3 (6.4) | 6 (7.1) | 0.87 |
Chronic kidney disease | 0 (0) | 2 (2.4) | 0.29 |
6-month AF recurrence rate, N (%) | 10 (21.3) | 28 (33.3) | 0.15 |
Variable | OR | 95%CI | p |
---|---|---|---|
Use of GA | 0.55 | 0.24 to 1.24 | 0.15 |
Left atrial diameter (mm) | 1.18 | 1.08 to 1.28 | 0.0003 |
Number of RF applications | 1.01 | 1.0009 to 1.03 | 0.03 |
Persistent AF | 4.47 | 1.87 to 10.69 | 0.0007 |
Amiodarone | 2.05 | 0.95 to 4.40 | 0.07 |
Propafenone | 0.46 | 0.15 to 1.45 | 0.18 |
Flecainide | 0.82 | 0.37 to 1.81 | 0.63 |
Hypertension | 1.94 | 0.82 to 4.58 | 0.13 |
Mitral regurgitation | 3.79 | 1.36 to 10.56 | 0.01 |
OR | 95%CI | p | |
---|---|---|---|
All patients | |||
Use of GA | 0.57 | 0.19 to 1.70 | 0.31 |
Left atrial diameter (mm) | 1.09 | 0.99 to 1.21 | 0.09 |
Number of RF applications | 1.001 | 0.98 to 1.02 | 0.88 |
Persistent AF | 3.33 | 1.19 to 9.32 | 0.02 |
Mitral regurgitation | 2.42 | 0.76 to 7.66 | 0.13 |
Paroxysmal AF | |||
Use of GA | 0.34 | 0.08 to 1.50 | 0.16 |
Left atrial diameter (mm) | 1.17 | 1.03 to 1.33 | 0.01 |
Number of RF applications | 0.99 | 0.97 to 1.01 | 0.49 |
Mitral regurgitation | 3.49 | 0.94 to 12.96 | 0.06 |
Persistent AF | |||
Use of GA | 0.80 | 0.13 to 4.82 | 0.81 |
Left atrial diameter (mm) | 0.91 | 0.72 to 1.15 | 0.44 |
Number of RF applications | 1.02 | 0.99 to 1.05 | 0.21 |
Mitral regurgitation | 1.67 | 0.17 to 16.14 | 0.66 |
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Minciună, I.-A.; Tomoaia, R.; Suceveanu, M.; Cismaru, G.; Puiu, M.; Roșu, R.; Simu, G.; Irimie, D.A.; Frîngu, F.; Caloian, B.; et al. General Anesthesia Improves Efficiency of High-Power Short-Duration Catheter Ablation for Atrial Fibrillation: Comparison with Mild Conscious Sedation. J. Pers. Med. 2024, 14, 865. https://doi.org/10.3390/jpm14080865
Minciună I-A, Tomoaia R, Suceveanu M, Cismaru G, Puiu M, Roșu R, Simu G, Irimie DA, Frîngu F, Caloian B, et al. General Anesthesia Improves Efficiency of High-Power Short-Duration Catheter Ablation for Atrial Fibrillation: Comparison with Mild Conscious Sedation. Journal of Personalized Medicine. 2024; 14(8):865. https://doi.org/10.3390/jpm14080865
Chicago/Turabian StyleMinciună, Ioan-Alexandru, Raluca Tomoaia, Mihai Suceveanu, Gabriel Cismaru, Mihai Puiu, Radu Roșu, Gelu Simu, Diana Andrada Irimie, Florina Frîngu, Bogdan Caloian, and et al. 2024. "General Anesthesia Improves Efficiency of High-Power Short-Duration Catheter Ablation for Atrial Fibrillation: Comparison with Mild Conscious Sedation" Journal of Personalized Medicine 14, no. 8: 865. https://doi.org/10.3390/jpm14080865