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Advancing the Diagnosis of Diabetic Neuropathies: Electrodiagnostic and Skin Autofluorescence Methods
by
Dan Trofin
Dan Trofin 1,2,
Bianca-Margareta Salmen
Bianca-Margareta Salmen 3
,
Teodor Salmen
Teodor Salmen 3,*
,
Daniela Marilena Trofin
Daniela Marilena Trofin 4 and
Delia Reurean-Pintilei
Delia Reurean-Pintilei 1,5
1
Department of Diabetes, Nutrition and Metabolic Diseases, Consultmed Medical Centre, 700544 Iasi, Romania
2
Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, 700454 Iasi, Romania
3
Doctoral School of Carol Davila, University of Medicine and Pharmacy, 020021 Bucharest, Romania
4
Neurology Clinic, The Rehabilitation Hospital, 700661 Iasi, Romania
5
Department of Medical-Surgical and Complementary Sciences, Faculty of Medicine and Biological Sciences, “Ștefan cel Mare” University, 720229 Suceava, Romania
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2024, 14(8), 884; https://doi.org/10.3390/jpm14080884 (registering DOI)
Submission received: 2 August 2024
/
Revised: 17 August 2024
/
Accepted: 19 August 2024
/
Published: 21 August 2024
Abstract
Introduction: Diabetic neuropathy (DN) is a generic term for various neuropathies coexisting in a single patient. Clinical diagnosis alone can be misleading, yet routine electrodiagnostic studies in diabetes care are rare. Skin autofluorescence (SAF) is a recognized DN risk factor with potential screening value. This article highlights the diagnostic challenges and raises awareness of the often underdiagnosed neuropathic conditions in diabetes patients. Material and Methods: We present common entrapment neuropathy cases from our diabetes clinic’s electrodiagnosis laboratory in Iași, Romania. We selected seven type 2 diabetes patients with sensory or sensory-motor distal polyneuropathy and atypical DN presentations investigated through electroneurography (ENG) and electromyography (EMG) with the Neurosoft® EMG instrument and SAF measured by standard procedures. Subsequently, a narrative literature review was conducted. Results: Entrapment neuropathies were diagnosed in all the patients: three carpal tunnel syndromes, two ulnar neuropathies (one proximal, one distal), one peroneal neuropathy, and one case of meralgia paresthetica. The lower-limb cases showed radiculoplexopathy, and there was one case of superficial radial nerve neuropathy. The SAF values ranged from 2.5 AU to 3.4 AU. Conclusion: Electrodiagnosis is essential for detecting focal neuropathies in patients with sensory-motor distal polyneuropathy. Elevated SAF levels may correlate with symptom severity, although further research, including large cohorts, is needed.
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MDPI and ACS Style
Trofin, D.; Salmen, B.-M.; Salmen, T.; Trofin, D.M.; Reurean-Pintilei, D.
Advancing the Diagnosis of Diabetic Neuropathies: Electrodiagnostic and Skin Autofluorescence Methods. J. Pers. Med. 2024, 14, 884.
https://doi.org/10.3390/jpm14080884
AMA Style
Trofin D, Salmen B-M, Salmen T, Trofin DM, Reurean-Pintilei D.
Advancing the Diagnosis of Diabetic Neuropathies: Electrodiagnostic and Skin Autofluorescence Methods. Journal of Personalized Medicine. 2024; 14(8):884.
https://doi.org/10.3390/jpm14080884
Chicago/Turabian Style
Trofin, Dan, Bianca-Margareta Salmen, Teodor Salmen, Daniela Marilena Trofin, and Delia Reurean-Pintilei.
2024. "Advancing the Diagnosis of Diabetic Neuropathies: Electrodiagnostic and Skin Autofluorescence Methods" Journal of Personalized Medicine 14, no. 8: 884.
https://doi.org/10.3390/jpm14080884
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