Next Article in Journal
Coxiella burnetii in Dogs and Cats from Portugal: Serological and Molecular Analysis
Previous Article in Journal
Linguatula serrata (Fröhlich, 1789) in Gray Wolf (Canis lupus) from Italy: A Neglected Zoonotic Parasite
Previous Article in Special Issue
Efficacy and Safety of Bulevirtide plus Tenofovir Disoproxil Fumarate in Real-World Patients with Chronic Hepatitis B and D Co-Infection
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pathogens
Volume 11
Issue 12
10.3390/pathogens11121524
pathogens-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Low Risk of Occult Hepatitis B Infection among Vietnamese Blood Donors

by
Tran Thanh Tung
1,2,†,
Jürgen Schmid
1,†,
Vu Xuan Nghia
3,†,
Le Chi Cao
1,4,
Le Thi Kieu Linh
1,2,
Ikrormi Rungsung
1,
Bui Tien Sy
1,3,
Truong Nhat My
2,
Nguyen Trong The
2,3,
Nghiem Xuan Hoan
2,3,
Christian G. Meyer
1,2,
Heiner Wedemeyer
5,6,
Peter G. Kremsner
1,7,
Nguyen Linh Toan
8,
Le Huu Song
2,3,‡,
C.-Thomas Bock
1,9,*,‡ and
Thirumalaisamy P. Velavan
1,2,‡
1
Institute of Tropical Medicine, University of Tübingen, 72074 Tübingen, Germany
2
Vietnamese-German Center for Medical Research (VG-CARE), Hanoi 10000, Vietnam
3
108 Military Central Hospital, Hanoi 10000, Vietnam
4
Department of Parasitology, Hue University of Medicine and Pharmacy (HUMP), Hue 52000, Vietnam
5
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30623 Hannover, Germany
6
German Center for Infection Research, Partner Hannover-Braunschweig, 38104 Braunschweig, Germany
7
Centre de Recherches Medicales de Lambarene, Lambaréné B.P. 242, Gabon
8
Department of Pathophysiology, Vietnam Military Medical University, Hanoi 10000, Vietnam
9
Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch Institute, 13353 Berlin, Germany
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to the work.
‡
Shared senior authors.
Pathogens 2022, 11(12), 1524; https://doi.org/10.3390/pathogens11121524
Submission received: 21 November 2022 / Revised: 8 December 2022 / Accepted: 9 December 2022 / Published: 13 December 2022
(This article belongs to the Special Issue Molecular Epidemiology, Host Genetic Factors, and Viral Hepatitis Related Liver Diseases)
Browse Figures
Versions Notes

Abstract

Occult hepatitis B infection (OBI) is characterized by the presence of low levels of hepatitis B virus (HBV) DNA and undetectable HBsAg in the blood. The prevalence of OBI in blood donors in Asia ranges from 0.013% (China) to 10.9% (Laos), with no data available from Vietnam so far. We aimed to investigate the prevalence of OBI among Vietnamese blood donors. A total of 623 (114 women and 509 men) HBsAg-negative blood donors were screened for anti-HBc and anti-HBs by ELISA assays. In addition, DNA from sera was isolated and nested PCR was performed for the HBV surface gene (S); a fragment of the S gene was then sequenced in positive samples. The results revealed that 39% (n = 242) of blood donors were positive for anti-HBc, and 70% (n = 434) were positive for anti-HBs, with 36% (n = 223) being positive for both anti-HBc and anti-HBs. In addition, 3% of blood donors (n = 19) were positive for anti-HBc only, and 34% (n = 211) had only anti-HBs as serological marker. A total of 27% (n = 170) were seronegative for any marker. Two of the blood donors (0.3%) were OBI-positive and sequencing revealed that HBV sequences belonged to HBV genotype B, which is the predominant genotype in Vietnam.
Keywords: occult hepatitis B; hepatitis B virus; Vietnam; blood donors; hepatitis B surface antigen occult hepatitis B; hepatitis B virus; Vietnam; blood donors; hepatitis B surface antigen

Share and Cite

MDPI and ACS Style

Tung, T.T.; Schmid, J.; Nghia, V.X.; Cao, L.C.; Linh, L.T.K.; Rungsung, I.; Sy, B.T.; My, T.N.; The, N.T.; Hoan, N.X.; et al. Low Risk of Occult Hepatitis B Infection among Vietnamese Blood Donors. Pathogens 2022, 11, 1524. https://doi.org/10.3390/pathogens11121524

AMA Style

Tung TT, Schmid J, Nghia VX, Cao LC, Linh LTK, Rungsung I, Sy BT, My TN, The NT, Hoan NX, et al. Low Risk of Occult Hepatitis B Infection among Vietnamese Blood Donors. Pathogens. 2022; 11(12):1524. https://doi.org/10.3390/pathogens11121524

Chicago/Turabian Style

Tung, Tran Thanh, Jürgen Schmid, Vu Xuan Nghia, Le Chi Cao, Le Thi Kieu Linh, Ikrormi Rungsung, Bui Tien Sy, Truong Nhat My, Nguyen Trong The, Nghiem Xuan Hoan, and et al. 2022. "Low Risk of Occult Hepatitis B Infection among Vietnamese Blood Donors" Pathogens 11, no. 12: 1524. https://doi.org/10.3390/pathogens11121524

APA Style

Tung, T. T., Schmid, J., Nghia, V. X., Cao, L. C., Linh, L. T. K., Rungsung, I., Sy, B. T., My, T. N., The, N. T., Hoan, N. X., Meyer, C. G., Wedemeyer, H., Kremsner, P. G., Toan, N. L., Song, L. H., Bock, C.-T., & Velavan, T. P. (2022). Low Risk of Occult Hepatitis B Infection among Vietnamese Blood Donors. Pathogens, 11(12), 1524. https://doi.org/10.3390/pathogens11121524

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop