The Skin Microbiome in Cutaneous T-Cell Lymphomas (CTCL)—A Narrative Review

Round 1

Reviewer 1 Report

Thank you for this nice review of the current available data on the microbiome of CTCL. The mentioning of Cutavirus is great, it's a promising topic in CTCL pathogenesis.

Author Response

Dear Reviewer,

We are very thankful for your precious time spent reviewing our manuscript. We appreciate your kind words and are very glad that you enjoyed our review, considering the role of the skin microbiome in CTCL.

Reviewer 2 Report

It is an interesting review discussing the link between skin microbiome and cutaneous T-cell lymphomas (CTCL).  The review includes the following points:

a) Healthy skin microbiome.  b)The role of the microbes in skin diseases development and progression.    c)The skin microbiome and role of microorganisms in CTCL  including mainly the roles of Staph aureus and Cutavirus.   d)Therapeutic approaches in CTCL and their influence on the skin microbiome including Skin-directed therapy and antibiotics

e) Future directions

I have some suggestions

1- The review need careful language editing and to be revised by a native language speaker before resubmission

2- In the title "3. The role of the microbes in skin diseases development and progression". I suggest to make subtitles as 3.1 , 3.2 and each one include a specific skin disease as atopic dermatitis ,.. etc.

3- For Figure 1: is it designed by the authors? if yes, please mention the software/program used.

4- title :5.2. Antibiotics in CTCL:, since most literatures of this topic are focused or S. aureus infection.  I suggest to rephrase  it " Effect of antibiotics on S.aureus associated  with CTCL.

5- Under the title 4; I suggest include the role of other bacteria such as S.epidermidis and its products such as cysteine protease and lantibiotics.

Author Response

Dear Reviewer,

We are very thankful for your precious time spent reviewing our manuscript and all your valuable comments and suggestions. A point-by-point response is provided in the attachment. You can find all changes in the updated manuscript version using the “Track Changes” function. Please see the attachment. 

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

no further comments