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Pathogens
Volume 12
Issue 8
10.3390/pathogens12080990
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Article
Peer-Review Record

Latent Tuberculosis Infection and Associated Risk Factors among People Living with HIV and HIV-Uninfected Individuals in Lithuania

Pathogens 2023, 12(8), 990; https://doi.org/10.3390/pathogens12080990
by Elzbieta Matulyte 1,*, Zavinta Kancauskiene 2, Aidas Kausas 3, Jurgita Urboniene 4, Vilnele Lipnickiene 5, Jelena Kopeykiniene 6, Tomas Gudaitis 7, Sarunas Raudonis 7, Edvardas Danila 8,9, Dominique Costagliola 10 and Raimonda Matulionyte 1
Pathogens 2023, 12(8), 990; https://doi.org/10.3390/pathogens12080990
Submission received: 21 June 2023 / Revised: 20 July 2023 / Accepted: 26 July 2023 / Published: 28 July 2023
(This article belongs to the Special Issue Tuberculosis and Nontuberculous Mycobacterial Infections in the Immunocompromised Host)

Round 1

Reviewer 1 Report

It is a study on a cross-sectional study was conducted from August 2018 to May 2022 in three geographically distinct Infectious diseases departments/centres – Vilnius University Hospital Santaros Klinikos, Republican Siauliai County Hospital and Klaipeda University Hospital – providing the vast majority of primary, outpatient and inpatient care to PLHIV in Lithuania. This study compared LTBI prevalence in PLHIV and risk factors associated with LTBI in a country with a low incidence of HIV, intermediate prevalence of TB, and a high BCG vaccination coverage.

It is a work of importance in public health, demonstrating that the prevalence of LTBI defined by positive IGRA and/or TST among PLHIV was higher compared to HIV-uninfected population: 20.5% vs. 11.1%. This fact emphasizes the need of treatment of LTBI in this population.

 

Lines 64 and 292 show an error in the formatting of references: "Reference Source Not Found".

Please make corrections before submitting the final version.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Attached 

Comments for author File: Comments.pdf

·         English edits required throughout the manuscript. Few examples of improperly formed sentences:

·         Line 297-298: “Within our study population, PLHIV were less likely to have a positive TST than HIV-uninfected persons even significant association has not been found.”

·         Line 313-314: “In our study the discordant results of QFT-GIT and TST led to only a fair agreement between the two tests among PLHIV and a slight agreement in HIV-negative population.”

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

The authors have addressed the comments satisfactorily.

Quality has improved

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