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Volume 13
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10.3390/pathogens13100846
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Article

Frequency of Group A Streptococcus Infection and Analysis of Antibiotic Use in Patients with Pharyngitis—A Retrospective, Multicenter Study

by
Martyna Biała
1,*,
Mateusz Babicki
2,
Wojciech Malchrzak
2,
Sandra Janiak
3,
Dominik Gajowiak
4,
Alan Żak
5,
Karolina Kłoda
6,
Piotr Gibas
7,
Justyna Ledwoch
8,
Anna Myśliwiec
9,
Daria Kopyt
10,
Anna Węgrzyn
11,
Brygida Knysz
1 and
Patrycja Leśnik
12
1
Department of Infectious Diseases, Liver Diseases and Acquired Immune Deficiences, Wroclaw Medical University, 51-149 Wroclaw, Poland
2
Department of Family Medicine, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland
3
Department of Family Medicine, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, 85-094 Bydgoszcz, Poland
4
Indywidualna Praktyka Lekarska Dominik Gajowiak, 62-420 Radlowo, Poland
5
Centrum Medyczne AD-Med. ul. Syrokomli 1, 51-141 Wroclaw, Poland
6
MEDFIT Karolina Kłoda, ul. Narutowicza 13E/11, 70-240 Szczecin, Poland
7
NZOZ NOWA-MED., 34-100 Wadowice, Poland
8
NZOZ Kraków Południe, 30-315 Kraków, Poland
9
SZPZLO Warszawa-Wawer, 04-564 Warszawa, Poland
10
NZOZ Przychodnia Wassowskiego, 80-225 Gdańsk, Poland
11
Poradnia Medycyny Rodzinnej S.C. NZOZ Łapanów 186, 32-740 Łapanów, Poland
12
Department of Microbiology, Wroclaw Medical University, 50-368 Wroclaw, Poland
 
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*
Author to whom correspondence should be addressed.
Pathogens 2024, 13(10), 846; https://doi.org/10.3390/pathogens13100846
Submission received: 15 August 2024 / Revised: 31 August 2024 / Accepted: 27 September 2024 / Published: 28 September 2024
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Abstract

Streptococcus pyogenes is responsible for 20–30% of pharyngitis in children and 5–15% in adults. The ineffective treatment of group A Streptococcus (GAS) infections can result in postinfectious sequelae. This study aims to evaluate the frequency of GAS pharyngitis and assess the management of patients with pharyngitis and antibiotic use. We conducted a multicenter, retrospective analysis of medical records from nine primary care centers in Poland. The study enrolled 1949 medical records of patients (children 67.4%, adults 32.6%). An infection of Streptococcus pyogenes, based on a rapid strep test, was diagnosed in 830 patients (42.6%). In the comprehensive study group of 1949 patients, 1054 (54.1%) were given antibiotics. Notably, 224 patients had a negative rapid strep test result but still received antibiotic treatment, underscoring the complexity of treatment decisions. The most commonly used antibiotics were oral penicillin V in 431 cases (41%) and amoxicillin in 219 cases (20.8%). We observed no significant difference between positive rapid strep test results and patients’ sociodemographic data and comorbidities. The prevalence of GAS was 42.6% in the analyzed records of patients with pharyngitis, and 54.1% were prescribed antibiotics. Antibiotics were overprescribed for sore throats. Strategies are needed to promote rational antibiotic use.
Keywords: Streptococcus pyogenes; GAS; infection; antibiotics Streptococcus pyogenes; GAS; infection; antibiotics

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MDPI and ACS Style

Biała, M.; Babicki, M.; Malchrzak, W.; Janiak, S.; Gajowiak, D.; Żak, A.; Kłoda, K.; Gibas, P.; Ledwoch, J.; Myśliwiec, A.; et al. Frequency of Group A Streptococcus Infection and Analysis of Antibiotic Use in Patients with Pharyngitis—A Retrospective, Multicenter Study. Pathogens 2024, 13, 846. https://doi.org/10.3390/pathogens13100846

AMA Style

Biała M, Babicki M, Malchrzak W, Janiak S, Gajowiak D, Żak A, Kłoda K, Gibas P, Ledwoch J, Myśliwiec A, et al. Frequency of Group A Streptococcus Infection and Analysis of Antibiotic Use in Patients with Pharyngitis—A Retrospective, Multicenter Study. Pathogens. 2024; 13(10):846. https://doi.org/10.3390/pathogens13100846

Chicago/Turabian Style

Biała, Martyna, Mateusz Babicki, Wojciech Malchrzak, Sandra Janiak, Dominik Gajowiak, Alan Żak, Karolina Kłoda, Piotr Gibas, Justyna Ledwoch, Anna Myśliwiec, and et al. 2024. "Frequency of Group A Streptococcus Infection and Analysis of Antibiotic Use in Patients with Pharyngitis—A Retrospective, Multicenter Study" Pathogens 13, no. 10: 846. https://doi.org/10.3390/pathogens13100846

APA Style

Biała, M., Babicki, M., Malchrzak, W., Janiak, S., Gajowiak, D., Żak, A., Kłoda, K., Gibas, P., Ledwoch, J., Myśliwiec, A., Kopyt, D., Węgrzyn, A., Knysz, B., & Leśnik, P. (2024). Frequency of Group A Streptococcus Infection and Analysis of Antibiotic Use in Patients with Pharyngitis—A Retrospective, Multicenter Study. Pathogens, 13(10), 846. https://doi.org/10.3390/pathogens13100846

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