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Volume 13
Issue 9
10.3390/pathogens13090729
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Article

First Trial of a Novel Caseous Lymphadenitis Inactivated Vaccine in South Korea: Experimental Evaluation across Various Animal Models

by
Gyeong-Seo Park
1,
Somin Lee
1,
Min A Jeong
1,
So Young Lee
1,
Dong-Geun Cho
2,
WonIl Cho
2,
Seung-Chai Kim
3,
Hwan-Ju Kim
3,
Taek Geun Lee
3,
Chang-Gi Jeong
3,
Won-Il Kim
3,
Yeonsu Oh
4,
Ho-Seong Cho
3,*,
Byoung-Joo Seo
1,* and
Chonghan Kim
1,*
1
Vaccine Lab, WOOGENE B&G Co., Ltd., Seoul 07299, Republic of Korea
2
Osan Black Goat Farm, Gokseong 57518, Republic of Korea
3
College of Veterinary Medicine, Bio-Safety Research Institute, Jeonbuk National University, Iksan 54596, Republic of Korea
4
College of Veterinary Medicine and Institute of Veterinary Science, Kwangwon National University, Chuncheon 24341, Republic of Korea
*
Authors to whom correspondence should be addressed.
Pathogens 2024, 13(9), 729; https://doi.org/10.3390/pathogens13090729
Submission received: 17 July 2024 / Revised: 23 August 2024 / Accepted: 23 August 2024 / Published: 28 August 2024
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Abstract

Caseous lymphadenitis (CLA) is a chronic and subclinical bacterial disease of ruminants caused by Corynebacterium pseudotuberculosis (C. pseudotuberculosis) infection. Until 2014, there were no reports of CLA outbreaks in South Korea; however, the prevalence of CLA cases has steadily increased. In this study, we used recently obtained field isolates to develop the first inactivated CLA vaccine in South Korea and evaluated it in various animal models. The inactivated vaccine was evaluated for virulence and effectiveness. Mice were tested for virulence and immunization challenges, and guinea pigs and Korean Native Black Goats (KNBGs) evaluated various vaccine concentrations to determine the optimal dose and effectiveness. In the case of KNBGs, clinical symptoms were not observed after vaccination. In addition, CLA-specific IgG was detected at a significantly (p < 0.05) high level and was maintained. In histopathological evaluations, inflammation was predominantly observed in the prefemoral lymph nodes in the non-vaccinated+CHAL group. The genetic diversity of C. pseudotuberculosis, which has become widespread in South Korea, is less than 0.5% our vaccine is expected to prevent infection by a wide range of strains effectively. In summary, our CLA vaccine can potentially prevent CLA and foster the growth of South Korea’s domestic KNBG industry.
Keywords: Corynebacterium pseudotuberculosis; Korean Native Black Goats (KNBGs); Caseous Lymphadenitis (CLA); inactivated vaccine; animal trials Corynebacterium pseudotuberculosis; Korean Native Black Goats (KNBGs); Caseous Lymphadenitis (CLA); inactivated vaccine; animal trials

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MDPI and ACS Style

Park, G.-S.; Lee, S.; Jeong, M.A.; Lee, S.Y.; Cho, D.-G.; Cho, W.; Kim, S.-C.; Kim, H.-J.; Lee, T.G.; Jeong, C.-G.; et al. First Trial of a Novel Caseous Lymphadenitis Inactivated Vaccine in South Korea: Experimental Evaluation across Various Animal Models. Pathogens 2024, 13, 729. https://doi.org/10.3390/pathogens13090729

AMA Style

Park G-S, Lee S, Jeong MA, Lee SY, Cho D-G, Cho W, Kim S-C, Kim H-J, Lee TG, Jeong C-G, et al. First Trial of a Novel Caseous Lymphadenitis Inactivated Vaccine in South Korea: Experimental Evaluation across Various Animal Models. Pathogens. 2024; 13(9):729. https://doi.org/10.3390/pathogens13090729

Chicago/Turabian Style

Park, Gyeong-Seo, Somin Lee, Min A Jeong, So Young Lee, Dong-Geun Cho, WonIl Cho, Seung-Chai Kim, Hwan-Ju Kim, Taek Geun Lee, Chang-Gi Jeong, and et al. 2024. "First Trial of a Novel Caseous Lymphadenitis Inactivated Vaccine in South Korea: Experimental Evaluation across Various Animal Models" Pathogens 13, no. 9: 729. https://doi.org/10.3390/pathogens13090729

APA Style

Park, G.-S., Lee, S., Jeong, M. A., Lee, S. Y., Cho, D.-G., Cho, W., Kim, S.-C., Kim, H.-J., Lee, T. G., Jeong, C.-G., Kim, W.-I., Oh, Y., Cho, H.-S., Seo, B.-J., & Kim, C. (2024). First Trial of a Novel Caseous Lymphadenitis Inactivated Vaccine in South Korea: Experimental Evaluation across Various Animal Models. Pathogens, 13(9), 729. https://doi.org/10.3390/pathogens13090729

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