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Microorganisms
Volume 10
Issue 3
10.3390/microorganisms10030501
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Perspective

Innate Immune Response in SARS-CoV-2 Infection

by
Giovanna Schiuma
†,
Silvia Beltrami
†,
Daria Bortolotti
*,
Sabrina Rizzo
‡ and
Roberta Rizzo
‡
Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy
*
Author to whom correspondence should be addressed.
†
These authors contribute equally to this work.
‡
These authors contribute equally to this work.
Microorganisms 2022, 10(3), 501; https://doi.org/10.3390/microorganisms10030501
Submission received: 10 December 2021 / Revised: 21 February 2022 / Accepted: 22 February 2022 / Published: 23 February 2022
(This article belongs to the Section Virology)
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Abstract

An efficient host immune response is crucial in controlling viral infections. Despite most studies focused on the implication of T and B cell response in COVID-19 (Corona Virus Disease-19) patients or in their activation after vaccination against SARS-CoV-2, host innate immune response has raised even more interest as well. In fact, innate immunity, including Natural Killer (NK) cells, monocytes/macrophages and neutrophils, represent the first line of defense against the virus and it is essential to determine the correct activation of an efficient and specific acquired immune response. In this perspective, we will report an overview on the main findings concerning SARS-CoV-2 interaction with innate host immune system, in correlation with pathogenesis and viral immune escape mechanisms.
Keywords: SARS-CoV-2; immunity; innate immune cells; immune-evasion; natural killer cells SARS-CoV-2; immunity; innate immune cells; immune-evasion; natural killer cells

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MDPI and ACS Style

Schiuma, G.; Beltrami, S.; Bortolotti, D.; Rizzo, S.; Rizzo, R. Innate Immune Response in SARS-CoV-2 Infection. Microorganisms 2022, 10, 501. https://doi.org/10.3390/microorganisms10030501

AMA Style

Schiuma G, Beltrami S, Bortolotti D, Rizzo S, Rizzo R. Innate Immune Response in SARS-CoV-2 Infection. Microorganisms. 2022; 10(3):501. https://doi.org/10.3390/microorganisms10030501

Chicago/Turabian Style

Schiuma, Giovanna, Silvia Beltrami, Daria Bortolotti, Sabrina Rizzo, and Roberta Rizzo. 2022. "Innate Immune Response in SARS-CoV-2 Infection" Microorganisms 10, no. 3: 501. https://doi.org/10.3390/microorganisms10030501

APA Style

Schiuma, G., Beltrami, S., Bortolotti, D., Rizzo, S., & Rizzo, R. (2022). Innate Immune Response in SARS-CoV-2 Infection. Microorganisms, 10(3), 501. https://doi.org/10.3390/microorganisms10030501

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