Relationship between the Chromosome Structural Dynamics and Gene Expression—A Chicken and Egg Dilemma?
Round 1
Reviewer 1 Report
The manuscript of Le Berre et al. focuses on an interesting subject related to the regulation of gene expression in bacteria. Some studies in recent years have been published indicating dynamic changes in chromosome structure due to bacterial adaptation to environmental conditions. Although there are still open questions about how this interplay happens in bacterial cells, this review paper is an exciting contribution to this field. It is interesting for a broader scientific community.
There are just some typing mistakes throughout the manuscript: ï should be replaced with i.
Reviewer 2 Report
The present article “Relationship between the chromosome structural dynamics and gene expression – a chicken and egg dilemma? Is a very interesting and compiled in a good way. Authors have tried to explain how the chromosome is dynamically reorganized under the changing environmental conditions and how this reorganization is related to gene expression. The article is well written and authors explained all the points in a well manner. I recommend accepting this article in present form.
