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Article

Epidemiological Evidence for Upper Respiratory Infections as a Potential Risk Factor for Meniere’s Disease: A Korean National Health Sample Cohort Study

by
Mi Jung Kwon
1,
Ho Suk Kang
2,
Joo-Hee Kim
3,
Ji Hee Kim
4,
Woo Jin Bang
5,
Dae Myoung Yoo
6,7,
Na-Eun Lee
6,7,
Kyeong Min Han
6,7,
Nan Young Kim
8,
Hyo Geun Choi
9,
Min-Jeong Kim
10 and
Eun Soo Kim
10,*
1
Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea
2
Division of Gastroenterology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea
3
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea
4
Department of Neurosurgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea
5
Department of Urology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea
6
Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Republic of Korea
7
Laboratory of Brain and Cognitive Sciences for Convergence Medicine, Hallym University College of Medicine, Anyang 14068, Republic of Korea
8
Hallym Institute of Translational Genomics and Bioinformatics, Hallym University Medical Center, Anyang 14068, Republic of Korea
9
Suseo Seoul E.N.T. Clinic, 10, Bamgogae-ro 1-gil, Gangnam-gu, Seoul 06349, Republic of Korea
10
Department of Radiology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea
*
Author to whom correspondence should be addressed.
Microorganisms 2024, 12(10), 2047; https://doi.org/10.3390/microorganisms12102047
Submission received: 13 September 2024 / Revised: 7 October 2024 / Accepted: 8 October 2024 / Published: 10 October 2024
(This article belongs to the Special Issue Advances in Human Infections and Public Health)
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Abstract

Meniere’s disease (MD) is a chronic inner ear disorder characterized by tinnitus, ear fullness, episodic vertigo, and fluctuating hearing loss, which significantly impacts quality of life and poses management challenges. Recent evidence suggests that upper respiratory infections (URIs) may contribute to MD’s onset. This study examines the potential link between URIs and MD using data from the Korean National Health Insurance Service-National Sample Cohort (2002–2019). We analyzed 19,721 individuals with MD and 78,884 matched controls, adjusting for demographic factors and comorbidities using propensity score matching. Our results showed that individuals with a URI within one year prior to the index date exhibited a 2.01-fold greater likelihood of developing MD (95% confidence interval [CI] = 1.91–2.11, p < 0.001), while those with URIs within two years demonstrated a 1.54-fold higher probability (95% CI = 1.50–1.59, p < 0.001). Furthermore, we found that even remote URIs occurring up to two years before the index date significantly increased the risk of developing MD, underscoring the need for long-term patient follow-up. Overall, our study suggests that individuals with a history of URI may have an elevated risk of developing MD over multiple time frames, regardless of demographic or health profiles.
Keywords: upper respiratory infections; Meniere’s disease; national sample cohort study; risk factor; big data analysis upper respiratory infections; Meniere’s disease; national sample cohort study; risk factor; big data analysis

Share and Cite

MDPI and ACS Style

Kwon, M.J.; Kang, H.S.; Kim, J.-H.; Kim, J.H.; Bang, W.J.; Yoo, D.M.; Lee, N.-E.; Han, K.M.; Kim, N.Y.; Choi, H.G.; et al. Epidemiological Evidence for Upper Respiratory Infections as a Potential Risk Factor for Meniere’s Disease: A Korean National Health Sample Cohort Study. Microorganisms 2024, 12, 2047. https://doi.org/10.3390/microorganisms12102047

AMA Style

Kwon MJ, Kang HS, Kim J-H, Kim JH, Bang WJ, Yoo DM, Lee N-E, Han KM, Kim NY, Choi HG, et al. Epidemiological Evidence for Upper Respiratory Infections as a Potential Risk Factor for Meniere’s Disease: A Korean National Health Sample Cohort Study. Microorganisms. 2024; 12(10):2047. https://doi.org/10.3390/microorganisms12102047

Chicago/Turabian Style

Kwon, Mi Jung, Ho Suk Kang, Joo-Hee Kim, Ji Hee Kim, Woo Jin Bang, Dae Myoung Yoo, Na-Eun Lee, Kyeong Min Han, Nan Young Kim, Hyo Geun Choi, and et al. 2024. "Epidemiological Evidence for Upper Respiratory Infections as a Potential Risk Factor for Meniere’s Disease: A Korean National Health Sample Cohort Study" Microorganisms 12, no. 10: 2047. https://doi.org/10.3390/microorganisms12102047

APA Style

Kwon, M. J., Kang, H. S., Kim, J.-H., Kim, J. H., Bang, W. J., Yoo, D. M., Lee, N.-E., Han, K. M., Kim, N. Y., Choi, H. G., Kim, M.-J., & Kim, E. S. (2024). Epidemiological Evidence for Upper Respiratory Infections as a Potential Risk Factor for Meniere’s Disease: A Korean National Health Sample Cohort Study. Microorganisms, 12(10), 2047. https://doi.org/10.3390/microorganisms12102047

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