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Microorganisms
Volume 12
Issue 2
10.3390/microorganisms12020373
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Article

Antiherpetic Activity of a Root Exudate from Solanum lycopersicum

by
Greta Bajetto
1,2,†,
Davide Arnodo
3,†,
Matteo Biolatti
1,
Linda Trifirò
1,
Camilla Albano
1,
Selina Pasquero
1,
Francesca Gugliesi
1,
Eva Campo
4,
Francesca Spyrakis
5,
Cristina Prandi
3,
Marco De Andrea
1,2,
Valentina Dell’Oste
1,*,
Ivan Visentin
4 and
Marco Blangetti
3,*
1
Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy
2
Center for Translational Research on Autoimmune and Allergic Disease (CAAD), 28100 Novara, Italy
3
Department of Chemistry, University of Turin, 10125 Turin, Italy
4
Department of Agricultural, Forestry, and Food Sciences, University of Turin, 10095 Turin, Italy
5
Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Microorganisms 2024, 12(2), 373; https://doi.org/10.3390/microorganisms12020373
Submission received: 29 December 2023 / Revised: 5 February 2024 / Accepted: 9 February 2024 / Published: 11 February 2024
(This article belongs to the Special Issue Innovative Antiviral Approaches and New Molecular Targets against Viral Infections)
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Abstract

The rise of drug resistance to antivirals poses a significant global concern for public health; therefore, there is a pressing need to identify novel compounds that can effectively counteract strains resistant to current antiviral treatments. In light of this, researchers have been exploring new approaches, including the investigation of natural compounds as alternative sources for developing potent antiviral therapies. Thus, this work aimed to evaluate the antiviral properties of the organic-soluble fraction of a root exudate derived from the tomato plant Solanum lycopersicum in the context of herpesvirus infections. Our findings demonstrated that a root exudate from Solanum lycopersicum exhibits remarkable efficacy against prominent members of the family Herpesviridae, specifically herpes simplex virus type 1 (HSV-1) (EC50 25.57 µg/mL, SI > 15.64) and human cytomegalovirus (HCMV) (EC50 9.17 µg/mL, SI 32.28) by inhibiting a molecular event during the herpesvirus replication phase. Moreover, the phytochemical fingerprint of the Solanum lycopersicum root exudate was characterized through mass spectrometry. Overall, these data have unveiled a novel natural product with antiherpetic activity, presenting a promising and valuable alternative to existing drugs.
Keywords: antivirals; herpesviruses; natural compounds; tomatoes; plant specialized metabolites; rhizosphere antivirals; herpesviruses; natural compounds; tomatoes; plant specialized metabolites; rhizosphere
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MDPI and ACS Style

Bajetto, G.; Arnodo, D.; Biolatti, M.; Trifirò, L.; Albano, C.; Pasquero, S.; Gugliesi, F.; Campo, E.; Spyrakis, F.; Prandi, C.; et al. Antiherpetic Activity of a Root Exudate from Solanum lycopersicum. Microorganisms 2024, 12, 373. https://doi.org/10.3390/microorganisms12020373

AMA Style

Bajetto G, Arnodo D, Biolatti M, Trifirò L, Albano C, Pasquero S, Gugliesi F, Campo E, Spyrakis F, Prandi C, et al. Antiherpetic Activity of a Root Exudate from Solanum lycopersicum. Microorganisms. 2024; 12(2):373. https://doi.org/10.3390/microorganisms12020373

Chicago/Turabian Style

Bajetto, Greta, Davide Arnodo, Matteo Biolatti, Linda Trifirò, Camilla Albano, Selina Pasquero, Francesca Gugliesi, Eva Campo, Francesca Spyrakis, Cristina Prandi, and et al. 2024. "Antiherpetic Activity of a Root Exudate from Solanum lycopersicum" Microorganisms 12, no. 2: 373. https://doi.org/10.3390/microorganisms12020373

APA Style

Bajetto, G., Arnodo, D., Biolatti, M., Trifirò, L., Albano, C., Pasquero, S., Gugliesi, F., Campo, E., Spyrakis, F., Prandi, C., De Andrea, M., Dell’Oste, V., Visentin, I., & Blangetti, M. (2024). Antiherpetic Activity of a Root Exudate from Solanum lycopersicum. Microorganisms, 12(2), 373. https://doi.org/10.3390/microorganisms12020373

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