Relationship between the Viral Load in Patients with Different COVID-19 Severities and SARS-CoV-2 Variants
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Identification of Positive Cases
- -
- Sequencing of the SARS-CoV-2 genome (CoViGen-Mex)
2.3. Quantification of SARS-CoV-2 Viral Load
- -
- Validation of the endogenous control
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Total | Group A (1–2 Days) | Group B (3–4 Days) | Group C (5–6 Days) | Group D (7–11 Days) | |
---|---|---|---|---|---|
Variants | |||||
Alpha | 386 | 118 | 90 | 76 | 102 |
Delta | 7463 | 2224 | 2137 | 1312 | 1790 |
Gamma | 642 | 213 | 163 | 101 | 165 |
Omicron | 8274 | 5094 | 2242 | 557 | 381 |
Others * | 115 | 21 | 44 | 22 | 28 |
Age group (years) | |||||
0–9 | 457 | 304 | 107 | 21 | 25 |
10–19 | 753 | 399 | 233 | 64 | 57 |
20–59 | 11,609 | 5768 | 3239 | 1258 | 1344 |
>60 | 4061 | 1199 | 1097 | 725 | 1040 |
Vaccines | |||||
No | 10,911 | 4770 | 2981 | 1382 | 1778 |
Yes (1 shot) | 1651 | 653 | 498 | 233 | 267 |
Yes (2 shots) | 4318 | 2247 | 1197 | 453 | 421 |
Sex | |||||
Female | 9204 | 4439 | 2594 | 1021 | 1150 |
Male | 7676 | 3231 | 2082 | 1047 | 1316 |
Patient type | |||||
Outpatient | 10,947 | 6128 | 3198 | 973 | 648 |
Hospitalized | 4000 | 1184 | 1003 | 668 | 1145 |
Death | 1931 | 358 | 475 | 427 | 671 |
Age Groups (Years) | Outpatient (%) | Hospitalized (%) | Death (%) | Total |
---|---|---|---|---|
0–9 | 296 (64.8) | 156 (34.1) | 5 (1.1) | 457 |
10–19 | 626 (83.1) | 123 (16.4) | 4 (0.5) | 753 |
20–59 | 9075 (78.2) | 1876 (16.1) | 658 (5.7) | 11,609 |
>60 | 950 (23.4) | 1845 (45.4) | 1266 (31.2) | 4061 |
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Santos Coy-Arechavaleta, A.; Alvarado-Yaah, J.E.; Uribe-Noguez, L.A.; Guerra-Castillo, F.X.; Santacruz-Tinoco, C.E.; Ramón-Gallegos, E.; Muñoz-Medina, J.E.; Fernandes-Matano, L. Relationship between the Viral Load in Patients with Different COVID-19 Severities and SARS-CoV-2 Variants. Microorganisms 2024, 12, 428. https://doi.org/10.3390/microorganisms12030428
Santos Coy-Arechavaleta A, Alvarado-Yaah JE, Uribe-Noguez LA, Guerra-Castillo FX, Santacruz-Tinoco CE, Ramón-Gallegos E, Muñoz-Medina JE, Fernandes-Matano L. Relationship between the Viral Load in Patients with Different COVID-19 Severities and SARS-CoV-2 Variants. Microorganisms. 2024; 12(3):428. https://doi.org/10.3390/microorganisms12030428
Chicago/Turabian StyleSantos Coy-Arechavaleta, Andrea, Julio Elias Alvarado-Yaah, Luis Antonio Uribe-Noguez, Francisco Xavier Guerra-Castillo, Clara Esperanza Santacruz-Tinoco, Eva Ramón-Gallegos, José Esteban Muñoz-Medina, and Larissa Fernandes-Matano. 2024. "Relationship between the Viral Load in Patients with Different COVID-19 Severities and SARS-CoV-2 Variants" Microorganisms 12, no. 3: 428. https://doi.org/10.3390/microorganisms12030428