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Volume 12
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10.3390/microorganisms12040677
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Article

A Noble Extract of Pseudomonas sp. M20A4R8 Efficiently Controlling the Influenza Virus-Induced Cell Death

by
Su-Bin Jung
1,†,
Grace Choi
2,†,
Hyo-Jin Kim
3,
Kyeong-Seo Moon
1,
Gun Lee
1,
Kyeong-Hak Na
1,
Yong Min Kwon
2,
Jimin Moon
4,
Mi Yeong Shin
5,
Jae-Yeong Yu
5,
Yeong-Bin Baek
3,
Jun-Gyu Park
6,* and
Sang-Ik Park
1,*
1
Department of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea
2
Department of Biological Application and Technology, National Marine Biodiversity Institute of Korea, Seocheon 33662, Republic of Korea
3
Department of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea
4
College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea
5
Department of Health Research, Jeollanam-do Institute of Health and Environment, Muan 58568, Republic of Korea
6
Department of Veterinary Zoonotic Diseases, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Microorganisms 2024, 12(4), 677; https://doi.org/10.3390/microorganisms12040677
Submission received: 6 March 2024 / Revised: 25 March 2024 / Accepted: 25 March 2024 / Published: 28 March 2024
(This article belongs to the Special Issue Research on Replication Mechanisms and Molecular Virology of Influenza Virus)
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Abstract

Epidemic diseases that arise from infectious RNA viruses, particularly influenza viruses, pose a constant threat to the global economy and public health. Viral evolution has undermined the efficacy of acquired immunity from vaccines and the antiviral effects of FDA-approved drugs. As such, there is an urgent need to develop new antiviral lead agents. Natural compounds, owing to their historical validation of application and safety, have become a promising solution. In this light, a novel marine bacterium, Pseudomonas sp. M20A4R8, has been found to exhibit significant antiviral activity [half maximal inhibitory concentration (IC50) = 1.3 µg/mL, selectivity index (SI) = 919.4] against influenza virus A/Puerto Rico/8/34, surpassing the activity of chloroquine. The antiviral response via M20A4R8 extract was induced during post-entry stages of the influenza virus, indicating suitability for post-application after the establishment of viral infection. Furthermore, post-treatment with M20A4R8 extract protected the host from virus-induced apoptosis, suggesting its potential use in acute respiratory disease complexes resulting from immune effectors’ overstimulation and autophagy-mediated self-apoptosis. The extract demonstrated an outstanding therapeutic index against influenza virus A/Wisconsin/15/2009 (IC50 = 8.1 µg/mL, SI = 146.2) and B/Florida/78/2015 Victoria lineage (IC50 = 3.5 µg/mL, SI = 343.8), indicating a broad anti-influenza virus activity with guaranteed safety and effectiveness. This study provides a new perspective on mechanisms for preventing a broad spectrum of viral infections through antiviral agents from novel and natural origins. Future studies on a single or combined compound from the extract hold promise, encouraging its use in preclinical challenge tests with various influenza virus strains.
Keywords: Pseudomonas; influenza virus; broad-spectrum therapeutics; marine bacterium; cell death Pseudomonas; influenza virus; broad-spectrum therapeutics; marine bacterium; cell death

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MDPI and ACS Style

Jung, S.-B.; Choi, G.; Kim, H.-J.; Moon, K.-S.; Lee, G.; Na, K.-H.; Kwon, Y.M.; Moon, J.; Shin, M.Y.; Yu, J.-Y.; et al. A Noble Extract of Pseudomonas sp. M20A4R8 Efficiently Controlling the Influenza Virus-Induced Cell Death. Microorganisms 2024, 12, 677. https://doi.org/10.3390/microorganisms12040677

AMA Style

Jung S-B, Choi G, Kim H-J, Moon K-S, Lee G, Na K-H, Kwon YM, Moon J, Shin MY, Yu J-Y, et al. A Noble Extract of Pseudomonas sp. M20A4R8 Efficiently Controlling the Influenza Virus-Induced Cell Death. Microorganisms. 2024; 12(4):677. https://doi.org/10.3390/microorganisms12040677

Chicago/Turabian Style

Jung, Su-Bin, Grace Choi, Hyo-Jin Kim, Kyeong-Seo Moon, Gun Lee, Kyeong-Hak Na, Yong Min Kwon, Jimin Moon, Mi Yeong Shin, Jae-Yeong Yu, and et al. 2024. "A Noble Extract of Pseudomonas sp. M20A4R8 Efficiently Controlling the Influenza Virus-Induced Cell Death" Microorganisms 12, no. 4: 677. https://doi.org/10.3390/microorganisms12040677

APA Style

Jung, S.-B., Choi, G., Kim, H.-J., Moon, K.-S., Lee, G., Na, K.-H., Kwon, Y. M., Moon, J., Shin, M. Y., Yu, J.-Y., Baek, Y.-B., Park, J.-G., & Park, S.-I. (2024). A Noble Extract of Pseudomonas sp. M20A4R8 Efficiently Controlling the Influenza Virus-Induced Cell Death. Microorganisms, 12(4), 677. https://doi.org/10.3390/microorganisms12040677

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