Next Article in Journal
Exploring the Role of a Putative Secondary Metabolite Biosynthesis Pathway in Mycobacterium abscessus Pathogenesis Using a Xenopus laevis Tadpole Model
Next Article in Special Issue
Research Progress in the Development of Vaccines against Mycoplasma gallisepticum and Mycoplasma synoviae
Previous Article in Journal
Synthetic Microbial Community Promotes Bacterial Communities Leading to Soil Multifunctionality in Desertified Land
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Microorganisms
Volume 12
Issue 6
10.3390/microorganisms12061118
microorganisms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Development and Evaluation of a New Inactivated Vaccine against Mycoplasma capricolum subsp. capricolum

by
Noha Semmate
1,2,*,
Zahra Bamouh
1,2,
Zouhair Elkarhat
2,3,
Soufiane Elmejdoub
2,
Mazen Saleh
4,
Ouafaa Fassi Fihri
1 and
Mehdi Elharrak
2
1
Department of Pathology and Veterinary Public Health, Agronomic and Veterinary Institute Hassan II, BP 6202, Rabat-Instituts, Rabat 10101, Morocco
2
Department of Research and Development, Multi-Chemical Industry Santé Animale, P.O. Box 278, Mohammedia 28810, Morocco
3
Institute of Thematic Research Specialized in Medical, Food and Environmental Biotechnology of Benslimane, Hassan II University of Casablanca (UH2C), Casablanca 20670, Morocco
4
School of Natural Sciences, Laurentian University, Sudbury, ON P3E 2C6, Canada; and the Northern Ontario School of Medicine University, Sudbury, ON P3E 5Z6, Canada
*
Author to whom correspondence should be addressed.
Microorganisms 2024, 12(6), 1118; https://doi.org/10.3390/microorganisms12061118
Submission received: 4 March 2024 / Revised: 19 March 2024 / Accepted: 27 March 2024 / Published: 31 May 2024
(This article belongs to the Special Issue Advances in Mycoplasma Research)
Browse Figures
Versions Notes

Abstract

Mycoplasma capricolum subsp. capricolum (Mcc) and Mycoplasma capricolum subsp. capripneumoniae (Mccp) are pathogens that affect large and small ruminants. Indeed, Mcc affects both sheep and goats, causing contagious agalactia (CA). Mccp affects only goats, causing contagious caprine pleuropneumonia (CCPP). CA and CCPP are mainly controlled using inactivated Mcc and Mccp vaccines. However, producing the vaccine with the Mccp strain is complex, fastidious, and costly due to the slow growth of the bacterium. In this study, we present new oil-adjuvanted and inactivated Mcc and Mccp vaccines for sheep and goats against CA and CCPP. The vaccines were evaluated for safety and efficacy using experimental infection. A serological response was observed one week after of the first vaccination of sheep and goats with Mcc and goats with Mccp. The vaccinated animals were subsequently challenged with the virulent Mcc MOR20 strain. The Mcc vaccine was demonstrated to provide robust protection when the animals were challenged with Mcc MOR20. Cross-protection against the Mcc MOR20 challenge was also obtained with the Mccp vaccine. This finding revealed, for the first time, the safety and efficacy of an inactivated Mcc vaccine against contagious agalactia and cross-protection between Mcc and Mccp strains.
Keywords: Mycoplasma capricolum subsp. capricolum; Mycoplasma capricolum subsp. capripneumoniae; vaccine; contagious agalactia; contagious caprine pleuropneumonia Mycoplasma capricolum subsp. capricolum; Mycoplasma capricolum subsp. capripneumoniae; vaccine; contagious agalactia; contagious caprine pleuropneumonia

Share and Cite

MDPI and ACS Style

Semmate, N.; Bamouh, Z.; Elkarhat, Z.; Elmejdoub, S.; Saleh, M.; Fihri, O.F.; Elharrak, M. The Development and Evaluation of a New Inactivated Vaccine against Mycoplasma capricolum subsp. capricolum. Microorganisms 2024, 12, 1118. https://doi.org/10.3390/microorganisms12061118

AMA Style

Semmate N, Bamouh Z, Elkarhat Z, Elmejdoub S, Saleh M, Fihri OF, Elharrak M. The Development and Evaluation of a New Inactivated Vaccine against Mycoplasma capricolum subsp. capricolum. Microorganisms. 2024; 12(6):1118. https://doi.org/10.3390/microorganisms12061118

Chicago/Turabian Style

Semmate, Noha, Zahra Bamouh, Zouhair Elkarhat, Soufiane Elmejdoub, Mazen Saleh, Ouafaa Fassi Fihri, and Mehdi Elharrak. 2024. "The Development and Evaluation of a New Inactivated Vaccine against Mycoplasma capricolum subsp. capricolum" Microorganisms 12, no. 6: 1118. https://doi.org/10.3390/microorganisms12061118

APA Style

Semmate, N., Bamouh, Z., Elkarhat, Z., Elmejdoub, S., Saleh, M., Fihri, O. F., & Elharrak, M. (2024). The Development and Evaluation of a New Inactivated Vaccine against Mycoplasma capricolum subsp. capricolum. Microorganisms, 12(6), 1118. https://doi.org/10.3390/microorganisms12061118

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop