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Microorganisms
Volume 13
Issue 5
10.3390/microorganisms13050992
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Investigating Skin Microbial Community in Malignant Melanoma Lesions

by
Michele Properzi
1,†,
Valentina Dimartino
1,†,
Daniele Pietrucci
2,*,
Carla Fontana
1,
Claudia Rotondo
1,
Luigi Lembo
3,
Francesco Ricci
4,
Francesca Scatozza
4,
Giovanni Di Lella
4,
Francesco Messina
1,
Giovanni Chillemi
1,5,
Barbara Bartolini
1,* and
Antonio Facchiano
4
1
National Institute for Infectious Diseases “Lazzaro Spallanzani”—IRCCS, 00149 Rome, Italy
2
Department for Innovation in Biological, Agro-Food and Forest Systems (DIBAF), University of Tuscia, 01100 Viterbo, Italy
3
Dermatologia Azienda Ospedaliera San Camillo Forlanini, 00152 Rome, Italy
4
Istituto Dermopatico dell’Immacolata, IDI-IRCCS, FLMM, 00167 Rome, Italy
5
Department of Experimental Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Microorganisms 2025, 13(5), 992; https://doi.org/10.3390/microorganisms13050992
Submission received: 5 March 2025 / Revised: 17 April 2025 / Accepted: 22 April 2025 / Published: 25 April 2025
(This article belongs to the Collection Feature Papers in Medical Microbiology)
Review Reports Versions Notes

Abstract

The skin microbiome is identified as one of the crucial factors in several pathological conditions, including its potential capacity in modulating cancer progression and response to treatment. A strong association of Bacilli and Betaproteobacteria classes and the Bacteroidetes phylum with melanoma is described in patients with cutaneous malignancies, while an imbalance of S. epidermidis and S. aureus is related to the progression of other skin cancers. In the present study, we characterized the microbial community in suspected lesions of 35 patients, classified, after histological analysis, as malignant melanoma lesions and benign non-melanoma lesions. Mirrored healthy skin were also included as negative control. No significant difference in alpha and beta diversity was observed when samples were categorized in four different groups (melanoma samples vs. contralateral healthy samples; melanoma samples vs. benign lesions; benign lesions vs. contralateral controls; melanoma controls vs. benign controls). The differential abundance analyses show that Corynebacterium urealyticum is more abundant in melanoma samples compared to their control, while Roseomonas gilardii is less abundant in melanoma. Staphylococcus massiliensis, Bacillus coagulans, Paracoccus yeei, Corynebacterium jeikeium, and Corynebacterium pyruviciproducens are present only in melanoma samples when compared with benign lesions.
Keywords: skin microbiota; biomarker; melanoma; benign skin lesion skin microbiota; biomarker; melanoma; benign skin lesion

Share and Cite

MDPI and ACS Style

Properzi, M.; Dimartino, V.; Pietrucci, D.; Fontana, C.; Rotondo, C.; Lembo, L.; Ricci, F.; Scatozza, F.; Di Lella, G.; Messina, F.; et al. Investigating Skin Microbial Community in Malignant Melanoma Lesions. Microorganisms 2025, 13, 992. https://doi.org/10.3390/microorganisms13050992

AMA Style

Properzi M, Dimartino V, Pietrucci D, Fontana C, Rotondo C, Lembo L, Ricci F, Scatozza F, Di Lella G, Messina F, et al. Investigating Skin Microbial Community in Malignant Melanoma Lesions. Microorganisms. 2025; 13(5):992. https://doi.org/10.3390/microorganisms13050992

Chicago/Turabian Style

Properzi, Michele, Valentina Dimartino, Daniele Pietrucci, Carla Fontana, Claudia Rotondo, Luigi Lembo, Francesco Ricci, Francesca Scatozza, Giovanni Di Lella, Francesco Messina, and et al. 2025. "Investigating Skin Microbial Community in Malignant Melanoma Lesions" Microorganisms 13, no. 5: 992. https://doi.org/10.3390/microorganisms13050992

APA Style

Properzi, M., Dimartino, V., Pietrucci, D., Fontana, C., Rotondo, C., Lembo, L., Ricci, F., Scatozza, F., Di Lella, G., Messina, F., Chillemi, G., Bartolini, B., & Facchiano, A. (2025). Investigating Skin Microbial Community in Malignant Melanoma Lesions. Microorganisms, 13(5), 992. https://doi.org/10.3390/microorganisms13050992

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